Browsing by Author "Kocyigit, Yucel"

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    Can follicular Emmprin and BMP 4 levels predict ICSI outcome?
    (SPRINGER/PLENUM PUBLISHERS, 2019-01-01) Takmaz, Ozguc; Yozgatli, Dilara; Ozaltin, Selin; Ozbasli, Esra; Kocyigit, Yucel; Kuran, Sibel Bulgurcuoglu; Bulut, Huri; Gungor, Mete; Buyru, Faruk; Bastu, Ercan
    PurposeTo evaluate the relationship of clinical pregnancy rates with bone morphogenetic proteins 2-4-7 (BMP 2, 4, 7), growth differentiation factor 9 (GDF 9), and Emmprin levels in follicular fluid of intracytoplasmic sperm injection patients.MethodsFollicular fluid of 77 patients who underwent ICSI procedure was collected during the oocyte retrieval procedure. And follicular fluid levels of BMP 2, BMP 4, BMP 7, GDF 9, and Emmprin (Basigin) were measured and compared for clinical pregnancy rates.ResultsFollicular levels of BMP 4 was significantly higher whereas Emmprin levels were lower in patients who had achieved clinically diagnosed pregnancy compared with those who did not achieve clinical pregnancy after ICSI procedure (P=0.007 and P=0.035, respectively). BMP 2, BMP 7, and GDF 9 levels were comparable for both groups.ConclusionClinical pregnancy rates after ICSI may be associated with follicular fluid levels of Emmprin and BMP 4. Follicular levels of Emmprin and BMP 4 can be used as a marker (as markers for predicting ICSI outcomes) for a better ICSI outcome.
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    IS AMNIOTIC FLUID ANALYSIS DURING THE SECOND TRIMESTER A PREDICTOR FOR THE DETECTION OF PRETERM LABOR?
    (ISTANBUL UNIV, FAC MEDICINE, PUBL OFF, 2020-01-01) Kocyigit, Yucel; Celik, Hale Goksever; Simsek, Mehmet
    Objective: Premature activation of the hypothalamic-pituitary-adrenal axis due to stress can initiate preterm labor. Many mechanisms have been proposed to explain etiopathogenesis. The most important one is clinical and subclinical chorioamnionitis. We aimed to assess the possibility of early detection and prevention of preterm labor based on second trimester amniotic fluid analysis. Material and Method: One hundred and twenty-five pregnant women with singleton pregnancies who underwent amniocentesis were included. The first 2 cm(3) of the amniotic fluid obtained during the amniocentesis was used for glucose, interleukin-1, interleukin-6, high sensitivity C-reactive protein, electrolytes, progesterone/estrogen analysis, and cell counts. Results: Sixteen women (13.8\%) went into labor prior to 37 weeks of gestation. The mean age of the study population was 33.2 +/- 6.25 years. Ages were similar between the preterm and term groups (36.06 +/- 3.91 vs 32.77 +/- 6.43). Furthermore, the analysis of all parameters in the amniotic fluid did not show any statistical significant difference between the groups. Conclusion: The possible effects of subclinical infection and steroid hormonal changes that are implied in the etiology of preterm labor were investigated in our study, and no evidence was found to support that these factors played a role in the etiology of preterm labor.