Browsing by Author "Gunduz, Abdulkadir"

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    A Comparison of the Effects of Grayanotoxin-Containing Honey (Mad Honey), Normal Honey, and Propolis on Fracture Healing
    (KARGER, 2018-01-01) Sahin, Aynur; Turkmen, Suha; Guzel, Nizamettin; Mentese, Ahmet; Turedi, Suleyman; Karahan, Suleyman Caner; Yulug, Esin; Demir, Selim; Aynaci, Osman; Deger, Orhan; Gunduz, Abdulkadir
    Objectives: Delayed healing and non-union of fractures have a significant effect upon patient morbidity. Studies have therefore largely concentrated on accelerating fracture healing. This study was intended to compare the effect of ``mad honey{''} and propolis on fracture healing using radiological and histopathological analysis. Subjects and Methods: Femur fracture was surgically performed on 48 rats, followed by fixation. Animals were then divided into 8 groups: 2 control groups (15-and 30-day) and 6 treatment groups (15-and 30-day normal honey, 15-and 30-day ``mad honey,{''} and 15-and 30-day propolis). Rats were sacrificed at the end of these periods, and radiological and histological examinations were performed. Results: Radiological healing in the propolis group after 15-day therapy was statistically better than in the control (p = 0.004) and normal honey (p = 0.006) groups. After 30-day therapy, healing in the propolis group (p = 0.005) and grayanotoxin-containing ``mad honey{''} group (p = 0.007) were significantly better than in the control group. Histologically, there was a statistically significant difference between the 15-day propolis group and the other groups (control, honey, mad honey: p = 0.003, p = 0.003, and p = 0.002, respectively). We also found a statistically significant difference when the 30-day propolis group (p = 0.005) and `` mad honey{''} group (p = 0.007) were compared to the control group. Conclusions: This study shows that grayanotoxin-containing `` mad honey{''} and propolis can accelerate fracture healing. (C) 2018 The Author(s) Published by S. Karger AG, Basel.
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    The Diagnostic Value of Protein Carbonyl Levels in Acute Carbon Monoxide Intoxication
    (DUZCE UNIV, 2017-01-01) Gunaydin, Mucahit; Turkmen, Suha; Karaca, Yunus; Tatli, Ozgur; Yildirim, Furkan; Altinkaynak, Buket Akcan; Gunduz, Abdulkadir
    Objective: Carbon monoxide (CO) is the main cause of intoxication-related mortality and morbidity in developed countries. It is responsible for more than half of fatal intoxications in many countries. The purpose of this study was to determine the diagnostic value of protein carbonyl (PC), a good marker of oxidative stress, in association with oxidative stress resulting from hypoxia emerging in patients with acute CO intoxication. Methods: Thirty-four patients diagnosed with acute CO intoxication at the Emergency Department and 38 healthy volunteers were included in the study. Patients' PC levels at time of admission and after treatment were compared with those of a control group. Results: No statistically significant difference was observed among PC levels at time of admission in the patient and control groups (p = 0.305, patient group 0.025 +/- 0.01, control group 0.026 +/- 0.01). A significant decrease was determined in post-treatment PC levels in the patient group compared to those at time of admission (p = 0.006, admission 0.025 +/- 0.01, post-treatment 0.017 +/- 0.008). No significant correlation was determined between patients' carboxyhemoglobin (CO-Hb) levels and PC levels at time of admission (Correlation coefficient = -0.006, p= 0.971). Conclusions: We think that PC is not suitable for use as a biomarker in the acute period in patients with CO intoxication.