Morphometric Analysis of the Effects of Manuka Honey on Vasospastic Femoral Arteries in Rats: An Experimental Study
dc.contributor.author | Tanriverdi, Osman | |
dc.contributor.author | Yilmaz, Ilhan | |
dc.contributor.author | Erdogan, Uzay | |
dc.contributor.author | Gunaldi, Omur | |
dc.contributor.author | Gungor, Abuzer | |
dc.contributor.author | Adilay, Huseyin Utku | |
dc.contributor.author | Arslanhan, Ayca | |
dc.contributor.author | Tugcu, Bekir | |
dc.date.accessioned | 2023-02-21T12:38:28Z | |
dc.date.available | 2023-02-21T12:38:28Z | |
dc.date.issued | 2018-01-01 | |
dc.description.abstract | Objectives: The aim of this study was to determine if Manuka honey, a potent anti-inflammatory and antioxidant agent, had any effect on the development of vasospasm in an experimental subarachnoidal hemorrhage model constructed in rat femoral arteries. Methods: Twenty-four Wistar Albino strain rats were divided into 3 groups: Group 1 was the control group (n=8), Group 2 was the vasospasm group (n=8), and group 3 was the treatment group (n=8). The wall thickness (W) of the femoral arteries and the luminal diameter (L) were measured using morphometric methods. The data were analyzed with statistical software. The Mann-Whitney U-test was used to compare independent groups and Bonferroni post hoc analysis was used for multiple comparison tests. Significance for all of the results was established at p<0.05. Results: A statistically significant intergroup difference was detected in the mean L and W (p<0.001, p=0.001, respectively). The mean L value in Group 2 was statistically significantly less than that of Groups 1 and 3, while the mean W value was significantly greater (p<0.001 for all). However, no statistically significant difference was detected between Groups 1 and 3 with respect to the mean L and W values (p=0.064, p=0.954, respectively). Conclusion: Manuka honey exerts an antioxidant and anti-inflammatory effect via inhibition of inflammatory cytokines, including plasma tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-6, and the lipid peroxidation level. This study statistically demonstrated that the anti-inflammatory and antioxidant properties of Manuka honey successfully inhibited the development of vasospasm in an experimentally induced vasospasm model in the femoral arteries of rats. | |
dc.description.issue | 4 | |
dc.description.pages | 268-273 | |
dc.description.volume | 52 | |
dc.identifier.doi | 10.14744/SEMB.2018.35761 | |
dc.identifier.uri | https://hdl.handle.net/11443/2387 | |
dc.identifier.uri | http://dx.doi.org/10.14744/SEMB.2018.35761 | |
dc.identifier.wos | WOS:000454998800006 | |
dc.publisher | YERKURE TANITIM YAYINCILIK HIZMETLERI AS | |
dc.relation.ispartof | MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL | |
dc.subject | Antioxidant | |
dc.subject | anti-inflammatory | |
dc.subject | manuka honey | |
dc.subject | subarachnoidal hemorrhage | |
dc.subject | vasospasm | |
dc.title | Morphometric Analysis of the Effects of Manuka Honey on Vasospastic Femoral Arteries in Rats: An Experimental Study | |
dc.type | Article |