Araştırma Çıktıları

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Author: search.filters.author.Karsiyakali, NejdetHas files: Yes

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    Evaluation of Sleep Quality and Quantity of Patients with Benign Prostatic Hyperplasia Using the Medical Outcomes Study-sleep Scale
    (GALENOS YAYINCILIK, 2020-01-01) Sarikaya, Selcuk; Sarikaya, Fatma Gokcem; Karsiyakali, Nejdet; Selvi, Ismail; Senocak, Cagri; Bozkurt, Omer Faruk; Esperto, Francesco; Vurucu, Mustafa; Gurdal, Mesut
    Objective: This study aimed to evaluate the sleep quality and quantity of patients with benign prostate hyperplasia (BPH) and compare them with that of a control group using the Medical Outcomes Study-sleep scale (MOS-SS). Materials and Methods: The study included 114 consecutive men who were recruited between 2014 and 2018. Voiding patterns of patients with BPH were evaluated by free uroflowmetry, and symptom scores were evaluated using the International Prostate Symptom score (IPSS). Sleep quality and quantity of all patients were evaluated using the MOS-SS questionnaire. The participants were divided into two groups: 57 BPH patients (group 1) and 57 healthy individuals (group 2). They were compared statistically in terms of MOS-SS subdomains. The relationship between MOS-SS subdomains and IPSS, free uroflowmetry parameters, and post-voiding residual urine volume (PVR) was evaluated in BPH patients. Factors affecting the MOS-SS subdomains were also investigated. Results: The mean age of group 1 was higher than that of group 2 (67 +/- 9 vs 52 +/- 11 years, p<0.001). All MOS-SS subdomain scores except for snoring were adversely affected in group 1, and there was a statistically significant difference between the groups (p<0.001). A mild to moderate significant correlation was found between the MOS-SS subdomain scores and IPSS, free uroflowmetry parameters, and PVR. In multivariate analysis, free uroflowmetry parameters and PVR were found to be independent risk factors for predicting deterioration in the MOS-SS subdomains. Conclusion: It was observed that sleep quality and quantity were negatively affected in group 1. We recommend that sleep quality and quantity should be investigated especially in BPH patients with increased PVR levels and decreased free uroflowmetry parameters.
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    Evaluation of the Sexual Functioning of Individuals Living in Turkey During the COVID-19 Pandemic: An Internet-Based Nationwide Survey Study
    (ELSEVIER SCI LTD, 2021-01-01) Karsiyakali, Nejdet; Sahin, Yusuf; Ates, Huseyin Aytac; Okucu, Emrah; Karabay, Emre
    Introduction: Although many countries in the world prioritize self-isolation measures during the corona virus disease 2019 (COVID-19) pandemic period, the effects of this process on sexual functioning are not yet known. Aim: To evaluate the effects of the COVID-19 pandemic on the sexual functioning of individuals who declared no medical history of the COVID-19 disease. Methods: A total of 1,356 participants filled out an Internet-based survey between June 1 and June 20, 2020. The data from these participants were analyzed to determine sexual functioning in terms of sexual intercourse frequency and sexual desire during theCOVID-19 pandemic. Subgroups analyses were also performed, wherein the subgroups were developed according to the population density of the cities in which the participants lived to examine whether population density has any effect on the sexual functions of the participants during the COVID-19 pandemic. Main Outcome Measure: The study outcomes were obtained using a study-specific questionnaire to assess the changes in people's sexual functioning. Results: The mean age of the participants was 33.16 +/- 8.31 years. There was a statistically significant difference between the participants according to the decrease in the number of weekly sexual intercourses when they were compared in terms of smoking status, alcohol consumption, marital and parental status, being a health-care worker, having a regular sexual partner, and the working status during the COVID-19 pandemic (P <.05, for each). In the subgroup analyses, it was observed that there was a statistically significant difference between the groups for change in the number of sexual intercourses, the number of masturbations, and sexual desire during the COVID-19 pandemic (P <.05, for each). Conclusion: A decline in sexual functioning was observed during the COVID-19 pandemic period. Living in a metropolitan area was associated with a decline in both sexual intercourse frequency and sexual desire during the COVID-19 pandemic. Copyright (C) 2020, The Authors. Published by Elsevier Inc.
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    A Case of Eccrine Porocarcinoma Accompanying Renal Cell Carcinoma
    (GALENOS YAYINCILIK, 2021-01-01) Mansur, Ayse Tulin; Karsiyakali, Nejdet; Demirci, Gulsen Tukenmez; Koseoglu, Hikmet; Akman, Yavuz; Yildiz, Semsi
    In this case report, we present the coexistence of eccrine porocarcinoma (EPC) and renal cell carcinoma (RCC) in a 69-year-old male patient whose surgical resection pathology of the skin lesion in the right gluteal region was reported as EPC and concurrent radical nephrectomy pathology of the right renal mass was reported as RCC.
