Browsing by Author "Can, Meltem Guner"
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Item Effects of Alprazolam and Melatonin Used for Premedication on Oxidative Stress, Glicocalyx Integrity and Neurocognitive Functions(AVES, 2018-01-01) Can, Meltem Guner; Ulugol, Halim; Gunes, Isin; Aksu, Ugur; Tosun, Melis; Karduz, Gulsum; Vardar, Kubra; Toraman, FevziObjective: The purpose of this investigation was to compare the effect of alprazolam and melatonin on oxidative stress, glicocalyx integrity and neurocognitive function in patients undergoing coronary artery bypass grafting (CABG). Methods: Overall, 42 patients undergoing CABG were retrospectively included in this study. Blood samples which preserved at -70 degrees C for a previous study were used for this study. The participants were divided into two groups. Patients in the Group A were administered alprazolam before the operation, whereas melatonin was used for premedication in the Group M. Blood samples were collected at three time points {[}T0: before anaesthesia induction, T1: admittance to intensive care unit (ICU), T2: 24 h after ICU admission], and oxidative stress parameters and glicocalyx integrity were evaluated. Furthermore, Mini-Mental State Examination was recorded to measure neurocognitive function. Results: The total thiol levels which were measured as an antioxidant parameter were significantly higher, and free Hb values were significantly lower in the Group M compared to the Group A (p<0.05). No significant differences were found in order to oxidative stress parameter levels, extubation time, length of hospital stay, durations of cross-clamp, cardiopulmonary bypass and operation and Mini-Mental State Examination results between the two groups (p>0.05). Conclusion: In light of positive effects on oxidatif stress parameters, melatonin may be considered as a good and safe premedication agent with its anxiolytic, antioxidant and minimal haemodynamic and respiratory effects.Item Prolonged Mechanical Ventilation Predictors in Patients Undergoing Liver Transplantation(BEZMIALEM VAKIF UNIV, 2019-01-01) Can, Meltem Guner; Ozer, AliObjective: Liver transplantation is the current treatment modality for end-stage liver disease. While there is increasing drive towards early extuhation in patients undergoing liver transplantation, prolonged meachanical ventilation (PMV) related to various factors can be observed. We tried to determine the risk factors associated with PMV. Methods: One hundred twenty five patients (age>18 years) of with the American Society of Anesthesiology (ASA) III-IV group undergoing liver transplantation were enrolled in this retrospective study. Patient charts, intraoperative and intensive care unit follow-up forms, and electronic medical recording system were used for data collection. Patients were categorized as having received (with) or not received (without) prolonged mechanical ventilation (>24 hours), and perioperative risk factors were attempted to determine. Results: No significant intergroup differences were found in demographic variables but ASA and model for end-stage liver disease (MELD) scores were significantly higher in the with- than in the without-PMV group. Total amount of suspension of erythrocytess suspension, fresh frosen plasm, and cell-saver blood used intraoperatively was higher in the with-PMV group but difference did not reach statistical significance. Patients with-PMV had significantly higher cryoprecipitate transfusion rates than did those without-PMV (p=0.007). While no significante intergroup differences were found in mortality and lenght of hospital stay