Browsing by Author "Demirkesen, Cuyan"

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A Rare Confusing Nevus Variant: Meyerson Nevus
(AVES, 2018-01-01) Yildiz, Pelin; Kucuk, Ozlem Su; Tosuner, Zeynep; Arici, Belfin Nur; Dizman, Didem; Deveci, Ugur; Demirkesen, Cuyan
Meyerson nevus is a rare benign entity described by Meyerson et al in 1971 as a melanocytic nevus surrounded by inflammatory, eczematous eruption that resolves spontaneously or by topical steriod therapy (fluticasone propionate, Abdi Ibrahim Ilac San. ve Tic. A.S., Istanbul), but the nevus persists. This entity is not well known and there is limited information in the literature. Since the lesion may develop suspicion for malignancy, it is important to keep this entity in mind. In this article we present three Meyerson nevi, two of which belong to one patient.
A Retrospective Multicenter Evaluation of Cutaneous Melanomas in Turkey
(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014-01-01) Gamsizkan, Mehmet; Yilmaz, Ismail; Buyukbabani, Nesimi; Demirkesen, Cuyan; Demiriz, Murat; Cetin, Emel Dikicioglu; Ince, Umit; Akalin, Taner; Demirkan, Nese Calli; Lebe, Banu; Erdem, Ozlem; Gokoz, Ozay; Sakiz, Damlanur; Demireli, Peyker Temiz; Astarci, Hesna Muzeyyen; Adim, Saduman Balaban; Zemheri, Itir Ebru; Acikalin, Arbil; Yaman, Banu; Aydin, Ovgu; Bassorgun, Cumhur Ibrahim
Background: We defined melanoma distribution in a large series of Turkish patients and evaluated the prognostic parameters of melanomas. Materials and Methods: A total of 1574 patients' data was retrospectively collected at 18 centers in Turkey. Demographic characteristics were questioned and noted. Prognostic parametres were evaluated based on sentinel lymph node involvement. Results: Mean age was 56.7 (4-99) years. While 844 (53.6\%) cases were male, 730 (46.4\%) cases were female. One thousand four hundred forty-seven (92\%) cases were invasive melanoma and 127 (8\%) cases were in-situ melanoma. The most common histopathological form was the superficial spreading melanoma (SSM) which was found in 549 patients (37.9\%). It was followed by nodular melanoma in 379 (26.2\%), acral lentiginous melanoma (ALM) in 191 (13.2\%) and lentigo maligna melanoma in 132 (9.1\%), respectively. On univariate analysis, lymphovascular invasion (p<0.001), tumor thickness (p<0.001), histopathological subtype (p<0.001), Clark level (p=0.001), ulceration (p<0.001), >= 6/mm(2) mitosis (p=0.005), satellite formation (p=0.001) and gender (p=0.03) were found to be associated with sentinel lymph node positivity. Regression was associated with sentinel lymph node negativity (p=0.017). According to multivariate analysis, lymphovascular invasion and tumor thickness were significant independent predictive factors of SLN positivity. Patient age, tumor localization, precursor lesions, lymphocytic infiltration and neurotropism were not related with sentinel lymph node involvement. Conclusions: In this retrospective analysis, it was found that the prevalence of SSM is at a lower rate while the prevalence of ALM is at a higher rate when compared to western countries. According to Breslow index
A Review on Cutaneous and Musculoskeletal Manifestations of CLOVES Syndrome
(DOVE MEDICAL PRESS LTD, 2022-01-01) Durmaz, Emel Ozturk; Demircioglu, Deniz; Dikmen, Pinar Yalinay; Alanay, Yasemin; Alanay, Ahmet; Demirkesen, Cuyan; Tokat, Fatma; Karaarslan, Ercan
CLOVES syndrome is a novel sporadic mosaic segmental overgrowth syndrome, currently categorized under the canopy of PROS (PIK3CA-related overgrowth spectrum) disorders. All PROS disorders harbor heterozygous postzygotic activating somatic mutations involving the PIK3CA gene. As an upstream regulator of the PI3K/AKT/mTOR signal transduction pathway, activating mutations of PIK3CA gene commence in uncontrolled growth of cutaneous, vascular (capillaries, veins, and lymphatics), adipose, neural, and musculoskeletal tissues. The excessive growth is segmental, patchy, asymmetric, and confined to body parts affected by the mutation. The term `CLOVES' is an acronym denoting congenital lipomatous overgrowth, vascular malformations, epidermal nevi and spinal (scoliosis) and/ or skeletal anomalies. The syndrome is characterized by an admixture of overgrown tissues, derived mainly from mesoderm and neuroectoderm. Among PROS disorders, CLOVES syndrome represents the extreme end of the spectrum with massive affection of almost the entire body. The syndrome might judiciously be treated with medications hampering with the PI3K/AKT/mTOR signal transduction pathway. This article aims at reviewing the cutaneous and musculoskeletal manifestations of CLOVES syndrome, as the paradigm for PROS disorders. CLOVES syndrome and other PROS disorders are still misdiagnosed, underdiagnosed, underreported, and undertreated by the dermatology community.
