Browsing by Author "Sanli, Ahmet Necati"

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Olfactory Cleft Measurements and COVID-19-Related Anosmia
(SAGE PUBLICATIONS INC, 2021-01-01) Altundag, Aytug; Yildirim, Duzgun; Sanli, Deniz Esin Tekcan; Cayonu, Melih; Kandemirli, Sedat Giray; Sanli, Ahmet Necati; Duz, Ozge Arici; Saatci, Ozlem
Objective. This study aimed to investigate the differences in olfactory cleft (OC) morphology in coronavirus disease 2019 (COVID-19) anosmia compared to control subjects and postviral anosmia related to infection other than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study Design. Prospective. Setting. This study comprises 91 cases, including 24 cases with anosmia due to SARS-CoV-2, 38 patients with olfactory dysfunction (OD) due to viral infection other than SARS-CoV-2, and a control group of 29 normosmic cases. Methods. All cases had paranasal sinus computed tomography (CT), and cases with OD had magnetic resonance imaging (MRI) dedicated to the olfactory nerve. The OC width and volumes were measured on CT, and T2-weighted signal intensity (SI), olfactory bulb volumes, and olfactory sulcus depths were assessed on MRI. Results. This study showed 3 major findings: the right and left OC widths were significantly wider in anosmic patients due to SARS-CoV-2 (group 1) or OD due to non-SARS-CoV-2 viral infection (group 2) when compared to healthy controls. OC volumes were significantly higher in group 1 or 2 than in healthy controls, and T2 SI of OC area was higher in groups 1 and 2 than in healthy controls. There was no significant difference in olfactory bulb volumes and olfactory sulcus depths on MRI among groups 1 and 2. Conclusion. In this study, patients with COVID-19 anosmia had higher OC widths and volumes compared to control subjects. In addition, there was higher T2 SI of the olfactory bulb in COVID-19 anosmia compared to control subjects, suggesting underlying inflammatory changes. There was a significant negative correlation between these morphological findings and threshold discrimination identification scores.
Olfactory Cleft Width and Volumes in Patients with COVID-19 Anosmia
(KARGER, 2019-01-01) Tekcan Sanli, Deniz Esin; Sanli, Ahmet Necati; Kandemirli, Sedat Giray; Altundag, Aytug; Yildirim, Duzgun
Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia
(W B SAUNDERS CO-ELSEVIER INC, 2021-01-01) Sanli, Deniz Esin Tekcan; Altundag, Aytug; Kandemirli, Sedat Giray; Yildirim, Duzgun; Sanli, Ahmet Necati; Saatci, Ozlem; Kirisoglu, Ceyda Erel; Dikensoy, Oner; Murrja, Edvin; Yesil, Atakan; Bastan, Serdar; Karsidag, Tamer; Akinci, Ibrahim Ozkan; Ozkok, Sezen; Yilmaz, Eren; Tuzuner, Filiz; Kilercik, Meltem; Ljama, Taner
Background: An association between IL-6 levels and cytokine storm syndrome in COVID-19 patients has been suggested. Cases with higher IL-6 levels have more rapid progression and a higher complication rate. On the other hand, COVID-19 cases with anosmia have a milder course of the disease. Objective: We aimed to investigate whether there is a relationship between serum IL-6 levels and presence of anosmia in COVID-19 patients. Methods: Patients with a confirmed diagnosis of COVID-19 based on laboratory (PCR) were stratified into two groups based on presence of olfactory dysfunction (OD). In all cases with and without anosmia