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    The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
    (WILEY, 2022-01-01) Adamina, Michel; Ademuyiwa, Adesoji; Adisa, Adewale; Bhangu, Aneel A.; Bravo, Ana Minaya; Cunha, Miguel F.; Emile, Sameh; Ghosh, Dhruva; Glasbey, James C.; Harris, Benjamin; Keller, Debby; Lawday, Samuel; Lederhuber, Hans; Leventoglu, Sezai; Li, Elizabeth; Modolo, Maria Marta; Mittal, Rohin; Mohan, Helen M.; Nepogodiev, Dmitri; Parreno-Sacdalan, Marie Dione; Pata, Francesco; Pockney, Peter; Rutegard, Martin; Simoes, Joana F. F.; Smart, Neil; Varghese, Chris; Siaw-Acheampong, Kwabena; Benson, Ruth A.; Bywater, Edward; Chaudhry, Daoud; Dawson, Brett E.; Evans, Jonathan P.; Gujjuri, Rohan R.; Heritage, Emily; Jones, Conor S.; Kamarajah, Sivesh K.; Khatri, Chetan; Khaw, Rachel A.; Keatley, James M.; Knight, Andrew; Smart, Neil J.; Minaya-Bravo, Ana; Gallo, Gaetano; Moug, Susan; Di Saverio, Salomone; Vallance, Abigail; Vimalchandra, Dale; Griffiths, Ewen A.; Evans, Richard P. T.; Townen, Philip; Roberts, Keith; McKay, Siobhan; Isaac, John; Satoi, Sohei; Edwards, John; Coonar, Aman S.; Marchbank, Adrian; Caruana, Edward J.; Layton, Georgia R.; Patel, Akshay; Brunelli, Alessandro; Ford, Samuel; Desai, Anant; Gronchi, Alessandro; Fiore, Marco; Almond, Max; Tirotta, Fabio; Dumitra, Sinziana; Kolias, Angelos; Price, Stephen J.; Fountain, Daniel M.; Jenkinson, Michael D.; Hutchinson, Peter; Marcus, Hani J.; Piper, Rory J.; Lippa, Laura; Servadei, Franco; Esene, Ignatius; Freyschlag, Christian; Neville, Iuri; Rosseau, Gail; Schaller, Karl; Demetriades, Andreas K.; Robertson, Faith; Alamri, Alex; Shaw, Richard; Schache, Andrew G.; Winter, Stuart C.; Ho, Michael; Nankivell, Paul; Biel, Juan Rey; Batstone, Martin; Ganly, Ian; Vidya, Raghavan; Wilkins, Alex; Singh, Jagdeep K.; Thekinkattil, Dinesh; Sundar, Sudha; Fotopoulou, Christina; Leung, Elaine Yl; Khan, Tabassum; Chiva, Luis; Sehouli, Jalid; Fagotti, Anna; Cohen, Paul; Gutelkin, Murat; Ghebre, Rahel; Konney, Thomas; Pareja, Rene; Bristow, Rob; Dowdy, Sean; Shylasree, T. S.; Seenivasagam, Rajkumar Kottayasamy; Ng, Joe; Fujiwar, Keiichi; Stewart, Grant D.; Lamb, Benjamin; Narahari, Krishna; McNeill, Alan; Colquhoun, Alexandra; McGrath, John S.; Bromage, Steve; Barod, Ravi; Kasivisvanathan, Veeru; Klatte, Tobias; Abbott, Tom E. F.; Abukhalaf, Sadi; Ademuyiwa, Adesoji O.; Agarwal, Arnav; Akkulak, Murat; Alameer, Ehab; Alderson, Derek; Alakaloko, Felix; Albertsmeier, Markus; Alser, Osaid; Alshaar, Muhammad; Alshryda, Sattar; Arnaud, Alexis P.; Augestad, Knut Magne; Ayasra, Faris; Azevedo, Jose; Bankhead-Kendall, Brittany K.; Barlow, Emma; Beard, David; Blanco-Colino, Ruth; Brar, Amanpreet; Breen, Kerry A.; Bretherton, Chris; Buarque, Igor Lima; Burke, Joshua; Chaar, Mohammad; Chakrabortee, Sohini; Christensen, Peter; Cox, Daniel; Cukier, Moises; Davidson, Giana H.; Drake, Thomas M.; Edwards, John G.; Elhadi, Muhammed; Farik, Shebani; Fitzgerald, J. Edward; Garmanova, Tatiana; Gomes, Gustavo Mendonca Ataide; Grecinos, Gustavo; Gruendl, Magdalena; Halkias, Constantine; Harrison, Ewen M.; Hisham, Intisar; Hutchinson, Peter J.; Hwang, Shelley; Isik, Arda; Jonker, Pascal; Kaafarani, Haytham M. A.; Kruijff, Schelto; Lawani, Ismail; Litvin, Andrey; Loehrer, Andrew; Loffler, Markus W.; Lorena, Maria Aguilera; Major, Piotr; Martin, Janet; Mashbari, Hassan N.; Mazingi, Dennis; Metallidis, Symeon; Moore, Rachel; Moszkowicz, David; Ng-Kamstra, Joshua S.; Maimbo, Mayaba; Negoi, Ionut; Niquen, Milagros; Ntirenganya, Faustin; Olivos, Maricarmen; Oussama, Kacimi; Outani, Oumaima; Rivera, Carlos Jose Perez; Pinkney, Thomas D.; van der Plas, Willemijn; Qureshi, Ahmad; Radenkovic, Dejan; Ramos-De La Medina, Antonio; Richards, Toby; Roslani, April C.; Segura-Sampedro, Juan Jose; Santos, Irene; Sayyed, Raza; Schache, Andrew; Schnitzbauer, Andreas A.; Seyi-Olajide, Justina O.; Sharma, Neil; Shaw, Catherine A.; Shu, Sebastian; Soreide, Kjetil; Spinelli, Antonino; Sund, Malin; Tabiri, Stephen; Townend, Philip; Tsoulfas, Georgios; van Ramshorst, Gabrielle H.; Vimalachandran, Dale; Warren, Oliver J.; Wedderburn, Duane; Wrigh, Naomi; Valenzuela I, J.; Alurralde, C.; Caram, E. L.; Eskinazi, D. G.; Badra, R.; Garcia, J. S.; Lucchini, S. M.; Vasey, C.; Watson, E.; Cecire, J.; Salindera, S.; Sutherland, A.; Ahn, J. H.; Chen, S.; Gauri, N.; Jang, S.; Jia, F.; Mulligan, C. S.; Yang, W.; Ye, G.; Zhang, H.; Moss, J.; Richards, T.; Thian, A.; Vo, U. G.; Bagraith, K.; Chan, E.; Ho, D.; Jeyarajan, E.; Jordan, S.; Nolan, G. J.; Von Papen, M.; Wullschleger, M.; Dawson, A. C.; Drane, A.; Egoroff, N.; Gani, J.; Lott, N.; Pockney, P.; Phan, D.; Townend, D.; Bong, C.; Gundara, J.; Bowman, S.; Guerra, G. R.; Gerns, N.; Riddell, A.; Dudi-Venkata, N. N.; Kroon, H. M.; Sammour, T.; Mitchell, D.; Swinson, B.; Waldron, A.; Walker, P.; Lun, E. W. Y.; Messner, F.; Ofner, D.; Emmanuel, K.; Grechenig, M.; Gruber, R.; Harald, M.; Jager, T.; Ohlberger, L.; Presl, J.; Wimmer, A.; Samadov, E.; Barker, D.; Boyce, R.; Doyle, A.; Eastmond, A.; Gill, R.; O'Shea, M.; Padmore, G.; Paquette, N.; Phillips, E.; St John, S.; Walkes, K.; Flamey, N.; Pattyn, P.; Ceelen, W.; Van de Putte, D.; Van Nieuwenhove, Y.; Van Ramshorst, G.; Willaert, W.; Oosterlinck, W.; Van den Eynde, J.; Van