Browsing by Author "Geyik, Oyku Gonul"

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    Adaptive phenotypic modulations lead to therapy resistance in chronic myeloid leukemia cells
    (PUBLIC LIBRARY SCIENCE, 2020-01-01) Baykal-Kose, Seda; Acikgoz, Eda; Yavuz, Ahmet Sinan; Geyik, Oyku Gonul; Ate, Halil; Sezerman, Osman Ugur; Ozsan, Guner Hayri; Yuce, Zeynep
    Tyrosine kinase inhibitor (TKI) resistance is a major problem in chronic myeloid leukemia (CML). We generated a TKI-resistant K562 sub-population, K562-IR, under selective imatinib-mesylate pressure. K562-IR cells are CD34(-)/CD38(-), BCR-Abl-independent, proliferate slowly, highly adherent and form intact tumor spheroids. Loss of CD45 and other hematopoietic markers reveal these cells have diverged from their hematopoietic origin. CD34 negativity, high expression of E-cadherin and CD44