Browsing by Author "Gurcan, Fatih"

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    Secondary cancer risk after whole-breast radiation therapy: field-in-field versus intensity modulated radiation therapy versus volumetric modulated arc therapy
    (BRITISH INST RADIOLOGY, 2019-01-01) Haciislamoglu, Emel; Cinar, Yunus; Gurcan, Fatih; Canyilmaz, Emine; Gungor, Gorkem; Yoney, Adnan
    Objective: In this study, we used the concept of organ-equivalent dose (OED) to evaluate the excess absolute risk (EAR) for secondary cancer in various organs after radiation treatment for breast cancer. Methods: Using CT data set of 12 patients, we generated three different whole-breast radiation treatment plans using 50 Gy in 2Gy fractions: three-dimensional conformal radiotherapy with a field-in-field (FinF) technique, intensity modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT). The OEDs were calculated from differential dose-volume histograms on the basis of the ``linear-exponential,{''} ``plateau,{''} and `'full mechanistic{''} dose-response models. Secondary cancer risks of the contralateral breast (CB), contralateral lung (CL), and ipsilateral lung (IL) were estimated and compared. Results: The lowest EARs for the CB, CL, and IL were achieved with FinF, which reduced the EARs by 77\%, 88\%. and 56\% relative to those with IMRT, and by 77\%, 84\%, and 58\% relative to those with VMAT, respectively. The secondary cancer risk for FinF was significantly lower than those of IMRT and VMAT. OED-based secondary cancer risks for CB and IL were similar when IMRT and VMAT were used, but the risk for CL was statistically lower when VMAT was used. Conclusion: The overall estimation of EAR indicated that the radiation-induced cancer risk of breast radiation therapy was lower with FinF than with IMRT and VMAT. Therefore, when secondary cancer risk is a major concern, FinF is considered to be the preferred treatment option in irradiation of whole-breast. Advances in knowledge: Secondary malignancy estimation after breast radiotherapy is becoming an important subject for comparative treatment planning.When secondary cancer risk a major concern, FinF technique is considered the preferred treatment option in whole breast patients.