den Eynde, R.; Aguiar Jr., Junior S.; Marques, T.; Camara, P.; De Lima, R. K.; Della Giustina, E.; Hoffmann V, P.; Nacif, L.; Ferro, Carvalho C.; Gomes, G. M. A.; Buarque I, Lima; Leite, Lira dos Santos A.; Pol-Fachin, L.; Bezerra, Santos T.; Silva, A.; Silvestre, D.; Barros, Vieira A.; Laporte, G.; Salem, M.; Awada, Barakat J.; Ijichi, T. R.; Kim, N. J.; Marreiro, A.; Muller, B.; Nunes, R.; Bodanese, B.; Isoton, J. C.; de Sampaio, Regina L.; Vendrame, C.; Sokolov, M.; Gribnev, P.; Boutros, M.; Caminsky, N.; Ghitulescu, G.; Groot, G.; Persad, A.; Pham, H.; Wood, M.; Demyttenaere, S.; Garfinkle, R.; Brown, C.; Karimuddin, A.; Lee, N.; Liu, J.; Kia, Madani T.; Phang, P. T.; Raval, M.; Tom, K.; Martel, A.; Nessim, C.; Stevenson, J.; Al Riyami, S.; Bali, K.; Bigam, D.; Dajani, K.; Dell, A.; Bellolio, F.; Besser, N.; Grasset, E.; Inzunza, M.; Martinic, Quintana M.; Altamirano, Riquoir C.; Esquide, Ruiz M.; Arias-Amezquita, F.; Cetares, C.; Murgueitio, Cortes N.; Gomez-Mayorga, J. L.; Abadia, M.; Bonilla, A.; Facundo, H.; Guevara, O.; Mora, Herrera D. R.; Ramirez, Jimenez L. J.; Manrique, E.; Morales, Pinilla R. E.; Ferro, Rey M.; Cuasquen, Velasquez B. G.; Karlovic, D.; Krsul, D.; Zelic, M.; Dijan, E.; Katusic, Z.; Mihanovic, J.; Rakvin, I.; Almezghwi, H.; Arslan, K.; Ozant, A.; Ozcay, N.; Frantzeskou, K.; Gouvas, N.; Kokkinos, G.; Papatheodorou, P.; Pozotou, I.; Stavrinidou, O.; Yiallourou, A.; Martinek, L.; Skrovina, M.; Szubota, I.; Peteja, M.; Zatecky, J.; Avlund, T.; Christensen, P.; Harbjerg, J. L.; Iversen, L. H.; Kjaer, D. W.; Kristensen, H. O.; Mekhael, M.; Ebbehoj, A. L.; Krarup, P.; Schlesinger, N.; Smith, H.; Crespo, A.; Diaz, P.; Rivas, R.; Tactuk, N.; El Kassas, M.; Omar, W.; Tawheed, A.; Talaat, M.; Abdelsamed, A.; Azzam, A. Y.; Salem, H.; Seleim, A.; Al Sayed, M.; Ashoush, F.; Elazzazy, E.; Essam, E.; Ewedah, M.; Hassan, E.; Metwalli, M.; Mourad, M.; Qatora, M. S.; Sabry, A.; Samih, A.; Abdelaal, Samir A.; Shehata, S.; Shenit, K.; Attia, D.; Kamal, N.; Osman, N.; Alaa, S.; Hamza, H. M.; Elghazaly, M. S.; Mohammed, M. M.; Nageh, M. A.; Saad, M. M.; Yousof, E. A.; Eldaly, A.; Alrahawy, M.; Sakr, A.; Soliman, H.; Soltan, H.; Amira, G.; Sallam, I.; Sherief, M.; Sherif, A.; Ghaly, G.; Hamdy, R.; Morsi, A.; Sherif, G.; Abdeldayem, H.; Salama I, Abdelkader; Balabel, M.; Fayed, Y.; Sherif, Ahmed Elshawadfy; Elmorsi, R.; Refky, B.; Bekele, K.; Kauppila, J. H.; Sarjanoja, E.; Helminen, O.; Huhta, H.; Beyrne, C.; Jouffret, L.; Marie-Macron, L.; Fredon, F.; Roux, A.; Lakkis, Z.; Manfredelli, S.; Chebaro, A.; El Amrani, M.; Lecolle, K.; Piessen, G.; Eveno, C.; Noiret, B.; Pruvot, Veziant J.; Zerbib, P.; Ballouhey, Q.; Barrat, B.; Taibi, A.; Bergeat, D.; Merdrignac, A.; Le Roy, B.; Perotto, L. O.; Scalabre, A.; Aime, A.; Ezanno, A. C.; Malgras, B.; Bouche, P. A.; Tzedakis, S.; Cotte, E.; Glehen, O.; Bendjemar, L.; Braham, H.; Charre, L.; El Arbi, N.; Police, A.; Volpin, E.; D'Urso, A.; Mutter, D.; Seeliger, B.; Bonnet, S.; Denet, C.; Fuks, D.; Laforest, A.; Pourcher, G.; Seguin-givelet, A.; Tribillon, E.; Duchalais, E.; Bork, U.; Fritzmann, J.; Praetorius, C.; Weitz, J.; Welsch, T.; Beyer, K.; Kamphues, C.; Lauscher, J.; Loch, F. N.; Schineis, C.; Albertsmeier, M.; Kappenberger, A.; Schiergens, T.; Werner, J.; Becker, R.; Jonescheit, J.; Pergolini, I.; Reim, D.; Herzberg, J.; Honarpisheh, H.; Strate, T.; Boeker, C.; Hakami, I.; Jw, Mall; Nowak, K.; Reinhard, T.; Kleeff, J.; Michalski, C.; Ronellenfitsch, U.; Bertolani, E.; Konigsrainer, A.; Loffler, M. W.; Quante, M.; Steidle, C.; Yurttas, C.; Izbicki, J.; Nitschke, C.; Perez, D.; Uzunoglu, F. G.; Antonakis, P.; Contis, I.; Dellaportas, D.; Gklavas, A.; Konstadoulakis, M.; Memos, N.; Papaconstantinou, I.; Polydorou, A.; Theodosopoulos, T.; Vezakis, A.; Antonopoulou I, M.; Manatakis, D. K.; Tasis, N.; Arkadopoulos, N.; Danias, N.; Economopoulou, P.; Frountzas, M.; Kokoropoulos, P.; Larentzakis, A.; Michalopoulos, N.; Parasyris, S.; Selmani, J.; Sidiropoulos, T.; Vassiliu, P.; Bouchagier, K.; Klimopoulos, S.; Paspaliari, D.; Stylianidis, G.; Akrivou, D.; Baxevanidou, K.; Bouliaris, K.; Chatzikomnitsa, P.; Delinasios, G.; Doudakmanis, C.; Efthimiou, M.; Giaglaras, A.; Kalfountzos, C.; Kolla, C.; Koukoulis, G.; Zervas, K.; Zourntou, S.; Baloyiannis, I.; Diamantis, A.; Perivoliotis, K.; Tzovaras, G.; Christidis, P.; Ioannidis, O.; Loutzidou, L.; Karaitianos, I. G.; Geroukalis, A.; Baili, E.; Charalabopoulos, A.; Liakakos, T.; Schizas, D.; Spartalis, E.; Syllaios, A.; Zografos, C.; Christou, C.; Papadopoulos, V.; Tooulias, A.; Tsoulfas, G.; Athanasakis, E.; Chrysos, E.; Tsiaoussis, I.; Xenaki, S.; Xynos, E.; Futaba, K.; Ho, M. F.; Hon, S.; Mak, T. W. C.; Ng, S.; Foo, C. C.; Banky, B.; Susztak, N.; Misra, S.; Pareek, P.; Vishnoi, J. R.; Jain, A.; Mishra, S.; Mishra, T.; Mitra, J. K.; Muduly, D.; Agrawal, A.; Garg, P. K.; Seenivasagam, Kottayasamy R.; Majumdar, K. S.; Mishra, N.; Singh, M. P.; Patnaik, Chyau S.; Rao, S.; Reddy, P.; Saksena, A. R.; Seshadri, Ayloor R.; Haque, P. D.; Jeyaraj, P.; Veetil, Kannummal