Browsing by Author "Ulus, Ozden Sila"

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Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study
(TURKISH SOC CARDIOLOGY, 2011-01-01) Buturak, Ali; Genc, Ahmet; Ulus, Ozden Sila; Duygu, Egemen; Okmen, Arda Sanli; Uyarel, Huseyin
Objective: To evaluate the effect of chronic biomass fuel (BMF) smoke exposure on peripheral endothelial functions. Methods: Forty-seven healthy subjects who have been exposed to BMF smoke since birth (mean age 31.6 +/- 6.8 years, 21 male) were enrolled in the present cross-sectional observational study. The control group consisted of 32 healthy subjects (mean age 27.9 +/- 4.4 years, 11 male). The carotid intima media thickness (CIMT), flow associated dilatation (FAD \%) and endothelium independent vasodilatation (GTN \%) were assessed in all subjects. The carotid CIMT was defined as the distance between the leading edge of the lumen intima and the media adventitia interfaces. FAD \% was defined as the percentage change in the internal diameter of the brachial artery during reactive hyperemia related to the baseline. GTN \% was defined as the change in diameter in response to the application of 400 mu g of glyceril trinitrate relative to the baseline scan at the end of the fourth minute. Statistical analysis was performed using Student's t-test, Chi-square test and Spearman rank order correlation analysis. Results: The average exposure time of the subjects to biomass fuel smoke was 31.7 +/- 6.6 years. They have been exposed to dung inhalation products meanly 8.3 +/- 1.8 months in a year seasonally. The average daily exposure time was 15.7 +/- 3.3 hours. CIMT values of the two groups were not statistically different from each other (0.47 +/- 0.09 vs. 0.49 +/- 0.06 mm, p=0.138). However, a markedly reduced FAD \% was determined in the study group (5.06 +/- 4.95 vs. 10.7 +/- 4.64, p < 0.001). And GTN \% of the BMF exposed group was significantly lower than the control group (14.41 +/- 8.47 vs. 21.85 +/- 7.87, p < 0.001). Conclusion: FAD \% and GTN \% are markedly reduced in the individuals who have been exposed to BMF smoke inhalation products. Therefore, chronic BMF smoke exposure may be a risk factor for the development of endothelial dysfunction. (Anadolu Kardiyol Derg 2011
Micro-dose Paranasal Computed Tomography is Valuable When Evaluating Diseases of the Paranasal Sinuses
(GALENOS YAYINCILIK, 2019-01-01) Ozbayrak, Mustafa; Ertas, Burak; Ulus, Ozden Sila; Ozdilek, Alper; Karaarslan, Ercan
Aim: We explored whether a reduction in the radiation dose affected the quality of diagnostic images generated using third-generation dual-source computed tomography (CT) running advanced third-generation iterative reconstruction software. Methods: From February to May 2015, 72 consecutive patients aged 16 to 64 years with clinically suspected sinusitis were randomly and prospectively enrolled and divided into two groups (standard or micro-dose CT). Anatomical landmarks and mucosal structures were independently evaluated by a radiologist and an otorhinolaryngologist using a four-point grading scale. Mean scores were calculated and compared. Results: All images were of diagnostic quality. The mean effective radiation dose was significantly lower in patients evaluated via the micro-dose protocol (group 2) than in those evaluated using the standard protocol (group 1) (p<0.05). The mean anatomical scores showed that all landmarks were very well-defined, with the exceptions of the uncinate attachment point and the ethmoid foramen (used to identify the ethmoid artery). The Wilcoxon signed rank test revealed no significant difference between the mean scores of the two observers for either group (p>0.05). Conclusion: The radiation dose to the paranasal sinus delivered during CT in patients with suspected sinusitis can be reduced to 0.003 mSv using third-generation dual-source CT running advanced iterative reconstruction software.