Browsing by Author "Deniz, Sinan"

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    Trans-Arterial Chemoembolization with 50 mu m Degradable Starch Microspheres Versus 300-500 mu m Drug Eluting Beads in Hepatocellular Carcinoma: A Comparative Analysis of Initial Treatment Outcomes
    (UBIQUITY PRESS LTD, 2022-01-01) Yildiz, Isil; Deniz, Sinan; Ozer, Ali; Caliskan, Kosti
    Background and Aims: Trans-arterial chemoembolization (TACE) has become a widely accepted treatment in unresectable hepatocellular carcinoma (HCC). We aimed at comparing the efficacy of Degradable Starch Microspheres (DSMs)-TACE with 50 +/- 7 mu m versus 300-500 mu m Drug Eluting Beads (DEB)-TACE in terms of initial clinical and radiological treatment response parameters. Material and Methods: A total of 54 patients with unresectable HCC who underwent DEB-TACE (n = 25) or DSMs-TACE (n = 29) were included in this retrospective study. Baseline demographic and clinical characteristics, duration of follow-up, local recurrence and survival status, as well as treatment outcome including treatment response via modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria, viable and total tumor diameter and serum alpha-fetoprotein (AFP) levels were analyzed in both study groups. Results: No significant difference was noted between the two groups in terms of local recurrence (31.6 vs. 16.7\%) or mortality (73.9 vs. 85.7\%) rates after 36-month and 12-month follow-up, respectively. DSMs-TACE vs. DEB-TACE was associated with significantly higher complete response rate (27.6 vs. 0.0\%, p = 0.011) and significant decrease in serum AFP levels (p = 0.013). Conclusion: Both DSMs-TACE with 50 +/- 7 mu m microspheres and 300-500 mu m DEB-TACE are effective for local control of unresectable HCC. Our findings revealed superiority of DSMs-TACE over DEB-TACEnin terms of initial clinical and radiological tumor response
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    Ultrasonography and Fluoroscopy Guided Percutaneous Placement of Hickman Catheters in Children
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2020-01-01) Çevik, Muazez; Deniz, Sinan; Çalışkan, Can
    ABSTRACT Purpose: Hickman catheters (HCs) are commonly used in children who need bone marrow transplantation. Although several methods of implantation have been described, the aim of the present study was to evaluate the results of ultrasonography-and fluoroscopy-guided percutaneous insertion of HCs into a central vein in children. Materials and Methods: Data from patients who were hospitalized for ultrasonography-and fluoroscopy-guided percutaneous placement of HCs from August 2014 to January 2017 were retrospectively evaluated. The data were evaluated with respect to patient characteristics, complications, HC features, and outcomes. Results: Three hundred and six times HC positioned in 206 patients were evaluated. One hundred and twenty-six patients were male, and the remaining 80 were female. The age of the patients ranged from 2 months to 19 (range, 7.31±4.85) years. HC implantation was technically successful in all patients. The right jugular vein was the preferred access vein in 87.4% of HCs. The length of time between HC placement and removal was 147±108.9 days (range, 7–795 days). Three (0.01%) of the recorded complications were classified as early postoperative. Two of those three patients developed bleeding, and one had cardiac tamponade. No mortality was related to HC insertion during the perioperative or postoperative period. Conclusion: Ultrasonography-and fluoroscopy-guided percutaneous HC insertion in a central vein is safe and applicable to all children regardless of size, age, or diagnosis.