Browsing by Author "Konukoglu, Dildar"

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Importance of oxidative stress in the evaluation of acute pulmonary embolism severity
(BMC, 2022-01-01) Sagcan, Gulseren; Konukoglu, Dildar; Uzun, Hafize; Arseven, Orhan; Okumus, Gulfer; Cuhadaroglu, Caglar
Background Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Our study was aimed to investigate whether oxidative stress markers can be used as clinical markers in the evaluation of acute PE (APE) severity. Methods 47 patients with objectively documented diagnosis of APE were recorded. Of these patients, 14 had low-risk PE, 16 had moderate-risk PE, and 17 had high-risk PE. 21 healthy subjects were also enrolled in this study. Ischemia-modified albumin (IMA), prooxidants-antioxidants balance (PAB), advanced protein oxidation products (AOPPs), and ferric reducing antioxidant power (FRAP) were measured as oxidative stress parameters to evaluate the role of oxidative stress. Results In the low-risk and moderate-risk APE groups, AOPPs and PAB levels were significantly higher and FRAP levels were significantly lower than those in the control group. AOPPs and IMA levels in the patients with high-risk PE were significantly higher than those in both the low-risk and moderate-risk APE patients. There was a significant correlation between levels of AOPPs and the levels of both IMA (r: 0.462, p < 0.001) and PAB (r:0.378, p < 0.005). Serum FRAP levels were negatively correlated with PAB (r:- 0.683, p < 0.001) and AOPPs levels (r:- 0,384, p < 0.001). There was also a significant positive correlation between the serum IMA and PAB levels. Conclusions We clearly demonstrated that reactive oxygen species formation is significantly enhanced in APE. IMA and AOPPs may be used as clinical markers in the evaluation of APE severity in clinical practice. However, further studies with larger patient populations and longer follow-up periods are required to confirm the mechanisms underlying these findings.
National External Quality Assessment follow-up: 2010-2017 Turkish experience
(WALTER DE GRUYTER GMBH, 2019-01-01) Mercan, Ferzane; Serdar, Muhittin A.; Senes, Mehmet; Konukoglu, Dildar; Inal, Tamer Cevat; Alatas, Ozkan; Pinar, Asli; Savci, Ozlem; Guven, Muhammet; Gunduz, Mehmet; Egin, Ertugrul; Tipioglu, Yasal Onder; Tekin, Ahmet; Yucel, Dogan
Objective: Medical laboratories encounter critical obstacles in External Quality Assessment (EQA) practices that are key to assessment of the analytical period. Present study aims to unveil the challenges in nationwide interlaboratory harmonization and suggest practical solutions. Materials and methods: EQA results of 1941 laboratories participating in 18 different EQA-programs between 2010 and 2017 were examined. Standard Deviation Index (SDI) of each program calculated using 801,028 sample data from 24 different clinical chemical tests were used to conduct a process assessment. Results: There is a significant discrepancy in unsatisfactory performance ratio among different EAQ-programs with an average of 3.4\% (27,074 cases) between 2010 and 2017 and a decreasing trend (similar to 40-50\%) in 7-years. Programs with higher SDI display lower discrepancy rates. Reasons for unaccepted results appear to be data entry errors (8.27-22.2\%), material dilution errors (5-11.4\%), technical problems (3.76-7.9\%)