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Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study

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dc.contributor.authorUysal, Mukremin
dc.contributor.authorSaglam, Sezer
dc.contributor.authorBeypinar, Ismail
dc.contributor.authorSaglam, Esra Kaytan
dc.contributor.authorMammadov, Elkhan
dc.contributor.authorOcak, Birol
dc.contributor.authorAybi, Ozge
dc.contributor.authorArikan, Rukiye
dc.contributor.authorErgen, Sefika Arzu
dc.contributor.authorGursoy, Pinar
dc.contributor.authorSakin, Abdullah
dc.contributor.authorKaya, Vildan
dc.contributor.authorOzden, Ercan
dc.contributor.authorEren, Tulay
dc.contributor.authorDemiray, Atike Gokcen
dc.contributor.authorOyman, Abdilkerim
dc.contributor.authorTatli, Ali Murat
dc.contributor.authorTurk, Haci Mehmet
dc.contributor.authorGulmez, Ahmet
dc.contributor.authorDemir, Atakan
dc.contributor.authorAlan, Ozkan
dc.contributor.authorSakalar, Teoman
dc.contributor.authorSen, Erdem
dc.contributor.authorUcar, Gokhan
dc.contributor.authorKilickap, Saadettin
dc.contributor.authorBilici, Ahmet
dc.contributor.authorOksuz, Didem Colpan
dc.contributor.authorKarabulut, Bulent
dc.date.accessioned2026-11-05T11:02:57Z
dc.date.issued2026
dc.description.abstractThe goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR
dc.description.issue2
dc.description.pages127-135
dc.description.volume44
dc.identifier.doi10.1080/07357907.2025.2595536
dc.identifier.issn0735-7907
dc.identifier.issn1532-4192
dc.identifier.urihttps://doi.org/10.1080/07357907.2025.2595536
dc.identifier.urihttps://openaccess.acibadem.edu.tr/handle/11443/10991
dc.identifier.wosWOS:001631349200001
dc.language.isoen
dc.publisherTAYLOR & FRANCIS INC
dc.relation.hasversion10.1080/07357907.2025.2595536
dc.relation.ispartofCANCER INVESTIGATION
dc.subjectDisease-free survival
dc.subjectLocal recurrence
dc.subjectLocal advanced rectal cancer
dc.subjectNeoadjuvant chemoradiation
dc.subjectPathological complete response
dc.subjectOverall survival
dc.subjectSurgical outcome
dc.subjectDIFFUSION-WEIGHTED MRI
dc.subjectPHASE-III TRIAL
dc.subjectPREOPERATIVE CHEMORADIOTHERAPY
dc.subjectPROGNOSTIC-SIGNIFICANCE
dc.subjectRADIOTHERAPY
dc.subjectSURGERY
dc.subjectRADIOCHEMOTHERAPY
dc.subjectCHEMORADIATION
dc.subjectCAPECITABINE
dc.subjectREGRESSION
dc.subjectOncology
dc.titleLong-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study
dc.typeArticle
oaire.citation.editionScience Citation Index Expanded (SCI-EXPANDED)
oaire.citation.endPage135
oaire.citation.issue2
oaire.citation.startPage127
oaire.citation.volume44
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person.identifier.ridAAN-1107-2020
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person.identifier.ridAAV-5044-2020
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person.identifier.ridAEC-2238-2022
person.identifier.ridABI-8218-2020
person.identifier.ridD-9111-2018
person.identifier.ridOTH-8852-2025

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