Morphometric Analysis of the Effects of Manuka Honey on Vasospastic Femoral Arteries in Rats: An Experimental Study

dc.contributor.authorTanriverdi, Osman
dc.contributor.authorYilmaz, Ilhan
dc.contributor.authorErdogan, Uzay
dc.contributor.authorGunaldi, Omur
dc.contributor.authorGungor, Abuzer
dc.contributor.authorAdilay, Huseyin Utku
dc.contributor.authorArslanhan, Ayca
dc.contributor.authorTugcu, Bekir
dc.date.accessioned2023-02-21T12:38:28Z
dc.date.available2023-02-21T12:38:28Z
dc.date.issued2018-01-01
dc.description.abstractObjectives: The aim of this study was to determine if Manuka honey, a potent anti-inflammatory and antioxidant agent, had any effect on the development of vasospasm in an experimental subarachnoidal hemorrhage model constructed in rat femoral arteries. Methods: Twenty-four Wistar Albino strain rats were divided into 3 groups: Group 1 was the control group (n=8), Group 2 was the vasospasm group (n=8), and group 3 was the treatment group (n=8). The wall thickness (W) of the femoral arteries and the luminal diameter (L) were measured using morphometric methods. The data were analyzed with statistical software. The Mann-Whitney U-test was used to compare independent groups and Bonferroni post hoc analysis was used for multiple comparison tests. Significance for all of the results was established at p<0.05. Results: A statistically significant intergroup difference was detected in the mean L and W (p<0.001, p=0.001, respectively). The mean L value in Group 2 was statistically significantly less than that of Groups 1 and 3, while the mean W value was significantly greater (p<0.001 for all). However, no statistically significant difference was detected between Groups 1 and 3 with respect to the mean L and W values (p=0.064, p=0.954, respectively). Conclusion: Manuka honey exerts an antioxidant and anti-inflammatory effect via inhibition of inflammatory cytokines, including plasma tumor necrosis factor alpha, interleukin (IL)-1 beta, IL-6, and the lipid peroxidation level. This study statistically demonstrated that the anti-inflammatory and antioxidant properties of Manuka honey successfully inhibited the development of vasospasm in an experimentally induced vasospasm model in the femoral arteries of rats.
dc.description.issue4
dc.description.pages268-273
dc.description.volume52
dc.identifier.doi10.14744/SEMB.2018.35761
dc.identifier.urihttps://hdl.handle.net/11443/2387
dc.identifier.urihttp://dx.doi.org/10.14744/SEMB.2018.35761
dc.identifier.wosWOS:000454998800006
dc.publisherYERKURE TANITIM YAYINCILIK HIZMETLERI AS
dc.relation.ispartofMEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
dc.subjectAntioxidant
dc.subjectanti-inflammatory
dc.subjectmanuka honey
dc.subjectsubarachnoidal hemorrhage
dc.subjectvasospasm
dc.titleMorphometric Analysis of the Effects of Manuka Honey on Vasospastic Femoral Arteries in Rats: An Experimental Study
dc.typeArticle

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