S.; Mahajan, A.; Devarakonda, S.; Jesudason, M. R.; Mittal, R.; Moorthy, M.; Yezzaji, H.; Aggarwal, M.; Dhamija, P.; Kumar, A.; Chisthi, M.; George, G.; Kollengode, V. V.; Kuttanchettiyar, K. G.; Yadev, I.; Dharanipragada, K.; Kalayarasan, R.; Penumadu, P.; Mathew, S.; Akhtar, N.; Chaturvedi, A.; Gupta, S.; Kumar, V.; Rajan, S.; Agrawal, N.; Arora, A.; Chaturvedi, H.; Jain, M.; Kumar, S.; Singh, S.; Bhat, G. A.; Chowdri, N.; Mehraj, A.; Parray, F. Q.; Shah, Z. A.; Wani, R.; Ahmed, Z.; Bhat, M. A.; Laharwal, A.; Mahmood, M.; Mir, I.; Mohammad, Z.; Muzamil, J.; Rashid, A.; Singh, R.; Ahmed, A.; Jain, D.; Pipara, A.; Desoouza, A.; Pandey, D.; Pramesh, C. S.; Saklani, A.; Islam, A. A.; Kembuan, G.; Pajan, H.; Aremu, M.; Canas-Martinez, A.; Cullivan, O.; Murphy, C.; Owens, P.; Pickett, L.; Corrigan, M.; Daly, A.; Fleming, C. A.; Jordan, P.; Kayyal, M. Y.; Killeen, S.; Lynch, N.; O'Brien, S.; Syed, W. A. S.; Vernon, L.; Hanly, A.; Heneghan, H.; Kennelly, R.; Martin, S. T.; Winter, D.; Fahey, B. A.; Larkin, J.; Mccormick, P.; Mehigan, B. J.; Mohan, H.; Shokuhi, P.; Smith, J.; Bashir, Y.; Bass, G.; Connelly, T.; Creavin, B.; Earley, H.; Elliott, J. A.; Gillis, A. E.; Kavanagh, D.; Neary, P.; O'Riordan, J.; Reynolds, I. S.; Rice, D.; Ridgway, P. F.; Umair, M.; Whelan, M.; Corless, K.; Finnegan, L.; Fowler, A.; Hogan, A.; Lowery, A.; McKevitt, K.; Nugent, E.; Ryan, E. J.; Coffey, J. C.; Cunningham, R. M.; Devine, M.; Nally, D.; Peirce, C.; Hardy, N. P.; Neary, P. M.; O'Malley, S.; Ryan, M.; Gaziants, V.; Gold-Deutch, R.; Lavy, R.; Zmora, O.; Macina, S.; Mariani, N. M.; Opocher, E.; Ceretti, Pisani A.; Bianco, F.; Marino, M.; Marino V, M.; Mirabella, A.; Vaccarella, G.; Sena, G.; Agostini, C.; Alemanno, G.; Bartolini, I.; Bergamini, C.; Bruscino, A.; De Vincenti, R.; Di Bella, A.; Fortuna, L.; Maltinti, G.; Muiesan, P.; Prosperi, P.; Ringressi, M. N.; Risaliti, M.; Taddei, A.; Tucci, R.; Campagnaro, T.; Guglielmi, A.; Pedrazzani, C.; Rattizzato, S.; Ruzzenente, A.; Turri, G.; Altomare, D. F.; Papagni, V.; Picciariello, A.; Bellora, P.; D'Aloisio, G.; Ferrari, M.; Francone, E.; Gentilli, S.; Nikaj, H.; Bianchini, M.; Chiarugi, M.; Coccolini, F.; Cremonini, C.; Di Franco, G.; Furbetta, N.; Gianardi, D.; Guadagni, S.; Morelli, L.; Musetti, S.; Palmeri, M.; Tartaglia, D.; Anania, G.; Carcoforo, P.; Chiozza, M.; De Troia, A.; Radica, Koleva M.; Portinari, M.; Sibilla, M. G.; Urbani, A.; Fabbri, N.; Feo V, C.; Gennari, S.; Parini, S.; Righini, E.; Annessi, V.; Ruiz, Castro C.; Giunta, A.; Montella, M. T.; Zizzo, M.; Grossi, U.; Novello, S.; Romano, M.; Rossi, S.; Zanus, G.; Esposito, G.; Frongia, F.; Pisanu, A.; Podda, M.; Belluco, C.; Lauretta, A.; Montori, G.; Moras, L.; Olivieri, M.; Feo, C. F.; Perra, T.; Porcu, A.; Scanu, A. M.; Aversano, A.; Carbone, F.; Delrio, P.; Di Lauro, K.; Bucci, Fares A.; Rega, D.; Spiezio, G.; Pirozzolo, G.; Recordare, A.; Vignotto, C.; Calabro, M.; Farnesi, F.; Lunghi, E. G.; Muratore, A.; Federico, Pipitone N. S.; De Palma, G.; Luglio, G.; Pagano, G.; Tropeano, F. P.; Baldari, L.; Boni, L.; Cassinotti, E.; Cosimelli, M.; Fiore, M.; Guaglio, M.; Sorrentino, L.; Agnes, A.; Alfieri, S.; Belia, F.; Biondi, A.; Cozza, V.; D'Ugo, D.; De Simone, V.; Litta, F.; Lorenzon, L.; Marra, A. A.; Marzi, F.; Parello, A.; Persiani, R.; Ratto, C.; Rosa, F.; Scrima, O.; Sganga, G.; Belli, A.; Izzo, F.; Patrone, R.; Foppa, C.; Carvello, M. M.; De Lucia, F.; Spinelli, A.; Aprile, A.; Batistotti, P.; Massobrio, A.; Pertile, D.; Scabini, S.; Soriero, D.; Garberini, De Manzoni A.; Mazzotti, F.; Pasini, F.; Ugolini, G.; Barone, R.; Birolo, S. L.; Caccetta, M.; Deirino, A.; Garino, M.; Grasso, M.; Marafante, C.; Masciandaro, A.; Moggia, E.; Mungo, S.; Murgese, A.; Raggio, E.; Federico, P.; Maida, P.; Marra, E.; Marte, G.; Petrillo, A.; Tammaro, P.; Tufo, A.; Berselli, M.; Borroni, G.; Cocozza, E.; Conti, L.; Desio, M.; Rizzi, A.; Baldi, C.; Corbellini, C.; Sampietro, G. M.; Bordoni, P.; Clarizia, G.; Fleres, F.; Franzini, M.; Grechi, A.; Longhini, A.; Spolini, A.; Baldini, E.; Capelli, P.; Isolani, S. M.; Ribolla, M.; Bondurri, A.; Colombo, F.; Ferrario, L.; Guerci, C.; Maffioli, A.; Armao, T.; Ballabio, M.; Bisagni, P.; Longhi, M.; Madonini, M.; Impellizzeri, H.; Inama, M.; Moretto, G.; Mochet, S.; Usai, A.; Incollingo, P.; Giacometti, M.; Zonta, S.; Cosentino, Marino L.; Sagnotta, A.; Lc, Nespoli; Tamini, N.; Anastasi, A.; Bartalucci, B.; Bellacci, A.; Canonico, G.; Capezzuoli, L.; Di Martino, C.; Ipponi, P.; Linari, C.; Montelatici, M.; Nelli, T.; Spagni, G.; Tirloni, L.; Vitali, A.; Abate, E.; Casati, M.; Laface, L.; Schiavo, M.; Arminio, A.; Cotoia, A.; Lizzi, V.; Vovola, F.; Vergari, R.; D'Ugo, S.; Depalma, N.; Spampinato, M. G.; Annicchiarico, A.; Catena, F.; Giuffrida, M.; Perrone, G.; Baronio, G.; Carissimi, F.; Montuori, M.; Pinotti, E.; Brachini, G.; Chiappini, A.; Cicerchia, P. M.; Cirillo, B.; De Toma, G.; Fiori, E.; Fonsi, G. B.; Iannone, I.; La Torre, F.; Lapolla, P.; Meneghini, S.; Mingoli, A.; Sapienza, P.; Zambon, M.; Capolupo, G. T.; Carannante, F.; Mazzotta, E.; Gattolin, A.; Migliore, M.; Rimonda, R.; Sasia, D.; Travaglio, E.; Chessa, A.; Fiorini, A.; Norcini, C.; Colletti, G.; Confalonieri, M.; Costanzi, A.; Frattaruolo, C.; Mari, G.; Monteleone, M.; Locatelli, A.; Riva, C.; Balconi, A.; De Nardi, P.; Parise, P.; Vignali, A.; Belvedere, A.; Bernante, P.; Droghetti, M.; Jovine, E.; Neri, J.; Parlanti, D.; Pezzuto, A. P.; Poggioli, G.; Rottoli, M.; Russo, I. S.; Tanzanu, M.; Violante, T.; Borghi, F.; Cianflocca, D.; Grimaldi, Di