Browsing by Author "Dagyildizi, Lale"

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    Plasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus
    (AMER SOC MICROBIOLOGY, 2013-01-01) Babalik, Aylin; Ulus, Ismail Hakki; Bakirci, Nadi; Kuyucu, Tulin; Arpag, Huseyin; Dagyildizi, Lale; Capaner, Esen
    Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50\% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49\% or 100\% (P < 0.01), 66\% or 100\% (P < 0.05), 30\% or 50\% (P = 0.198), and 32\% or 21\% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients.