Browsing by Author "Demircioglu, Deniz"

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A Review on Cutaneous and Musculoskeletal Manifestations of CLOVES Syndrome
(DOVE MEDICAL PRESS LTD, 2022-01-01) Durmaz, Emel Ozturk; Demircioglu, Deniz; Dikmen, Pinar Yalinay; Alanay, Yasemin; Alanay, Ahmet; Demirkesen, Cuyan; Tokat, Fatma; Karaarslan, Ercan
CLOVES syndrome is a novel sporadic mosaic segmental overgrowth syndrome, currently categorized under the canopy of PROS (PIK3CA-related overgrowth spectrum) disorders. All PROS disorders harbor heterozygous postzygotic activating somatic mutations involving the PIK3CA gene. As an upstream regulator of the PI3K/AKT/mTOR signal transduction pathway, activating mutations of PIK3CA gene commence in uncontrolled growth of cutaneous, vascular (capillaries, veins, and lymphatics), adipose, neural, and musculoskeletal tissues. The excessive growth is segmental, patchy, asymmetric, and confined to body parts affected by the mutation. The term `CLOVES' is an acronym denoting congenital lipomatous overgrowth, vascular malformations, epidermal nevi and spinal (scoliosis) and/ or skeletal anomalies. The syndrome is characterized by an admixture of overgrown tissues, derived mainly from mesoderm and neuroectoderm. Among PROS disorders, CLOVES syndrome represents the extreme end of the spectrum with massive affection of almost the entire body. The syndrome might judiciously be treated with medications hampering with the PI3K/AKT/mTOR signal transduction pathway. This article aims at reviewing the cutaneous and musculoskeletal manifestations of CLOVES syndrome, as the paradigm for PROS disorders. CLOVES syndrome and other PROS disorders are still misdiagnosed, underdiagnosed, underreported, and undertreated by the dermatology community.
Did Dermatological Hospital Referrals and Practice of Dermatologists Change in Between Pre-covid and Covid Era? A Short-term Preliminary Evaluation
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2022-01-01) Kavak, Ayse; Erfan, Gamze; Aydingoz, IkbalEsen; Demir, Figen; Tukenmez-Demirci, Guelsen; Biyik-Ozkaya, Dilek; Demircioglu, Deniz; Yilmaz, Murat; Karapicak, Rabia; Sahin, Sedef
Objective: In this descriptive study, we aimed to evaluate features of dermatology referrals before and after Covid-19 pandemic. Materials and Methods: The patients referred to dermatology outpatient clinics of Acibadem Group Hospitals in Istanbul between the time intervals 2019 March 1st and August 31st (Group G1) and 2020 March 1st and August 31st (Group G2) were included in this study. G1 and G2 groups were compared in terms of age, gender, mean duration of complaints, the most common five anatomic regions and the most common five dermatoses. Results: Referral rate after Covid-19 pandemic was decreased by 40\%. Face (p=.0013, OR= 1.20, 95\% CI=1.07-1.34), scalp (p=.02, OR=1.23, 95\% CI=1.02-1.48) and hand (p=.04, 95\% OR=1.24, 95\% CI=1.00-1.54) were more common locations in 2020 (group G2) than in 2019 (G2 group). The most common five dermatoses were contact dermatitis (8.3\%), acne (8,1\%), wart (7,0\%), seborrheic dermatitis (5,7\%) and pyoderma (5,5\%) in G1 (2019), while the order was contact dermatitis (10,6\%), acne (7,5\%), seborrheic dermatitis (6,5\%), wart (6,4\%) and pyoderma (4,9\%) in G2 (2020). Contact dermatitis showed a significant increase after pandemic (p=.0017, OR=1.29, 95\% CI=1.10-1.51). In 2020, psoriasis and lichen planus showed a two-fold increases (P <.001, OR=2.00, 95\% CI=1.43-2.79 and p=.03, OR=1.92, 95\% CI=1.09-3.38, respectively), whereas frequency of molluscum contagiosum decreased significantly (p=.03, OR=0.49, 95\% CI=0.26-0.92). Conclusion: Although we found some remarkable results, relatively short-term period design with the limited patient population of this study needs to be verified in more comprehensive studies.
Secretan Syndrome: A Fluctuating Case of Factitious Lymphedema
(QUADRANT HEALTHCOM INC, 2021-01-01) Demircioglu, Deniz; Durmaz, Emel Ozturk; Sezer, Engin; Sahin, Sedef
Skin Biopsy Results of Geriatric Patients Over a 5-year Period and the Frequency of Skin Diseases Before and After COVID-19 Pandemic
(GALENOS PUBL HOUSE, 2022-01-01) Ozkaya, Dilek Biyik; Erfan, Gamze; Okuturlar, Yildiz; Tosuner, Zeynep; Demircioglu, Deniz; Timurkaynak, Ozgur
Objective: The number of older adults has increased throughout the world. Aging affects all the organs and creates psychological, physiologic and anatomic changes. One of the most important organs of the human body is the skin, which shows the effects of aging the most. This study aims to determine whether age, gender, and season of biopsy play a significant role in skin biopsy results. Additionally, the study investigates whether the frequency of skin diseases differs before and after the coronavirus disease-2019 (COVID-19) pandemic. Methods: We conducted a retrospective study on the histopathology results of patients over 65 years old between June 2016 and September 2021. The histopathology results were obtained from the Acibadem Pathology Department. Results: Of the 677 patients, 310 (45.8\%) were male and 367 (54.2\%) were female. The most common disease in all patients were benign cutaneous neoplasms (23\%), followed by eczematous disease (18.5\%) and epithelial cutaneous cancers (16.8\%). We divided the results into 12 groups: group 1: Urticaria, erythema and purpuras, group 2: Papulosquamous and eczematous diseases, group 3: Infectious diseases, group 4: Rheumatologic diseases and alopecia, group 5: Benign cutaneous neoplasms, group 6: Precancerous lesions, group 7: Basal cell carcinoma, squamous cell carcinoma, group 8: Cutaneous metastasis and other skin cancers, group 9: Pigmentation disorders, group 10: Pschycology related dermatological disorders, group 11: Granulomatous dermatitis, group 12: Bullous dermatitis. Before the COVID-19 pandemic, the most prevalent results were group 2 (21.3\%), followed by group 5 (20.4\%) and group 7 (16.7\%) whereas, after the COVID-19 pandemic, the most frequent results were group 5 (28.4\%) followed by group 7 (17.1\%), and group 6 (14.9\%). In terms of seasons, the most common diseases were group 5 (24.1\%) in winter, group 2 (21.6\%) in spring, group 5 (30.0\%) in summer, and group 2 (18.9\%) in autumn. Before the COVID-19 pandemic, the most common result was group 2 (21.3\%), followed by group 5 (20.4\%) and group 7 (16.7\%), and during the COVID-19 pandemic, the most common result was group 5 (28.4\%), followed by group 7 (17.1\%), group 6 (14.9\%). Conclusion: Many skin diseases affect the geriatric population. Geriatric patients face challenges such as multiple drug use, comorbidities, mobility problems and cognitive disorders. In our study, the most common diseases in all patients were benign cutaneous neoplasms (23\%), followed by eczematous diseases (18.5\%), and epithelial cutaneous cancers (16.8\%). Knowing about the frequency of skin diseases is critical for the early detection of precancerous and cancerous lesions.