Maria S.; Donati, D.; Gelarda, E.; Giraudo, G.; Giuffrida, M. C.; Marano, A.; Palagi, S.; Pellegrino, L.; Peluso, C.; Testa, V.; Agresta, F.; Prando, D.; Zese, M.; Armatura, G.; Frena, A.; Bertelli, G.; Marinello, P.; Notte, F.; Scotton, G.; Cervellera, M.; Gori, A.; Sartarelli, L.; Tonini, V.; Gallo, G.; Sammarco, G.; Vescio, G.; Di Marzo, F.; Kanemitsu, Y.; Moritani, K.; Al Abdallah, M.; Ayasra, F.; Ayasra, Y.; Qasem, A.; Fahmawee, T.; Hmedat, A.; Obeidat, K.; Abou Chaar, M. K.; Al-Masri, M.; Al-Najjar, H.; Alawneh, F.; Aldokali, N.; Senossi, O.; Subhi, M. T.; Algallai, M.; Alwarfly, S.; AlZAEDE, S.; Gahwagi, M.; Moftah, M.; Burgan, D.; Kamoka, E.; Kilani I, A.; Abdelkabir, M.; Altomi, I.; Abdulwahed, E.; Alshareea, E.; Aribi, N.; Aribi, S.; Biala, M.; Ghamgh, R.; Alsoufi, A.; Ellojli, I.; Kredan, A.; Msherghi, A.; Alshareef, K.; Alkadiki, Ghadah Z.; Almaadany, Faraj S.; Bradulskis, S.; Dainius, E.; Kubiliute, E.; Parseliunas, A.; Subocius, A.; Venskutonis, D.; Rasoaherinomenjanahary, F.; Razafindrahita, J. B.; Samison, L. H.; Ngo, C. W.; Ramasamy, S.; Hamdan, K. H.; Razali I, Md; Tan, J. A.; Thanapal, M. R.; Choong, E.; Lim, R. Z. M.; Sahid, Nik Amin; Hayati, F.; Jayasilan, J.; Rk, Sriram; Subramaniam, S.; Ibrahim, A. F.; Jusoh, Che A.; Hussain, A. H.; Sidek, Mohamed A. S.; Yunus, Mohd M. F.; Soh, J. Y.; Wong, M. P.; Zakaria, A. D.; Zakaria, Z.; Azman, Mohd Z. A.; Fathi, N. Q.; Roslani, A. C.; Xavier, R.; Alvarez, M. R.; Cordera, F.; Hernandez, R.; Martinez, Soule C. E.; Hasan, Aboharp Z.; Otoniel, L. R.; Duran, Sosa E. E.; Melchor-Ruan, J.; Banuelos, Romero E.; Vilar-Compte, D.; Buerba, G. A.; Mercado, M. A.; Posadas-Trujillo, O. E.; Salgado-Nesme, N.; Sarre, C.; Amrani, L.; Benkabbou, A.; El Ahmadi, B.; El Bouazizi, Y.; Belkhadir, Z. H.; Ghannam, A.; Majbar, A. M.; Mohsine, R.; Souadka, A.; Hompes, R.; Meima-van Praag, E. M.; Pronk, A. J. M.; Sharabiany, S.; Grotenhuis, B. A.; Hartveld, L.; Ebben, L.; Kuiper, S.; Melenhorst, J.; Poeze, M.; Posma-Bouman, L.; Derksen, T.; Franken, J.; Oosterling, S.; Konsten, J.; Van Heinsbergen, M.; Adeyeye, A.; Enoch, E.; Nwabuoku, S. E.; Sholadoye, T. T.; Tolani, M. A.; Olaogun, J.; Abiyere, H.; Babalola, O.; Okunlola, A.; Sani, Ali S.; Chinda, J.; Garba, S.; Mshelbwala, P.; Olori, S.; Olute, A.; Osagie, O.; Ogolekwu I, Pius; Umar, A.; Lo, Abdur-Rahman; Jo, Bello; Olasehinde, O.; Popoola, A. 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K.; Yanishev, A.; Litvin, A.; Litvina, Y.; Provozina, A.; Agapov, M.; Garmanova, T.; Kazachenko, E.; Markaryan, D.; Galliamov, E.; Kakotkin, V.; Kubyshkin, V.; Semina, E.; Kamalov, A.; Novikova, A.; Zakharenko, A.; Alshahrani, M.; Alsharif, F.; Eskander, M.; Majrashi, S.; Mashat, A.; Alharthi, M.; Aljiffry, M.; Basendowah, M.; Malibary, N.; Nassif, M.; Samkari, A.; Trabulsi, N.; Azab, A. M.; Alqahtani, D.; Jaloun, H.; Mudawi, I.; Al Awwad, S.; Alghamdi, M.; Alnumani, T.; Awad, S.; Sharara, I. 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A.; Kara, H.; Karahasanoglu, T.; Uras, C.; Akbas, A.; Altinel, Y.; Calikoglu, F.; Ercan, G.; Ercetin, C.; Meric, S.; Tokocin, M.; Vartanoglu, T.; Yigitbas, H.; Dogangun, M.; Iflazoglu, N.; Cennet, O.; Ha, Dincer; Erol, T.; Alhamed, A.; Ergun, S.; Sanli, A. N.; Uludag, S. S.; Velidedeoglu, M.; Zengin, A. K.; Kara, Y.; Bozkurt, M. A.; Kocatas, A.; Eyuboglu, K.; Guner, A.; Usta, M. A.; Balik, E.; Bugra, D.; Kulle, C. B.; Guler, S. A.; Tatar, O. C.; Utkan, N. Z.; Yildirim, A.; Yuksel, E.; Abbasov, A.; Yanar, H.; Akin, E.; Altintoprak, F.; Cakmak, G.; Demir, H.; Dikicier, E.; Firat, N.; Gonullu, E.; Kamburoglu, M. B.; Kucuk, I. F.; Mantoglu, B.; Kucuk, G. O.; Uyanik, M. S.; Goksoy, B.; Bozkurt, E.; Capkinoglu, E.; Guven, O.; Mihmanli, M.; Omeroglu, S.; Tanal, M.; Yetkin, G.; Akalin, M.; Arican, C.; Avci, E. 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L.; Smith, C.; Vimalachandran, D.; Emslie, K.; Pl, Labib; Minto, G.; Natale, J.; Panahi, P.; Rogers, L. J.; Abubakar, A.; Rahman, Akhter M. M.; O'Brien, H.; Sasapu, K.; Ng, H. J.; Day, A.; Hunt, A.; Laskar, N.; Gupta, A.; Steinke, J.; Thrumurthy, S.; Massie, E.; McGivern, K.; Rutherford, D.; Wilson, M.; Bacarese-Hamilton, T.; Ip, M.; James, A.; Salerno, G.; Stockdale, T.; Handa, S.; Kaushal, M.; Kler, A.; Patel, P.; Redfern, J.; Tezas, S.; Aawsaj, Y.; Barry, C.; Blackwell, L.; Emerson, H.; Fisher, A.; Katory, M.; Mustafa, A.; Kretzmer, L.; Lalou, L.; Manku, B.; Parwaiz, I.; Stafford, J.; Abdelkarim, M.; Asqalan, A.; Gala, T.; Ibrahim, S.; Maw, A.; Mithany, R.; Morgan, R.; Venkatesan, Sundaram G.; Banfield, D.; Boal, M.; Brown, O.; Dean, H.; Boulton, A. J.; Hardie, C. M.; McNaught, C.; Karandikar, S.; Naumann, D.; Chen, F.; Cheung, J.; Ayorinde, J.; Chase, T.; Cuming, T.; Ghanbari, A.; Humphreys, L.; Tayeh, S.; Ibrahim, Aboelkassem A.; Evans, C.; Ikram, H.; Loubani, M.; Nazir, S.; Robinson, A.; Sehgal, T.; Wilkins, A.; Dixon, J.; Jha, M.; Thulasiraman V, S.; Viswanath, Y.; Curl-Roper, T.; Delimpalta, C.; Liao, C. C. L.; Velchuru, V.; Westwood, E.; Bond-Smith, G.; Mastoridis, S.; Tebala, G. D.; Verberne, C.; Anscomb, N.; Baldwin-Smith, R.; Davies, M.; Grainger, C.; Haji, A.; Haq, A.; Nunoo-Mensah, J. W.; Rizk, M.; Bhatti