Browsing by Author "Yazgan Aksoy, Duygu"

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    Adiponectin levels decrease independently of body mass index and diabetes type after the normalization of hyperglycemia
    (TUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY, 2020-01-01) Metin Aksu, Nalan; Yazgan Aksoy, Duygu; Akkas, Meltem; Cinar, Nese; Ucar, Fatma; Yildiz, Okan Bulent; Usman, Aydan
    Background/aim: Acute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), because it is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acute hyperglycemic states and after normalization of blood glucose with insulin treatment. Materials and methods: Forty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia were included in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose with insulin treatment, and adiponectin levels were measured in both samples. Results: There were 21 female and 27 male patients with a median age of 58.7 +/- 18 years. All patients' blood glucose levels were normalized with insulin treatment according to international recommendations. Serum adiponectin levels decreased significantly after the normalization of blood glucose in the whole group. Adiponectin levels decreased from 28.9 +/- 16.5 to 12.1 +/- 10.9 mu g/mL (P < 0.0001) in the whole group. This decrease was independent of diabetes type and body mass index. Conclusion: Normalization of blood glucose in patients with hyperglycemia caused a decrease in adiponectin levels, independent of diabetes type and/or body weight in an acute emergency setting. Inhibited upregulation of adiponectin secretion and/or blunted suppressive effect of insulin due to hyperglycemia or exogenous insulin administration may have caused the decrease in adiponectin levels.
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    Osteoporozda Güncel Tedavi
    (Acıbadem Mehmet Ali Aydınlar Üniversitesi, 2016-01-01) Ünal, Mustafa; Yazgan Aksoy, Duygu; Güler, Serdar
    ÖZET Düşük kemik mineral yoğunluğu ve kemik dokunun mikro yapısında bozulma ile karakterize, kemik frajilitesin de ve kırık riskinde artışa neden olan sistemik bir hastalık olarak tanımlanan osteoporoz dünyada ve ülkemizde önemli bir sağlık sorunu haline gelmiştir. Özellikle postmenopozal kadınlarda olmak üzere milyonlarca insanı et kilemektedir. Yol açtığı kırıklarla yaşam kalitesini düşürmekte, ekonomik ve sosyal yükün yanı sıra morbidite ve mortaliteyi de artırmaktadır. Ortalama yaşam süresinin artması kronik hastalıklarla beraber osteoporoz görülme sıklığını da arttırmaktadır. osteoporozun tanısı ve tedavi prensipleri gözden geçirilmiş ve son kılavuzlar ışığında osteoporoza güncel bir yaklaşım ele alınmaya çalışılmıştır.