Browsing by Author "O'Donoghue, Donal J."

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    The influence of multiple episodes of acute kidney injury on survival and progression to end stage kidney disease in patients with chronic kidney disease
    (PUBLIC LIBRARY SCIENCE, 2019-01-01) Sykes, Lynne; Asar, Ozgur; Ritchie, James; Raman, Maharajan; Vassallo, Diana; Alderson, Helen V.; O'Donoghue, Donal J.; Green, Darren; Diggle, Peter J.; Kalra, Philip A.
    Background Acute kidney injury (AKI) and chronic kidney disease (CKD) are common syndromes associated with significant morbidity, mortality and cost. The extent to which repeated AKI episodes may cumulatively affect the rate of progression of all-cause CKD has not previously been investigated. In this study, we explored the hypothesis that repeated episodes of AKI increase the rate of renal functional deterioration loss in patients recruited to a large, all-cause CKD cohort. Methods Patients from the Salford Kidney Study (SKS) were considered. Application of KDIGO criteria to all available laboratory measurements of renal function identified episodes of AKI. A competing risks model was specified for four survival events: Stage 1 AKI