Near infrared-absorbing self-encapsulated phthalocyanine-cored polycaprolactone star polymeric nanoparticles
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Date
Journal Title
Journal ISSN
Volume Title
dc.identifier.issn
1088-4246
1099-1409
1099-1409
dc.identifier.doi
10.1142/S1088424624500020
dc.identifier.other
dc.description.volume
28
dc.description.issue
2
Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI
10.1142/S1088424624500020
10.1142/S1088424624500020
10.1142/S1088424624500020
Abstract
An octahydroxylated photosensitizing Zn phthalocyanine has been used as an initiator in ring-opening polymerization of epsilon-caprolactone. Three different phthalocyanine-core star polymers have been obtained, with each arm functionalized with either 20, 30, or 40 units. To benefit from the absorption of these polymers in the first near-infrared (NIR) phototherapeutic window, the phthalocyanine cores have been self-encapsulated into their polycaprolactone arms to yield biocompatible star polymeric nanoparticles exhibiting a remarkable absorption centered at 782 nm and an excellent logarithmic extinction coefficient value in water.
Description
Keywords
Phthalocyanine , Polycaprolactone , Biocompatible materials , Near-infrared (NIR) absorption , RING-OPENING POLYMERIZATION , PHOTODYNAMIC THERAPY , PHOTOPHYSICAL PROPERTIES , CELLULAR UPTAKE , DRUG-DELIVERY , PHOTOSENSITIZERS , POLY(EPSILON-CAPROLACTONE) , COMPLEXES , SUBSTITUENTS , FLUORESCENCE , Chemistry, Multidisciplinary , Chemistry