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    Identifying the predictors of estimated glomerular filtration rate after partial nephrectomy with a nonlinear regression model
    (WILEY, 2021-01-01) Karabay, Emre; Tosun, Cagatay; Karsiyakali, Nejdet; Kayar, Kemal; Aykan, Serdar; Aslan, Ahmet Ruknettin; Yucebas, Omer Ergin; Ozturk, Metin Ishak
    Purpose To evaluate the effect of partial nephrectomy on renal function and to identify predictors of estimated glomerular filtration rate (eGFR) at 6 months after partial nephrectomy. Methods Medical data of 154 consecutive patients who underwent partial nephrectomy for a renal mass between January 2015 and March 2020 were retrospectively analysed. The primary outcome measure was eGFR at 6 months postoperatively. An ordinary least regression analysis using a restricted cubic spline for continuous variables was performed to examine the association between primary outcome measure and candidate predictors. Results Of the patients, 66 (42.9\%) were females and 88 (57.1\%) were males with a median age of 60 (range, 50 to 67) years. The median baseline eGFR was 90.40 (range, 74.96 to 102.97) mL/min/1.73 m(2), while the median eGFR at 6 months was 77.12 (range, 61.06 to 91.93) mL/min/1.73 m(2) (P < .001). Baseline eGFR (regression coefficient (beta) = 22.7, 95\%CI: 18.8 to 26.5, P < .001) was found to be most significant predictor with the postoperative eGFR levels at 6 months. In addition, advanced tumour size (beta = -3.17, 95\%CI: -5.33 to -1.01, P < .001) and presence of hypertension (beta = -3.48, 95\%CI: -6.96 to -0.003, P = .049) were also found to be inversely associated with the postoperative eGFR levels at 6 months. Conclusion Baseline eGFR values, tumour size, and presence of hypertension are significant predictors of eGFR values in the mid-term in patients undergoing partial nephrectomy.
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    The Comparison of Conventional and Retzius-Sparing Robot-Assisted Radical Prostatectomy for Clinical, Pathological, and Oncological Outcomes
    (GALENOS YAYINCILIK, 2022-01-01) Karsiyakali, Nejdet; Ozgen, Mahir Bulent; Ozveren, Bora; Durak, Haydar; Saglican, Yesim; Turkeri, Levent
    Objective: This study aimed to assess and compare the conventional and Retzius-sparing robot-assisted radical prostatectomy (cRARP and RsRARP) in term of perioperative clinical, pathological, and oncological outcomes. Materials and Methods: This study included 238 consecutive male patients who underwent RARP between May 2008 and November 2020. RARP operations were performed by a single-surgeon. Patients were divided into groups according to the surgical approach and were statistically compared in terms of perioperative clinical, final pathological, and oncological outcomes. Results: The mean age of patients was 64 +/- 7 years. cRARP was performed in 134 (56.3\%) patients, whereas RsRARP in 104 (43.7\%). The frequency of patients with the American Society of Anesthesiologists Class-2 score was higher in the RsRARP group (p<0.001). The median surgery duration was 300 (270-360) min. The median surgery duration was shorter in RsRARP group (290 vs. 330 minute) (p<0.001). No difference was found between the groups in terms of estimated blood loss and postoperative complication rates (p=0.112 and p=0.182, respectively). No difference was found between the groups when they were compared for surgical margin positivity (p=0.453). Although not statistically significant, the frequency of surgical margin positivity with pT3a/pT3b disease was higher in patients who underwent cRARP (p=0.412 and p=0.261, respectively). At a median follow-up of 13 (6-36) months, no difference was found between the groups in terms of biochemical recurrence at months-3,-6,-9,-12,-18,-24, and-30, respectively (p>0.05, for each). Conclusion: RsRARP allows a safe operation with a shorter surgical time and similar surgical margin positivity, oncological outcomes, and complication rates compared to cRARP.
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    A Case of Unclassified Renal Cell Carcinoma Initially Considered as Translocation RCC and Review of Literature
    (GALENOS YAYINCILIK, 2021-01-01) Karsiyakali, Nejdet; Ozgen, Mahir Bulent; Ozveren, Bora; Ekici, Isin Dogan; Turkeri, Levent
    This case report aimed to review the literature on translocation renal cell carcinoma (tRCC), which is a rare form of kidney cancer and was the initial diagnosis of a recently treated patient. We report our findings in a 30-year-old female who underwent robot-assisted radical nephrectomy for an incidental right renal mass, which was reported as unclassified RCC at final pathologic evaluation after eliminating tRCC as differential diagnosis, and discuss the main aspects of tRCC based on current literature.
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    Increased Prostate Imaging-Reporting and Data System Scores in Multiparametric Magnetic Resonance Imaging May Predict More Extensive Disease in Radical Prostatectomy Specimens
    (GALENOS YAYINCILIK, 2021-01-01) Karsiyakali, Nejdet; Ozgen, Mahir Bulent; Ozveren, Bora; Akbal, Cem; Dincer, Alp; Durak, Haydar; Turkeri, Levent
    Objective: This study aimed to investigate the correlation between index lesion prostate imaging-reporting and data system (PI-RADS) version-2 score and histopathological outcomes of prostatectomy specimens. Materials and Methods: A total of 78 male patients with prostate cancer (PCa) treated with robot-assisted radical prostatectomy between August 2015 and June 2020 were included in this study. In this cohort, suspicious lesions on multiparametric magnetic resonance imaging (mpMRI) were scored according to PI-RADS version-2 criteria. MpMRI-targeted prostate biopsy was performed for all suspicious lesions with a PI-RADS score of >= 3 followed by systematic prostate biopsy. The relationship between index lesion PI-RADS score and histopathological outcomes of prostatectomy specimens were evaluated statistically. Results: The mean age of the patients was 65.0 +/- 7.0 years. The distribution of PI-RADS scores of 3, 4, and 5 of the index lesions were 6 (7.7\%), 29 (37.2\%), and 43 (55.1\%), respectively. Lower tumor volume and tumor volume ratio were observed in patients with a PI-RADS score of 3 when they were compared with patients with PI-RADS scores of 4 and PI-RADS-5 (p<0.001, for each). No significant correlation was found between index lesion PI-RADS score in mpMRI and clinically significant PCa in prostatectomy specimens (r<0.200, p>0.05). However, a significant correlation was observed between index lesion PI-RADS score and extracapsular extension (ECE), as well as seminal vesicle invasion (SVI) and pT stage (r=0.327, p=0.004