I, M.; Boyd-Carson, H.; Elsey, E.; Gemmill, E.; Herrod, P.; MohammedJibreel, M.; Lenzi, E.; Saafan, T.; Sapre, D.; Sian, T.; Watson, N.; Athanasiou, A.; Burke, J.; Costigan, F.; Elkadi, H.; Johnstone, J.; Nahm, C.; Annamalai, S.; Ashmore, C.; Kourdouli, A.; Chean, C. S.; Dharamavaram, S.; Kulkarni, N.; Pereira, I.; Shanthakunalan, K.; Srikumar, B.; Askari, A.; Cirocchi, N.; Kudchadkar, S.; Patel, K.; Sagar, J.; Talwar, R.; Abdalla, M.; Ismail, O.; Newton, K.; Stylianides, N.; Aderombi, A.; Bajomo, O.; Beatson, K.; Garrett V, W.; Ng, V.; Al-Habsi, R.; Divya, G. S.; Dixon, F.; Keeler, B. D.; Egan, R. J.; Fabre, I.; Harries, R.; Li, Z.; Parkins, K.; Spencer, N.; Thompson, D.; Gemmell, C.; Grieco, C.; Hunt, L.; Ali, Mahmoud F.; Seebah, K.; Shaikh, I.; Sreedharan, L.; Youssef, M.; Shah, J.; Baguley, M.; Heer, B.; Rogers, M.; Woods, R.; Mills, S. J.; Sahnan, K.; Ahmed, M. E.; Si, Bukhari; Illingworth, B.; Kanthasamy, S.; Knights, E.; Sl, Ong; Pujari, R.; Tan, K. H. M.; Vanker, R.; Michel, M.; Patil, S.; Ravindran, S.; Sarveswaran, J.; Scott, L.; Khan, J.; Bhangu, A.; Ld, Cato; Kamal, M.; Kulkarni, R.; Parente, A.; Saeed, S.; Vijayan, D.; English, C.; Evans, J.; Fell, A.; Halkias, C.; Merh, R.; Nikolaou, S.; Kaul, S.; Khan, A. H.; Khan, F.; Mukherjee, S.; Patel, M.; Sarigul, M.; Adiamah, A.; Brewer, H.; Chowdhury, A.; Humes, D.; Jackman, J.; Koh, A.; Lewis-Lloyd, C.; Oyende, O.; Reilly, J.; Worku, D.; Bisset, C.; Moug, S.; Chadha, R.; Math, S.; Sarantitis, I.; Timbrell, S.; Vitone, L.; Faulkner, G.; Brixton, G.; Findlay, L.; Majkowska, A.; Manson, J.; Potter, R.; Bhalla, A.; Chia, Z.; Daliya, P.; Grimley, E.; Malcolm, F. L.; Theophilidou, E.; Daniels, I. R.; Fowler, G. E.; Massey, L. H.; McDermott, F. D.; Rajaretnam, N.; Angamuthu, N.; Chowdhury, S.; Gilliland, J.; Hart, C.; Knowles, J.; Mirnezami, R.; Varcada, M.; Beamish, A. J.; Magowan, D.; Nassa, H.; Price, C.; Smith, L.; Solari, F.; Tang, A. M.; Williams, G.; Davies, E.; Hawkin, P.; Raymond, T.; Ryska, O.; Baron, R.; Gahunia, S.; McNicol, F.; Russ, J.; Szatmary, P.; Thomas, A.; Jayasinghe, J. D.; Knowles, C.; Ledesma, F. S.; Minicozzi, A.; Navaratne, L.; Ramamoorthy, R.; Sohrabi, C.; Thaha, M. A.; Venn, M.; Atherton, R.; Brocklehurst, M.; McAleer, J.; Parkin, E.; Aladeojebi, A.; Ali, M.; Gaunt, A.; Hammer, C.; Stebbing, J.; Coomber, E.; Williams, O.; Bunni, J.; Fairhurst, K.; Mitchell, S.; Richards, S.; Hraishawi, I.; McIlmunn, C.; McIntosh, S.; Bhasin, S.; Bodla, A. S.; Burahee, A.; Crichton, A.; Fossett, R.; Yassin, N.; Barlow, C.; Ding, D.; Foster, J.; Longstaff, L.; Brown, S. R.; Lee, M.; Newman, T.; Steele, C.; Baker, A.; Konstantinou, C.; Ramcharan, S.; Wilkin, R. J. W.; Colvin V, H.; Shakoor, Z.; Lawday, S.; Lyons, A.; Newman, S.; Chung, E.; Hagger, R.; Hainsworth, A.; Karim, A.; Owen, H.; Ramwell, A.; Williams, K.; Hall, J.; Harris, G.; Royle, T.; Lj, Watson; Asaad, P.; Brown, B.; Duff, S.; Khan, A.; Moura, F.; Wadham, B.; Mccluney, S.; Parmar, C.; Shah, S.; Babar, M. S.; Goodrum, S.; Whitmore, H.; Balasubramaniam, D.; Jayasankar, B.; Kapoor, S.; Ramachandran, A.; Beech, N.; Chand, M.; Green, L.; Kiconco, H.; McEwen, R.; Pereca, J.; Arumugam, S.; Ibrahim, B.; Khan, K.; Gash, K.; Gourbault, L.; Maccabe, T. A.; Newton, C.; Baig, M.; Bates, H.; Dunne, N.; Khajuria, A.; Dr, Sarma; Shortland, T.; Tewari, N.; Akhtar, M. A.; Brunt, A.; McIntyre, J.; Milne, K.; Rashid, M. M.; Sgro, A.; Stewart, K. E.; Turnbull, A.; Gossedge, G.; O'Donnell, S.; Oldfield, F.; Gonzalez, Aguilar M.; Talukder, S.; Eskander, P.; Hanna, M.; Olivier, J.; Basnyat, P.; Davis, H.; Montauban, P.; Shrestha, A.; Magee, C.; Powell, S.; Flindall, I.; Hanson, A.; Mahendran, V.; Green, S.; Lim, M.; MacDonald, L.; Miu, V.; Onos, L.; Sheridan, K.; Young, R.; Alam, F.; Griffiths, O.; Houlden, C.; Kolli, V. S.; Lala, A. K.; Seymour, Z.; Consorti, E.; Gonzalez, R.; Kwan-Feinberg, R.; Liu, T.; Cooper, Z.; Hirji, S.; Mahvi, D.; Okafor, B.; Roxo, V.; Salim, A.; Loehrer, A.; Telma, K.; Bokenkamp, M.; Haynes, A. B.; Hill, C.; Leede, E.; McElhinney, K.; Olson, K. A.; Riley, C.; Bigelow, B.; Etchill, E. W.; Gabre-Kidan, A.; Jenny, H. E.; Kent, A.; Ladd, M. R.; Long, C.; Malapati, H.; Margalit, A.; Rapaport, S.; Rose, J.; Stevens, K.; Tsai, L.; Vervoort, D.; Yesantharao, P.; Klaristenfeld, D.; Huynh, K. T.; Kaafarani, H.; Naar, L.; Qadan, M.; Cha, D. E.; Gleeson, E.; Horn, C.; Sarpel, U.; Bhama, A.; Colling, K.; Najarian, M.; Azam, M.; Choudhry, A.; Marx, W.; Chokshi, R.; Glass, N.; Tsui, G.; Abel, M. K.; Boeck, M.; Chern, H.; Kornblith, L. Z.; Nunez-Garcia, B.; Ozgediz, D.; Sarin, A.; Varma, M. G.; Abbott, D.; Acher, A.; Aiken, T.; Barrett, J.; Foley, E.; Schwartz, P. B.; Zafar, S. N.; Hawkins, A. T.; Maiga, A.; Ruzgar, N. M.; Sion, M.; Ullrich, S.; Al-Naggar, H.; Al-Shehari, M.; Almassaudi, A.; Alsayadi, M.; Alsayadi, R.; Shream, S.; Uberruck, L.; Angelo, M.; Alga, A.; Celebi, F.; Colak, E.; Ogucu, H.; Arulanantham, A.; Bandara, G. B. K. D.; Jayarajah, U.; Ravindrakumar, S.; Rodrigo, V. S. D.; Collaborative, COVIDSurg; EuroSurg; European Soc Coloproctology, E. S. C. P.; Surg, Global Initiative Children's; GlobalSurg; GlobalPaedSurg; ItSURG; PTSurg; SpainSurg; SICCR, Italian Soc Colorectal Surg; ASiT, Assoc Surg Training; Irish Surg Res Collaborative, I. S. R. C.; Retrope, Transatlantic Australasian; Italian Soc Surg Oncology, S. I. C. O.
