Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study
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Date
Journal Title
Journal ISSN
Volume Title
dc.identifier.issn
0735-7907
1532-4192
1532-4192
dc.identifier.doi
10.1080/07357907.2025.2595536
dc.identifier.other
dc.description.volume
44
dc.description.issue
2
Publisher
TAYLOR & FRANCIS INC
DOI
10.1080/07357907.2025.2595536
10.1080/07357907.2025.2595536
10.1080/07357907.2025.2595536
Abstract
The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR
Description
Keywords
Disease-free survival , Local recurrence , Local advanced rectal cancer , Neoadjuvant chemoradiation , Pathological complete response , Overall survival , Surgical outcome , DIFFUSION-WEIGHTED MRI , PHASE-III TRIAL , PREOPERATIVE CHEMORADIOTHERAPY , PROGNOSTIC-SIGNIFICANCE , RADIOTHERAPY , SURGERY , RADIOCHEMOTHERAPY , CHEMORADIATION , CAPECITABINE , REGRESSION , Oncology