Browsing by Author "Canberk, Sule"

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A Different Perspective on Evaluating the Malignancy Rate of the Non-Diagnostic Category of the Bethesda System for Reporting Thyroid Cytopathology: A Single Institute Experience and Review of the Literature
(PUBLIC LIBRARY SCIENCE, 2016-01-01) Gunes, Pembegul; Canberk, Sule; Onenerk, Mine; Erkan, Murat; Gursan, Nilufer; Kilinc, Emine; Kilicoglu, Gamze Zeynep
Objective To determine the malignancy rate in the non-diagnostic (ND) category of the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) based on a different approach in relation to histopathology diagnoses. Study Design All ND fine needle aspirations (FNAs) that were performed under ultrasound guidance by an interventional radiologist with rapid on-site evaluation were included in the study. Slides were reevaluated to identify the cause of inadequacy as ``qualitative{''} or ``quantitative.{''} The malignancy rate of the ND category was assessed. Nodule/patient characteristics were compared between benign and malignant cases within the study cohort. Results The study cohort consisted of 192 ND aspirations. Overall there were 156 (81.3\%) women and 36 (18.7\%) men with a mean age of 50.6 years (range 24-82 years). The malignancy rate was 4.7\%. None of the nodules (size, consistency, and number) or patient characteristics (gender and age) were found to be predictive of malignancy. Conclusion The malignancy rate of the ND category was high when compared to BSRTC predictions, but at the low end of the reported malignancy rates in the literature. Our results revealed that cyto-histopathologic correlation and method of malignancy rate estimation could have an effect on a wide range of reported malignancy rates. Furthermore, patient/nodule dependent factors were not statistically found to be predictive of malignancy.
Avoidance of unnecessary fine-needle aspiration with the use of the Thyroid Imaging Reporting Data System classification and strain elastography based on The Bethesda System for Reporting Thyroid Cytopathology
(SPANDIDOS PUBL LTD, 2016-01-01) Erkan, Murat; Canberk, Sule; Kilicoglu, Gamze Z.; Onenerk, Mine; Uludokumaci, Atay; Gunes, Pembegul; Atasoy, Tugba
Thyroid fine-needle aspiration (FNA) biopsy has been widely accepted as an accurate and cost-effective tool in the management of thyroid nodules. To avoid unnecessary FNAs and provide appropriate management, patient evaluation should be based on a multidisciplinary approach. For this purpose, the Thyroid Imaging Reporting and Data System (TI-RADS) and strain elastography (SE) were proposed as tools for the risk assessment of malignancy in thyroid nodules. The aim of the present study was to analyze the utility of TI-RADS system and SE, along with FNA, and prospectively evaluate 369 consecutive patients referred for FNA of a thyroid nodule. TI-RADS was tested against The Bethesda System for Reporting Thyroid Cytopathology to determine whether there was an agreement between the two classification systems
Columnar cell variant of papillary thyroid carcinoma: Cytomorphological characteristics of 11 cases with histological correlation and literature review
(WILEY, 2017-01-01) Bongiovanni, Massimo; Mermod, Maxime; Canberk, Sule; Saglietti, Chiara; Sykiotis, Gerasimos P.; Pusztaszeri, Marc; Ragazzi, Moira; Mazzucchelli, Luca; Giovanella, Luca; Piana, Simonetta
BACKGROUNDThe columnar cell variant of papillary thyroid carcinoma (PTC-CCV) is a rare entity that demonstrates a more aggressive clinical course compared with the more common subtypes of PTC. On histology, it is defined by papillae or gland-like structures lined by columnar cells displaying prominent nuclear stratification. Because to the authors' knowledge no characteristic cytomorphological features have been identified to date and typical features of PTC often are absent on cytology, the diagnosis of PTC-CCV by fine-needle aspiration (FNA) is challenging. This prompted the authors to evaluate a series of PTC-CCV cases to identify features that could facilitate its diagnosis by FNA. METHODSA total of 11 surgical specimens of PTC-CCV with corresponding preoperative cytology were identified over a 21-year period. The cytological features of the aspirated specimens, consisting mostly of Papanicolaou and Diff-Quick smears, were evaluated retrospectively. RESULTSAll cases demonstrated the presence of papillary structures. The most important features observed in PTC-CCV FNA specimens were hypercellularity with nuclear superposition and a paucity of nuclear pseudoinclusions and grooves. CONCLUSIONSAlthough PTC-CCV may demonstrate features that overlap with those of the classic variant of PTC, hypercellular smears with papillary structures covered by cells with pseudostratified nuclei that show a paucity of nuclear pseudoinclusions and grooves should alert the cytopathologist to the possibility of this diagnosis. Cancer Cytopathol 2017
Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel
(WILEY, 2020-01-01) Johnson, Daniel N.; Onenerk, Mine; Krane, Jeffrey F.; Rossi, Esther Diana; Baloch, Zubair; Barkan, Guliz; Bongiovanni, Massimo; Callegari, Fabiano; Canberk, Sule; Dixon, Glen; Field, Andrew; Griffith, Christopher C.; Jhala, Nirag; Jiang, Sara; Kurtycz, Daniel; Layfield, Lester; Lin, Oscar; Maleki, Zahra; Perez-Machado, Miguel; Pusztaszeri, Marc; Vielh, Philippe; Wang, He; Zarka, Matthew A.; Faquin, William C.