    Aim The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. Methods This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. Results Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6\% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5\% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7\% vs. 91.9\%, P = 0.032) and lower rates of emergency surgery (4.5\% vs. 22.5\%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95\% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95\% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. Conclusion One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease.
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    The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
    (NATL ACAD SCIENCES, 2022-01-01) Manry, Jeremy; Bastard, Paul; Gervais, Adrian; Le Voyer, Tom; Rosain, Jeremie; Philippot, Quentin; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martinez, Alba; Yang, Rui; Haljasmagi, Liis; Migaud, Melanie; Sarekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garcon, Pierre; Riviere, Jacques G.; Lagier, Jean-Christophe; Gentile, Stephanie; Rosen, Lindsey B.; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Megarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; Heath, James R.; Franco, Jose Luis; Anaya, Juan-Manuel; Sole-Violan, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; Delmonte, Ottavia M.; Zhang, Yu; Snow, Andrew L.; Holland, Steven M.; Biggs, Catherine M.; Moncada-Velez, Marcela; Arias, Andres Augusto; Lorenzo, Lazaro; Boucherit, Soraya; Anglicheau, Dany; Planas, Anna M.; Haerynck, Filomeen; Duvlis, Sotirija; Ozcelik, Tayfun; Keles, Sevgi; Bousfiha, Ahmed A.; El Bakkouri, Jalila; Ramirez-Santana, Carolina; Paul, Stephane; Pan-Hammarstrom, Qiang; Hammarstrom, Lennart; Dupont, Annabelle; Kurolap, Alina; Metz, Christine N.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; Barreiros, Lucila A.; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; van de Beek, Diederik; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; Tangye, Stuart G.; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Kann, Nelli Y.; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Reyes, Luis Felipe; Chauvineau-Grenier, Angelique; Venet, Fabienne; Monneret, Guillaume; Nussenzweig, Michel C.; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; Dyer, Adam H.; Kennelly, Sean; Bourkeh, Nollaig M.; Halwan, Rabih; Sharif-Askar, Fatemeh Saheb; Dorgham, Karim; Sallette, Jerome; Sedkaoui, Souad Mehlal; AlKhater, Suzan; Rigo-Bonnin, Raul; Morandeira, Francisco; Roussel, Lucie; Vinh, Donald C.; Erikstrup, Christian; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; Spaan, Andras N.; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; Lifton, Richard P.; Mane, Shrikant; Anderson, Mark S.; Boisson, Bertrand; Beziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Part; Mogensen, Trine H.; Rowen, Lee; Mond, James; Debette, Stephanie; de Lamballerie, Xavier; Burdet, Charles; Bouadma, Lila; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; Gregersen, Peter K.; Piemonti, Lorenzo; Rodriguez-Gallego, Carlos; D Notarangelo, Luigi; Su, Helen C.; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; Rice, Charles M.; Tiberghien, Pierre; Zhang, Qian; Casanova, Jean-Laurent; Abel, Laurent; Cobat, Aurelie; Lab, H. G. I. D.; Clinicians, C. O. V. I. D.; Clinicians, C. O. V. I. D.-S. T. O. R. M.; Grp, N.I.A.I.D. Immune Response C. O. V. I. D.; Grp, N. H.-C.O.V.A.I.R. Study; Danish, C. H. G. E.; Study, Danish Blood Donor; Hosp, St Jamess; Grp, French C.O.V.I.D. Cohort Study; COVID-Grp, Imagine; Consortium, Milieu Interieur; Cohort, CoV-Contact; Biobank, Amsterdam U.M.C. Covid-19; Effort, C.O.V.I.D. Human Genetic; Grp, C. P.-C. O. V. I. D.-19; Cohort, C. O. N. S. T. A. N. C. E. S.; Study, 3C.-Dijon; Hlth-Care, Cerba; Grp, Etab Francais Sang Study
    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-alpha, IFN-omega, and/or IFN-beta are found in similar to 20\% of deceased patients across age groups, and in similar to 1\% of individuals aged <70 y and in >4\% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-alpha 2 or IFN-omega, the RRDs were 17.0 (95\% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and >= 70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17\% (0.12 to 0.31) for individuals <40 y old to 26.7\% (20.3 to 35.2) for those >= 80 y old for autoantibodies neutralizing IFN-alpha 2 or IFN-omega, and from 0.84\% (0.31 to 8.28) to 40.5\% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-alpha 2 and IFN-omega. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
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    Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
    (SPRINGER, 2022-01-01) Akin, Ilke Mungan; Kanburoglu, Mehmet Kenan; Tayman, Cuneyt; Oncel, Mehmet Yekta; Imdadoglu, Timucin; Dilek, Mustafa; Yaman, Akan; Narter, Fatma; Er, Ilkay; Kahveci, Hasan; Erdeve, Omer; Koc, Esin; Grp, Neo-Covid Study
    The literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2\%), followed by feeding intolerance (25.6\%), and cough (21.6\%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7\%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio {[}OR]: 9.52, 95\% confidence interval {[}CI]: 4.17-21.71), tachypnea (OR: 26.5, 95\% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95\% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64\% and specificity of 73\%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.
