Browsing by Author "Turhan, Turan"

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    A short guideline on chronic kidney disease for medical laboratory practice
    (WALTER DE GRUYTER GMBH, 2016-01-01) Abusoglu, Sedat; Aydin, Ilknur; Bakar, Funda; Bekdemir, Tan; Gulbahar, Ozlem; Islekel, Huray; Ozarda, Yesim; Pektas, Macit; Pir, Kamil; Portakal, Oytun; Serdar, Muhittin; Turhan, Turan; Yucel, Dogan; Zengi, Oguzhan
    Chronic kidney disease (CKD) is asymptomatic in the early stage. Kidney function might be lost 90\% when the symptoms are overt. However, in case of early detection, progression of the disease can be prevented or delayed. If not detected it results in end stage renal disease. Therefore, the level of awareness about CKD should be increased. The role of medical laboratory is utmost important for the diagnosis and staging of CKD. In this paper, the main tasks of the laboratory specialists are described and the outlines are as follows. Creatinine assays should be traceable to internationally recognised reference materials and methods, specifically isotope dilution mass spectrometry. When reporting the creatinine result, eGFR should also be reported in adult (> 18 years) population. A warning expression should be included in the report form if eGFR result is <60 mL/min/1.73 m(2). eGFR values should be expressed quantitatively up to 90 mL/min/1.73 m(2) by CKD-EPI equation. Above 90 mL/min/1.73 m(2), eGFR values can be expressed quantitatively or >90 mL/min/1.73 m2. eGFR equations of the adult population should not be used for pediatric population. Different equations utilizing also patient height should be used. The enzymatic creatinine assay should be preferred. eGFR based on cystatin C can be used for confirmation in the pediatric population. Cystatin C measurements, at least when eGFR based on creatinine is not reliable and for confirmation should be encouraged. Proteinuria or albuminuria values should be measured in spot samples and reported in proportion to creatinine.
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    Determining biological variation of serum parathyroid hormone in healthy adults
    (CROATIAN SOC MEDICAL BIOCHEMISTRY \& LABORATORY MEDICINE, 2019-01-01) Ercan, Mujgan; Akbulut, Emis Deniz; Avci, Esin; Yucel, Cigdem; Oguz, Esra Firat; Turhan, Turan; Serdar, Muhittin
    Introduction: Measurement of parathyroid hormone (PTH) is essential in the investigation and management of calcium metabolism disorders. To assess the significance of any assay result when clinical decision making biological variation (BV) of the measurand must be taken into consideration. The aim of the present study is determining the BV parameters for serum PTH. Materials and methods: Blood samples were taken at weekly intervals from 20 healthy subjects for ten weeks in this prospective BV study. Serum ``intact PTH{''} concentrations were measured with electrochemiluminescence method. Biological variation parameters were estimated using the approach proposed by Fraser. Results: The values of within-subject biological variation (CVI), between-subject biological variation (CVG), analytical variation (CVA), reference change value (RCV) and individuality index (II) for serum PTH were 21.1\%, 24.9\%, 3.8\%, 59.4\% and 0.8\%, respectively. Within-subject biological variation and CVG were also determined according to gender separately