Browsing by Author "Karagun, Barbaros Sahin"

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    Clinical and radiological features of COVID-19 infection in pediatric hematology-oncology and transplant patients
    (CUKUROVA UNIV, FAC MEDICINE, 2022-01-01) Aygunes, Utku; Karagun, Barbaros Sahin; Sasmaz, Hatice Ilgen; Akbas, Tugana; Antmen, Bulent
    Purpose: The goal of this study is to explain the characteristics of COVID-19 in this demographic, as well as the impact it had on pediatric cancer care during the pandemic. Materials and Methods: Fifteen COVID-19 patients diagnosed were studied retrospectively. Clinical, laboratory and radiological data were collected in relation to 15 patients under the age of 18 who tested positive for SarsCoV-2. Results: Of the 12117 pediatric hemato-oncological patients tested for COVID-19, 1125 patients showed symptoms, and 14 tested positive. The majority of cases suffered minor illnesses. A total of ten children required inpatient care, five needed oxygen support, and four required mechanical ventilation and later died. It was noted that the duration of real-time polymerase chain reaction (RT-PCR) positivity was prolonged in patients receiving intensive chemotherapy and/or immunosuppressive therapy. Patients' chemotherapy was delayed in all 15 (100\%) Sars-CoV-2-positive patients. Although changes visible on chest computed tomography (CT) imaging of children were mainly milder than in adults, radiological findings were more severe in patients who received relatively intensive cancer treatment. Conclusion: Children who have been treated for cancer or who have undergone a hematopoietic stem cell transplantation (HSCT) may be at greater risk of severe COVID-19 and should be under constant observation.
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    Different Kinetics and Risk Factors for Isolated Extramedullary Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Leukemia
    (ELSEVIER SCIENCE INC, 2021-01-01) Hazar, Volkan; Ozturk, Gulyuz; Yalcin, Koray; Uygun, Vedat; Aksoylar, Serap; Kupesiz, A.; Bozkaya, Ikbal Ok; Karagun, Barbaros Sahin; Bozkurt, Ceyhun; Ileri, Talia; Atay, Didem; Kocak, Ulker; Karasu, Gulsun Tezcan; Yesilipek, Akif; Gokce, Muge; Kansoy, Savas; Kintrup, Gulen Tuysuz; Karakukcu, Musa; Okur, Fatma Visal; Ertem, Mehmet; Kaya, Zuhre; Gursel, Orhan; Yaman, Yontem; Ozbek, Namik; Antmen, Bulent; Tufekci, Ozlem; Albayrak, Canan; Aksoy, Basak Adakli; Sezgin, Gulay; Albayrak, Davut; Evim, Melike Sezgin; Zengin, Emine; Pekpak, Esra; Transpl, Turkish Pediat Bone Marrow
    Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most frequent cause of post-transplantation mortality. Isolated extramedullary (EM) relapse (iEMR) after HSCT is relatively rare and not well characterized, particularly in pediatric patients. We retrospectively analyzed 1527 consecutive pediatric patients with acute leukemia after allo-HSCT to study the incidence, risk factors, and outcome of iEMR compared with systemic relapse. The 5 -year cumulative incidence of systemic relapse (either bone marrow {[}BM] only or BM combined with EMR) was 24.8\%, and that of iEMR was 5.5\%. The onset of relapse after allo-HSCT was significantly longer in EM sites than in BM sites (7.19 and 5.58 months, respectively
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    Rebound thymic hyperplasia after bone marrow transplantation in children with haemato-oncological diseases
    (TERMEDIA PUBLISHING HOUSE LTD, 2018-01-01) Arpaci, Taner; Karagun, Barbaros Sahin
    Aim of the study: To evaluate prevalence of rebound thymic hyperplasia (RTH) after bone marrow transplantation (BMT) in paediatric patients with haemato-oncological diseases. Material and methods: Between February 2013 and December 2017, BMT was performed in 189 paediatric patients with haemato-oncological diseases in our institution. Fifty-six patients who underwent at least two chest computed tomography (CT) exams performed before and after BMT were included in the study. Maximum transverse and anterior-posterior (AP) diameters and CT attenuation of the thymus were measured on axial images. Thymic enlargement was considered when both transverse and AP diameters increased. RTH was defined as the presence of thymic enlargement on CT after BMT relative to the CT taken before. Results: Twenty of 56 patients (36\%) demonstrated RTH (12 boys, 8 girls