Background Fine needle aspiration (FNA) is commonly used for the preoperative evaluation of salivary gland tumors. Tumor grade is a key factor influencing clinical management of salivary gland carcinomas (SGCs). To assess the ability to grade nonbasaloid SGCs in FNA specimens, an international panel of cytopathologists convened to review and score SGC cases. Methods The study cohort included 61 cases of primary SGC from the pathology archives of 3 tertiary medical centers. Cases from 2005 to 2016 were selected, scanned, and digitized. Nineteen cytopathologists blinded to the histologic diagnosis reviewed the digitized cytology slides and graded them as low, high, or indeterminate. The panelists' results were then compared to the tumor grades based on histopathologic examination of the corresponding resection specimens. Results All but 2 of the 19 (89.5\%) expert panelists review more than 20 salivary gland FNAs per year
Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis
(MDPI, 2022-01-01) Canberk, Sule; Barroca, Helena; Girao, Ines; Aydin, Ozlem; Uguz, Aysun; Erdogan, Kivilcim; Tastekin, Ebru; Bongiovanni, Massimo; Soares, Paula; Maximo, Valdemar; Schmitt, Fernando
Background: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer
Prevalence and diagnostic challenges of thyroid lymphoma: a multi-institutional study in non-Western countries
(JAPAN ENDOCRINE SOC, 2020-01-01) Hirokawa, Mitsuyoshi; Suzuki, Ayana; Hashimoto, Yuko; Satoh, Shinya; Canberk, Sule; Jhuang, Jie Yang; Jung, Chan Kwon; Tangnuntachai, Nichthida; Kovacevic, Bozidar; Zhu, Yun; Agarwal, Shipra; Kakudo, Kennichi
Research on the primary thyroid lymphoma (PTL) diagnosis is limited, with only a few large sample size studies, reported from Asian countries. The aim of the present study was to clarify the current prevalence and challenges in PTL diagnosis, and recommended ancillary studies for PTL in non-Western countries. PTL (n = 153) cases were retrieved from 10 institutions in non-Western countries and analyzed. Ultrasound examination (UE) and fine needle aspiration cytology (FNAC) were used as main preoperative diagnostic tools in all participating institutions. Flow cytometry (FCM) was performed in the 5 institutions (50\%). Lobectomy was the most common histological procedure to confirm the PTL diagnosis. All institutions routinely performed immuno-histochemical analysis. PTL was 0.54\% of malignant thyroid tumor cases, with mucosaassociated lymphoid tissue lymphoma (MALTL) and diffuse large B-cell lymphoma (DLBCL) being 54.9\% and 38.6\%, respectively. Kuma Hospital, where the frequency of MALTL was highest (83.7\%), routinely performed FCM using the materials obtained by FNAC. UE and FNAC sensitivities were 62.5\% and 57.8\%, respectively. In both UE and FNAC, sensitivity of MALTL was lower than of DLBCL. The study elucidated that the prevalence of PTL in non-Western countries was lower than previously reported. We propose that FCM should be more actively used to improve the preoperative diagnosis of MALTL. Our data predicted that the MALTL proportion will increase with improved diagnostic tools, while observation of PTL-suspected nodules without histological examination remains a viable option.
Progesterone receptor expression in fibromuscular dysplasia: A report of two unusual cases
(BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2019-01-01) Erkan, Murat; Canberk, Sule; Onenerk, Mine; Sayman, Elif; Gunes, Pembegul; Orhan, Gokcen
Fibromuscular dysplasia is rarely biopsied. Progesterone receptor expression in myofibroblastic cells is useful for the histopathological evaluation in difficult-to-diagnose cases. Herein, we report two unusual cases of fibromuscular dysplasia in which progesterone receptor expression was shown in vessel sections.