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    Increased Severe Cases and New-Onset Type 1 Diabetes Among Children Presenting With Diabetic Ketoacidosis During First Year of COVID-19 Pandemic in Turkey
    (FRONTIERS MEDIA SA, 2022-01-01) Kiral, Eylem; Kirel, Birgul; Havan, Merve; Keskin, Mehmet; Karaoglan, Murat; Yildirim, Ahmet; Kangin, Murat; Talay, Mehmet Nur; Urun, Tuba; Altug, Umit; Kesici, Selman; Tufan, Erennur; Kacmaz, Ebru; Bozan, Gurkan; Azapagasi, Ebru; Uysal Yazici, Mutlu; Ozturk, Zeynelabidin; Yesilbas, Osman; Karaguzel, Gulay; Kaya, Gulay; Barlas, Ulkem; Duyu, Muhterem; Boyraz, Merve; Sevketoglu, Esra; Akcay, Nihal; Hancili, Suna; Guven, Ayla; Dursun, Oguz; Tekerek, Nazan Ulgen; Ozcifci, Gokcen; Yazici, Pinar; Turanli, Eda; Kendirli, Tanil; Kahveci, Fevzi; Yetimakman, Ayse Filiz; Citak, Agop; Sik, Guntulu; Bingol, Ibrahim; Aygun, Fatih; Durak, Cansu; Yilmaz, Resul; Bugrul, Fuat; Sari, Yusuf; Tekguc, Hakan; Albayrak, Hatice; Yener, Nazik; Agin, Hasan; Soydan, Ekin; Yildizdas, Dincer; Dilek, Semine Ozdemir; Yalindag, Nilufer; Incekoy-Girgin, Feyza; Alacakir, Nuri; Tutunculer, Filiz; Arslanaoglu, Mehmet Ozgur; Aydin, Can; Bilgin, Muzaffer; Simsek, Enver; Dinleyici, Ener Cagri
    IntroductionThere have been some significant changes regarding healthcare utilization during the COVID-19 pandemic. Majority of the reports about the impact of the COVID-19 pandemic on diabetes care are from the first wave of the pandemic. We aim to evaluate the potential effects of the COVID-19 pandemic on the severity of diabetic ketoacidosis (DKA) and new onset Type 1 diabetes presenting with DKA, and also evaluate children with DKA and acute COVID-19 infection. MethodsThis is a retrospective multi-center study among 997 children and adolescents with type 1 diabetes who were admitted with DKA to 27 pediatric intensive care units in Turkey between the first year of pandemic and pre-pandemic year. ResultsThe percentage of children with new-onset Type 1 diabetes presenting with DKA was higher during the COVID-19 pandemic (p < 0.0001). The incidence of severe DKA was also higher during the COVID-19 pandemic (p < 0.0001) and also higher among children with new onset Type 1 diabetes (p < 0.0001). HbA1c levels, duration of insulin infusion, and length of PICU stay were significantly higher/longer during the pandemic period. Eleven patients tested positive for SARS-CoV-2, eight were positive for new onset Type 1 diabetes, and nine tested positive for severe DKA at admission. DiscussionThe frequency of new onset of Type 1 diabetes and severe cases among children with DKA during the first year of the COVID-19 pandemic. Furthermore, the cause of the increased severe presentation might be related to restrictions related to the pandemic
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    International Association for the Study of Lung Cancer Study of the Impact of Coronavirus Disease 2019 on International Lung Cancer Clinical Trials
    (ELSEVIER SCIENCE INC, 2022-01-01) Smeltzer, Matthew P.; Scagliotti V, Giorgio; Wakelee, Heather A.; Mitsudomi, Tetsuya; Roy, Upal Basu; Clark, Russell C.; Arndt, Renee; Pruett, Clayton D.; Kelly, Karen L.; Ujhazy, Peter; Johnson, Melissa L.; Eralp, Yesim; Barrios, Carlos H.; Barlesi, Fabrice; Hirsch, Fred R.; Bunn, Paul A.; Coronavi, Int Assoc Study Lung Canc; Comm, Clinical Trials Steering
    Introduction: To evaluate the effects of the global coronavirus disease 2019 (COVID-19) pandemic on lung cancer trials, we surveyed investigators and collected aggregate enrollment data for lung cancer trials across the world before and during the pandemic. Methods: A Data Collection Survey collected aggregate monthly enrollment numbers from 294 global lung cancer trials for 2019 to 2020. A 64-question Action Survey evaluated the impact of COVID-19 on clinical trials and identified mitigation strategies implemented. Results: Clinical trial enrollment declined from 2019 to 2020 by 14\% globally. Most reductions in enrollment occurred in April to June where we found significant decreases in individual site enrollment (p = 0.0309). Enrollment was not significantly different in October 2019 to December of 2019 versus 2020 (p = 0.25). The most frequent challenges identified by the Action Survey (N = 172) were fewer eligible patients (63\%), decrease in protocol compliance (56\%), and suspension of trials (54\%). Patient-specific challenges included access to trial site (49\%), ability to travel (54\%), and willingness to visit the site (59\%). The most frequent mitigation strategies included modified monitoring requirements (47\%), telehealth visits (45\%), modified required visits (25\%), mailorder medications (25\%), and laboratory (27\%) and radiology (21\%) tests at nonstudy facilities. Sites that felt the most effective mitigation strategies were telehealth visits (85\%), remote patient-reported symptom collection (85\%), off-site procedures (85\%), and remote consenting (89\%).Conclusions: The COVID-19 pandemic created many challenges for lung cancer clinical trials conduct and enrollment. Mitigation strategies were used and, although the pandemic worsened, trial enrollment improved. A more flexible approach may improve enrollment and access to clinical trials, even beyond the pandemic.(c) 2022 Published by Elsevier Inc. on behalf of International Association for the Study of Lung Cancer.
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    Efficacy and safety profile of COVID-19 vaccine in cancer patients: a prospective, multicenter cohort study
    (FUTURE MEDICINE LTD, 2022-01-01) Yasin, Ayse Irem; Aydin, Sabin Goktas; Sumbul, Bilge; Koral, Lokman; Simsek, Melih; Geredeli, Caglayan; Ozturk, Akin; Perkin, Perihan; Demirtas, Derya; Erdemoglu, Engin; Hacibekiroglu, Ilhan; Cakir, Emre; Tanrikulu, Eda; Coban, Ezgi; Ozcelik, Melike; Celik, Sinemis; Teker, Fatih; Aksoy, Asude; Firat, Sedat T.; Tekin, Omer; Kalkan, Ziya; Turken, Orhan; Oven, Bala B.; Dane, Faysal; Bilici, Ahmet; Isikdogan, Abdurrahman; Seker, Mesut; Turk, Haci M.; Gumus, Mahmut
    Aim: To compare the seropositivity rate of cancer patients with non-cancer controls after inactive SARS-CoV-2 vaccination (CoronaVac) and evaluate the factors affecting seropositivity. Method: Spike IgG antibodies against SARS-CoV-2 were measured in blood samples of 776 cancer patients and 715 non-cancer volunteers. An IgG level >= 50 AU/ml is accepted as seropositive. Results: The seropositivity rate was 85.2\% in the patient group and 97.5\% in the control group. The seropositivity rate and antibody levels were significantly lower in the patient group (p < 0.001). Age and chemotherapy were associated with lower seropositivity in cancer patients (p < 0.001). Conclusion: This study highlighted the efficacy and safety of the inactivated vaccine in cancer patients. Clinical Trials Registration: ClinicalTrials.gov) Plain language summary Cancer patients are at high risk for infection with SARS-CoV-2 and of developing the associated disease, COVID-19, which therefore puts them in the priority group for vaccination. This study evaluated the efficacy and safety of CoronaVac, an inactivated virus vaccine, in cancer patients. The immune response rate, defined as seropositivity, was 85.2\% in the cancer patient group and 97.5\% in the control group. The levels of antibodies, which are blood markers of immune response to the vaccine, were also significantly lower in the patient group, especially in those older than 60 years and receiving chemotherapy. These results highlight the importance of determining the effective vaccine type and dose in cancer patients to protect them from COVID-19 without disrupting their cancer treatment.
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    Allergic diseases and immunodeficiencies in children, lessons learnt from COVID-19 pandemic by 2022: A statement from the EAACI-section on pediatrics
    (WILEY, 2022-01-01) Munblit, Daniel; Greenhawt, Matthew; Brough, Helen A.; Pushkareva, Anna; Karimova, Diana; Demidova, Anastasia; Warner, John O.; Kalayci, Omer; Sediva, Anna; Untersmayr, Eva; Rodriguez del Rio, Pablo; Vazquez-Ortiz, Marta; Arasi, Stefania; Alvaro-Lozano, Montserrat; Tsabouri, Sophia; Galli, Elena; Beken, Burcin; Eigenmann, Philippe A.