Adult orbital xanthogranulomatous disease: A case report and brief discussion of the terminology
(MEDKNOW PUBLICATIONS \& MEDIA PVT LTD, 2016-01-01) Tekin, Burak; Simsek, Ilke Bahceci; Akpinai, Reha; Demirkesen, Cuyan
Cutis laxa-like pseudoxanthoma elasticum with osteoma cutis
(MEDKNOW PUBLICATIONS \& MEDIA PVT LTD, 2017-01-01) Leblebici, Cem; Falay, Tugba; Zirtiloglu, Sibel; Demirkesen, Cuyan
Is this psoriasis or something else?
(SCIENTIFIC SCHOLAR LLC, 2022-01-01) Duman, Deniz Demircioglu; Durmaz, Emel Ozturk; Demirkesen, Cuyan; Sahin, Sedef
A 38-year-old man presented with a history of intractable itchy eruption on the buttocks, present for the last 6 years. The lesions had gradually spread over time and did not respond to several topical steroids. Dermatological examination revealed a butterfly-shaped erythematous verrucous plaque, involving both buttocks and gluteal cleft {[}Figure 1], and peripheral guttate red-brown discrete papules {[}Figure 2]. Histologic examination of a punch biopsy specimen displayed orthokeratosis, follicular plugging, numerous oblique columns of parakeratosis called cornoid lamellae, extending at about 45 degrees from the surface of
Lichen planopilaris restricted to the vitiliginous skin on the leg
(WILEY, 2021-01-01) Erbas, Gizem; Demirkesen, Cuyan; Alper, Sibel; Memet, Bachar; Vural, Secil
New onset of pemphigus foliaceus following BNT162b2 vaccine
(WILEY, 2022-01-01) Yildirici, Sebnem; Yayli, Savas; Demirkesen, Cuyan; Vural, Secil
Red forehead dot(s) and migraine
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020-01-01) Durmaz, Emel Ozturk; Demirkesen, Cuyan
Transient Acantholytic Dermatosis: New Dermatoscopic Features
(WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2021-01-01) Mansur, Ayse T.; Demirkesen, Cuyan
Two Clinically Unusual Cases of Folliculotropic Mycosis Fungoides: One with and the Other without Syringotropism
(KOREAN DERMATOLOGICAL ASSOC, 2014-01-01) Bakar, Ozgur; Seckin, Dilek; Demirkesen, Cuyan; Baykal, Can; Buyukbabani, Nesimi
Mycosis fungoides is the most common form of cutaneous T-cell lymphoma, and it rarely exhibits predilection for hair follicle and eccrine gland infiltration. Here, we present 2 similar cases that display folliculotropism with varying amounts of follicular mucinosis, with and without syringotropism. The features observed in both cases were cystic, comedo-like, acneiform lesions