Browsing by Author "Sezer, Engin"

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A Case Report of Syringocystadenoma Papilliferum Mimicking Basal Cell Carcinoma on the Face
(GALENOS YAYINCILIK, 2012-01-01) Sezer, Engin; Erkek, Emel; Sahin, Sedef
Syringocystadenoma papilliferum is clinically characterized by verrucous nodules or plaques, mainly observed on the scalp during childhood. Histopathologically, epidermal invagination showing luminal epithelial cells with decapitation secretion is diagnostic. Herein, we describe an unusual late-onset case of syringocystadenoma papilliferum mimicking basal cell carcinoma on the face.
Adult Type Xanthogranuloma: A Case Report
(GALENOS YAYINCILIK, 2011-01-01) Sezer, Engin; Erkek, Emel; Sahin, Sedef; Cetin, Emel Dikicioglu
Cutaneous xanthogranuloma is a dermatosis, clinically presenting as papules, nodules or plaques and histopathologically characterized by diffuse dermal infiltration of epithelioid cells with vesicular nuclei and conspicuous cytoplasm showing focal xanthomatous changes, and a mixed inflammation including eosinophils, neutrophils and lymphocytes. Although the disease is commonly observed in childhood, adult cases have also been reported and may cause confusion with various disorders histopathologically, including malignant melanoma. Herein, we report a case of adult type xanthogranuloma with reference to the literature.
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia
(INT DERMOSCOPY SOCIETY, 2018-01-01) Tokat, Fatma; Lehman, Julia S.; Sezer, Engin; Cetin, Emel Dikicioglu; Ince, Umit; Durmaz, Emel Ozturk
Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process. Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. We aimed to investigate the immunoreactivity of ALHE specimens for WT1 as well as glucose transporter protein 1 (GLUT1) immunohistochemistry, an important and sensitive marker for the diagnosis of infantile hemangioma, which recently has been described to label other hemangiomas, such as verrucous hemangioma. Material and methods: Clinical data and histopathological specimens from patients diagnosed with ALHE were reviewed, and immunohistochemical staining and microscopic analysis for WT-1 and GLUT1 were performed. Results: Intracytoplasmic endothelial staining of WT1 was detected in 19 of 20 ALHE specimens. GLUT1 was not detected in any ALHE specimen. Conclusions: We conclude that ALHE may represent a true hemangioma (i.e., benign vascular neoplasia) characterized by an eosinophil- and lymphocyte-rich inflammatory component as opposed to the reactive inflammatory dermatosis with a positive intracytoplasmic staining pattern for WT1. As far as we are aware, WT1 staining for ALHE has not been described to date.
Papular elastorrhexis: clinical perspectives
(DOVE MEDICAL PRESS LTD, 2018-01-01) Sezer, Engin; Durmaz, Emel Ozturk; Sahin, Sedef
First described by Bordas in 1987, papular elastorrhexis (PE) is a rare elastic fiber disorder of the skin characterized by multiple, discrete, asymptomatic, firm, nonfollicular, monomorphous, 1-5 mm, circumscribed, hypopigmented, oval to round papules, symmetrically distributed on the chest, abdomen, back, shoulders, arms, and thighs. The onset of the condition is usually in the first or second decade of life. PE appears to be an exceedingly rare entity, with 33 cases reported in the literature until now. However, the disorder might be underestimated probably because of its subtlety, asymptomatic course, and benign nature of clinical alterations, which can easily be confused with other dermatoses such as acne scars. Clinical and histopathological differential diagnosis of PE is broad and includes papular acne scars, eruptive collagenoma, disseminated lenticular dermatofibrosis (as a component of Buschke-Ollendorff syndrome), white fibrous papulosis of the neck, pseudoxanthoma elasticum, pseudoxanthoma elasticum-like papillary dermal elastolysis, middermal elastolysis, and perifollicular elastolysis. Treatment of PE is a matter of debate and no reliable curative option exists.
Relationship between retinal sensitivity and disease activity in patients with psoriasis vulgaris
(HOSPITAL CLINICAS, UNIV SAO PAULO, 2015-01-01) Demir, Helin Deniz; Kalkan, Goknur; Kurt, Semiha; Gunes, Alper; Sezer, Engin; Erkorkmaz, Unal
OBJECTIVES: Psoriasis is a hyperproliferative chronic inflammatory skin disease of unknown etiology and ocular structures and visual pathways can also be affected during the course of this disease. Subclinical optic neuritis has previously been observed in psoriatic patients in visual evoked potential studies. This trial was designed to evaluate retinal sensitivity in patients with psoriasis vulgaris. METHODS: A total of 40 eyes of 40 patients with chronic plaque-type psoriasis and 40 eyes of 40 age-and sex-matched control subjects were included in this study. The diagnosis of psoriasis was confirmed by skin biopsy. The severity was determined using the Psoriasis Area and Severity Index and the duration of the disease was recorded. After a full ophthalmological examination, including tests for color vision and pupil reactions, the visual field of each subject was assessed using both standard achromatic perimetry and short wavelength automated perimetry. RESULTS: The mean Psoriasis Area and Severity Index was 22.05 +/- 6.409. There were no significant differences in the visual field parameters of subjects versus controls using either method. There were correlations between disease severity and the mean deviations in standard achromatic perimetry and short wavelength automated perimetry and between disease severity and the corrected pattern standard deviation and pattern standard deviation of short wavelength automated perimetry (r = -0.363, r = -0.399, r = 0.515 and r = 0.369, respectively). CONCLUSIONS: Retinal sensitivity appears to be affected by the severity of psoriasis vulgaris.
Secretan Syndrome: A Fluctuating Case of Factitious Lymphedema
(QUADRANT HEALTHCOM INC, 2021-01-01) Demircioglu, Deniz; Durmaz, Emel Ozturk; Sezer, Engin; Sahin, Sedef
Terra firma-forme dermatosis
(MEDKNOW PUBLICATIONS \& MEDIA PVT LTD, 2012-01-01) Erkek, Emel; Sahin, Sedef; Cetin, Emel Dikicioglu; Sezer, Engin
Terra firma-forme dermatosis is characterized by `dirty' brown-grey cutaneous patches and plaques that can simply be eradicated by forceful swabbing with alcohol pads. The pathogenesis has been attributed to abnormal and delayed keratinization. Although affected patients present with typical lesions, the disorder is not well-known by dermatologists. In this report, we describe two patients with terra firma-forme dermatosis in the setting of xerosis cutis and atopic dermatitis. From a clinical point of view, we lay emphasis on its unique expression and diagnosis/treatment. From a histological perspective, we highlight its resemblance to dermatosis neglecta and speculate on the role of `neglect' in a patient with seemingly adequate hygiene. The role of urea containing emollients in the development of this disorder remains to be determined.