    By the April 12, 2022, the COVID-19 pandemic had resulted in over half a billion people being infected worldwide. There have been 6.1 million deaths directly due to the infection, but the pandemic has had many more short- and long-term pervasive effects on the physical and mental health of the population. Allergic diseases are among the most prevalent noncommunicable chronic diseases in the pediatric population, and health-care professionals and researchers were seeking answers since the beginning of pandemic. Children are at lower risk of developing severe COVID-19 or dying from infection. Allergic diseases are not associated with a higher COVID-19 severity and mortality, apart from severe/poorly controlled asthma. The pandemic disrupted routine health care, but many mitigation strategies, including but not limited to telemedicine, were successfully implemented to continue delivery of high-standard care. Although children faced a multitude of pandemic-related issues, allergic conditions were effectively treated remotely while reduction in air pollution and lack of contact with outdoor allergens resulted in improvement, particularly respiratory allergies. There is no evidence to recommend substantial changes to usual management modalities of allergic conditions in children, including allergen immunotherapy and use of biologicals. Allergic children are not at greater risk of multisystem inflammatory syndrome development, but some associations with Long COVID were reported, although the data are limited, and further research is needed. This statement of the EAACI Section on Pediatrics provides recommendations based on the lessons learnt from the pandemic, as available evidence.
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    Comparison of a novel antigen detection test with reverse transcription polymerase chain reaction assay for laboratory diagnosis of SARS-CoV-2 infection
    (SPRINGER HEIDELBERG, 2022-01-01) Cirit, Osman Sezer; Mutlu, Esvet; Sancak, Banu; Kocagoz, Tanil; Can, Ozge; Cicek, Candan; Sayiner, Ayca Arzu; Appak, Ozgur; Uyar, Neval Yurttutan; Kulah, Canan; Cicek, Aysegul Copur; Ozgumus, Osman Birol; Altintop, Yasemin Ay; Saatci, Esma; Karsligil, Tekin; Zer, Yasemin; Ozen, Nevgun Sepin; Cekin, Yesim; Karahan, Zeynep Ceren; Evren, Ebru; Karakoc, Ayse Esra; Orhan, Sultan Gulbahce; Mutlu, Derya; Bozdemir, Tugba; Cayci, Yeliz Tanriverdi; Cinar, Canberk; Tasbakan, Meltem; Mert, Merve; Cinar, Ece; Kutsoylu, Oya Ozlem Eren; Kocagoz, Sesin; Erturk, Ayse; Celik, Ilhami; Mete, Ayse Ozlem; Eneyli, Muge Gunalp; Akdemir, Irem; Karakok, Taliha; Inan, Dilara; Atilla, Aynur; Taflan, Sevket Onur; Yoruk, Kagan Etka
    Molecular diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time reverse transcription polymerase chain reaction (RT-PCR) in respiratory specimens is considered the gold standard method. This method is highly sensitive and specific but it has some limitations such as being expensive and requiring special laboratory equipment and skilled personnel. RapidFor (TM) Antigen Rapid Test Kit is a commercially available Ag-RDT which is produced in Turkey and designed to detect the nucleocapsid antigen of SARS-CoV-2 in nasopharyngeal swab samples. The aim of this study was to evaluate the performance of this novel SARS-CoV-2 antigen detection considering the RT-PCR method as the gold standard. Four hundred forty-four nasopharyngeal swab samples which were collected from the patients who met clinical criteria of COVID-19 from ten centers in Turkey between September 2020 and February 2021 were included in the study. All the nasopharyngeal swab samples were tested for SARS-CoV-2 RNA using commercial RT-PCR kits (Bioeksen and A1 Lifesciences, Istanbul, Turkey) according to the manufacturer's instructions. Viral loads were assessed according to the cycle threshold (Ct) values. RapidFor (TM) SARS-CoV-2 antigen test (Vitrosens Biotechnology, Istanbul, Turkey) was used to investigate the presence of SARS-CoV-2 antigen in all samples following the manufacturer's instructions. Out of 444 nasopharyngeal swab samples tested, 346 (77.9\%) were positive and 98 (22.1\%) were negative for SARS-CoV-2 RNA by RTPCR. Overall sensitivity of the RapidFor (TM). Antigen Rapid Test Kit was 80.3\% whereas specificity was found to be 87.8\%. Positivity rate of rapid antigen test in samples with Ct values over 25 and below 30 was 82.7\%, while it increased to 95.7\% in samples 20 <= Ct < 25 and reached 100\% in samples with Ct values below 20. RapidFor (TM) SARS-CoV-2 Ag test might be a good choice in the screening of symptomatic and asymptomatic patients and their contacts for taking isolation measures early, with advantages over RT-PCR as being rapid, easy and being applicable in every laboratory and even at point of care.
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    COVID-19 in pediatric patients undergoing chronic dialysis and kidney transplantation
    (SPRINGER, 2022-01-01) Canpolat, Nur; Yildirim, Zeynep Yuruk; Yildiz, Nurdan; Tasdemir, Mehmet; Goknar, Nilufer; Evrengul, Havva; Gulmez, Ruveyda; Aksu, Bagdagul; Dursun, Hasan; Ozcelik, Gul; Yavascan, Onder; Cicek, Rumeysa Yasemin; Tulpar, Sebahat; Hacihamdioglu, Duygu Ovunc; Nayir, Ahmet; Alpay, Harika
    The study aims to present the incidence of COVID-19 in pediatric patients undergoing renal replacement therapy (RRT) and to compare the severity and outcomes of the disease between the dialysis and kidney transplant (KTx) groups. This multicenter observational study was conducted between 1 April and 31 December 2020 in Istanbul. Members of the Istanbul branch of the Turkish Pediatric Nephrology Association were asked to report all confirmed cases of COVID-19 who were on RRT, as well as the number of prevalent RRT patients under the age of 20. A total of 46 confirmed cases of COVID-19 were reported from 12 centers, of which 17 were dialysis patients, and 29 were KTx recipients. Thus, the incidence rate of COVID-19 was 9.3\% among dialysis patients and 9.2\% among KTx recipients over a 9-month period in Istanbul. Twelve KTx recipients and three dialysis patients were asymptomatic (p = 0.12). Most of the symptomatic patients in both the dialysis and KTx groups had a mild respiratory illness. Only two patients, one in each group, experienced a severe disease course, and only one hemodialysis patient had a critical illness that required mechanical ventilation. In the entire cohort, one hemodialysis patient with multiple comorbidities died. Conclusion: While most cases are asymptomatic or have a mild disease course, pediatric patients undergoing dialysis and a kidney transplant are at increased risk for COVID-19. What is Known: In adult population, both dialysis patients and kidney transplant recipients are at increased risk for severe illness of COVID-19 and have higher mortality rate. Children with kidney transplantation are not at increased risk for COVID-19 and most have mild disease course. Data on children on dialysis are scarce. What is New: Pediatric patients undergoing dialysis and kidney transplantation have an increased risk for COVID-19. Most patients undergoing renal replacement therapy either on dialysis or transplanted develop asymptomatic or mild COVID-19 disease with a favorable outcome.
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    Attitudes of patients with spondylarthritis or rheumatoid arthritis regarding biological treatment during COVID-19 pandemic: A multi-center, phone-based, cross-sectional study
    (TURKISH LEAGUE AGAINST RHEUMATISM, 2021-01-01) Zateri, Coskun; Birtane, Murat; Aktas, Ilknur; Sarikaya, Selda; Rezvani, Aylin; Altan, Lale; Dursun, Nigar; Dursun, Erbil; Tastekin, Nurettin; Celiker, Reyhan; Ozdolap, Senay; Akgun, Kenan
    Objectives: In this study, we aimed to investigate the medical treatment attitudes of patients with spondylarthritis or rheumatoid arthritis (RA) who were using biological drugs during the novel coronavirus-2019 (COVID-19) pandemic. Patients and methods: In this multi-center, cross-sectional study, a total of 277 patients (178 males, 99 females