Browsing by Author "Korkmaz, Ayse"

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An Uncommon Cause of Hypernatremia in Very Low Birth Weight Premature Infants: Idiopathic Central Diabetes Insipidus
(AVES, 2021-01-01) Aktas, Selma; Kazanci, Ebru; Semiz, Serap; Korkmaz, Ayse
Central diabetes insipidus (CDI) is a water homeostasis disorder characterized by an inability to concentrate urine because of insufficient production of antidiuretic hormone. Dehydration with hypernatremia can occur during the neonatal period in preterm neonates in association with insensible water loss, high urine output, and reduced sodium excretion. A high index of suspicion is required to diagnose CDI in preterm neonates. We report two cases, who presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake. CDI diagnosis was confirmed by the therapeutic test with oral vasopressin analog. Investigations were all normal
Early Postnatal Metabolic Profile in Neonates With Different Birth Weight Status: A Pilot Study
(FRONTIERS MEDIA SA, 2021-01-01) Beken, Serdar; Abali, Saygin; Yildirim Saral, Neslihan; Guner, Bengisu; Dinc, Taha; Albayrak, Eda; Ersoy, Melike; Kilercik, Meltem; Halici, Muge; Bulbul, Ezgi; Kaya, Didem; Karabay, Melis; Ay, Zeynep Alize; Eksi, Gulten Zeynep; Benli Aksungar, Fehime; Korkmaz, Ayse; Serteser, Mustafa
Introduction: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this study, the relationship between intrauterine growth status and early metabolomics profile was evaluated. Materials and Methods: A single-center retrospective cohort study was conducted. Three hundred and sixty-one newborn infants were enrolled into the study, and they were grouped according to their birth weight percentile as small for gestational age (SGA, n = 69), appropriate for gestational age (AGA, n = 168), and large for gestational age (LGA, n = 124) infants. In all infants, amino acid and carnitine/acylcarnitine profiles with liquid chromatography-tandem mass spectrometry (LC-MS/MS) were recorded and compared between groups. Results: LGA infants had higher levels of glutamic acid and lower levels of ornithine, alanine, and glycine (p < 0.05) when compared with AGA infants. SGA infants had higher levels of alanine and glycine levels when compared with AGA and LGA infants. Total carnitine, C0, C2, C4, C5, C10:1, C18:1, C18:2, C14-OH, and C18:2-OH levels were significantly higher and C3 and C6-DC levels were lower in SGA infants (p < 0.05). LGA infants had higher C3 and C5:1 levels and lower C18:2 and C16:1-OH levels (p < 0.05). There were positive correlations between free carnitine and phenylalanine, arginine, methionine, alanine, and glycine levels (p < 0.05). Also, a positive correlation between ponderal index and C3, C5-DC, C14, and C14:1 and a negative correlation between ponderal index and ornithine, alanine, glycine, C16:1-OH, and C18:2 were shown. Conclusion: We demonstrated differences in metabolomics possibly reflecting the energy metabolism in newborn infants with intrauterine growth problems in the early postnatal period. These differences might be the footprints of metabolic disturbances in future adulthood.
Extremity Necrosis Due to Intrauterine Arterial Ischemia
(GALENOS YAYINCILIK, 2021-01-01) Beken, Serdar; Sariyilmaz, Kerim; Albayrak, Eda; Akcay, Arzu; Korkmaz, Ayse
Long-term follow-up of patients after acute kidney injury in the neonatal period: abnormal ambulatory blood pressure findings
(BMC, 2022-01-01) Akkoc, Gulsen; Duzova, Ali; Korkmaz, Ayse; Oguz, Berna; Yigit, Sule; Yurdakok, Murat
Background Data on the long-term effects of neonatal acute kidney injury (AKI) are limited. Methods We invited 302 children who had neonatal AKI and survived to hospital discharge
Neonatal Problems and Infancy Growth of Term SGA Infants: Does ``SGA'' Definition Need to Be Re-evaluated?
(FRONTIERS MEDIA SA, 2021-01-01) Abali, Saygin; Beken, Serdar; Albayrak, Eda; Inamlik, Aysegul; Bulum, Burcu; Bulbul, Ezgi; Eksi, Gulten Zeynep; Ay, Zeynep Alize; Karabay, Melis; Kaya, Didem; Halici, Muge; Semiz, Serap; Korkmaz, Ayse
Introduction: The exact definition of small-for-gestational-age (SGA) infant is still controversial among clinicians. In this study, we aimed to understand which definition is better in terms of establishing both early postnatal problems and growth. In this way, we compared early neonatal problems and infancy growth of term infants with birth weight (BW) < -2 SDS and with BW between 10th percentile (-1.28 SDS) and -2 SDS.Methods: A single center retrospective cohort study was conducted. Preterm infants, multiple gestations and newborns with any congenital anomalies were excluded from the study. Study group was defined as Group 1 (n = 37), infants BW < -2.00 SDS
Turkish Neonatal Society guideline on prevention and management of bronchopulmonary dysplasia
(TURKISH PEDIATRICS ASSOC, 2018-01-01) Arsan, Saadet; Korkmaz, Ayse; Oguz, Suna
Scientific and technological advances in perinatology and neonatology have led to an increased rate of survival and decreased incidences of various neonatal morbidities. However, the incidence of bronchopulmonary dysplasia has remained almost the same for years in very-low-birth-weight preterm infants. Although bronchopulmonary dysplasia is the leading cause of chronic respiratory morbidity in small preterms, no substantial improvement has been achieved in prevention and treatment strategies to date. Currently, postnatal very-low-dose corticosteroids, caffeine, and vitamin A seem to be the drugs of choice, and stem cell therapy appears to be the most promising treatment modality for the future. In this guideline, which was prepared by the Turkish Neonatal Society, recent evidence-based recommendations for the prevention and treatment of bronchopulmonary dysplasia are summarized.