Browsing by Author "Oran, Gulbin"

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    Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma
    (GALENOS YAYINCILIK, 2017-01-01) Naki, M. Murat; Oran, Gulbin; Tetikkurt, Seza Umit; Sonmez, Cavide Fatma; Turkmen, Ilknur; Kose, Faruk
    Objective: To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). Material and Methods: Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The association of MELF pattern with age, tumor grade, depth of myometrial invasion, and presence of lymphovascular space invasion (LVSI) was analyzed. Results: FIGO grade 2 and grade 1 tumors were evident in 53.0\% and 38.6\% of patients, respectively. Depth of myometrial invasion was <50\% in 72.0\% of patients, and LVSI was absent in 77.1\%. MELF pattern was confirmed in 35 (42.2\%) patients. Presence of MELF pattern was associated with significantly higher mean +/- standard deviation age (62.9 +/- 6.9) years vs. 58.9 +/- 9.1 years, p=0.033), and found to be more likely in patients with high-grade tumor (FIGO grade III