Browsing by Author "Coşar, C. Banu"

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    Generic Cyclosporine in the Treatment of Dry Eye Disease
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2022-01-01) Coşar, C. Banu; Kılavuzoğlu, A. Ebru; Çelebi, A. R. Cenk; Altıparmak, U. Emrah
    ABSTRACT Objectives: To investigate the efficacy and safety of a generic Cyclosporine 0.05% ophthalmic emulsion in chronic dry eye disease. Materails and Methods: Thirty patients with dry eye disease were included in this observational, prospective study. Patients were examined at baseline, at month -1,-3 and 6 of the study. The following were evaluated at each visit: CDVA (corrected distance visual acuity), corneal and conjunctival staining (Oxford) score, TBUT (tear break-up time), Schirmer-2 score, OSDI (Ocular Surface Disease Index) score, patient’s subjective rating scale of ocular discomfort, daily use of concomittant artificial tears, the researcher’s assessment of the global treatment response, and IOP (intraocular pressure). In addition, drug-related side effects were evaluated individually in each examination. When initiating dry eye treatment, cyclosporine was combined with topical loteprednol etabonate 0.5%. Results: There was a statistically significant improvement from baseline in corneal and conjunctival staining (decrease in mean Oxford score), TBUT, Schirmer-2 values, OSDI score, patient’s subjective rating score for ocular discomfort, and mean physician’s subjective assessment of global response to treatment at all follow-up visits (p<0.001). The mean daily use of artifical drops decreased statistically at all time points (<0.001). The most commonly reported adverse events were ocular burning (6.7%), followed by stinging (3.3%), conjunctival hyperemia (3.3%), foreign body sensation (3.3%), and visual disturbance (3.3%). Conclusion: Generic cyclosporine 0.05% ophthalmic emulsion with loteprednol etabonate 0.5% on initiation treatment has well-tolerability and improves subjective and objective measures of dry eye disease.
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    Laser in situ Keratomileusis Sonrası Pterjiyum
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2012-04-01) Coşar, C. Banu; Şener, A. Bozkurt
    ÖZET Pterjiyumun ilerlemesini önlemek amacıyla ultraviyole filtreli güneş gözlü ğü ve şapka kullanımı önerilmekte ancak ilerlemeyi kesin önleyici tıbbi veya cerrahi bir teknik bulunmamaktadır. Sunduğumuz olguda; laser in situ ke ratomileusis (LASIK) tedavisinden 7 yıl sonra gelişen pterjiyuma karşı flep kenarının bir bariyer görevi gördüğü ve pterjiyumun takip edildiği 2,5 yıl boyunca ilerlemediği izlenmiştir. Literatürde, LASIK sonrası gelişen pterji yumların seyrine dair veri mevcut değildir. Olgumuz, hem LASIK sonrası bu seyri dökümante etmek, hem de erken evrede korneaya yapılacak bir ke sinin pterjiyumu durdurucu etkisini sorgulamak açısından önem taşımak tadı