Correlation of Copeptin with N-terminal pro-brain natriuretic peptide in predicting the severity and prognosis of acute pulmonary embolism Copeptin in acute pulmonary embolism
dc.contributor.author | Yavasi, Ozcan | |
dc.contributor.author | Kayayurt, Kamil | |
dc.contributor.author | Bilir, Ozlem | |
dc.contributor.author | Ersunan, Gokhan | |
dc.contributor.author | Ozyurt, Songul | |
dc.contributor.author | Kirbas, Aynur | |
dc.contributor.author | Ugras, Erhan | |
dc.date.accessioned | 2023-02-21T12:34:47Z | |
dc.date.available | 2023-02-21T12:34:47Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | Aim: In this study, we aimed to compare copeptin with N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I for predicting severity and 3-month mortality in acute PE in the emergency department (ED). Material and Methods: All ED patients older than 18 years who were confirmed to have acute PE within six hours of diagnostic work-up were enrolled and prospectively screened. Risk stratification was made according to the 2014 European Society of Cardiology guideline on PE. The study endpoints were defined as 3-month mortality, presence of non-low risk PE, and presence of right ventricular (RV) dysfunction. The Mann-Whitney Ll test was used for the comparison of medians. Receiver operating characteristic curves were generated and the area under the curve (AUC) was calculated to determine the best cut-off values of copeptin and NT-proBNP. A P value < 0.05 was considered statistically significant. Results: The study enrolled 82 patients. Twelve patients who died during 3 months had higher concentrations of NT-proBNP and copeptin, but not troponin I. The AUCs of NT-proBNP and copeptin to accurately predict the 3-month mortality were 0.73 +/- 0.09 (95\% CI, 0.62 - 0.82 | |
dc.description.abstract | p = 0.013) and 0.78 +/- 0.09 (95\% CI, 0.68 - 0.86 | |
dc.description.abstract | p = 0.003), respectively. Low-risk patients, according to Pulmonary Embolism Severity Index, had lower concentrations of copeptin and NT-proBNP compared to intermediate-high risk patients. All three markers discriminated the presence of RV dysfunction truly. Discussion: Copeptin correlates with NT-proBNP and appears beneficial for early risk stratification of acute pulmonary embolism in the ED. | |
dc.description.issue | S4 | |
dc.description.issue | SEP 15 | |
dc.description.pages | 472-477 | |
dc.description.volume | 12 | |
dc.identifier.doi | 10.4328/ACAM.20645 | |
dc.identifier.uri | https://hdl.handle.net/11443/1812 | |
dc.identifier.uri | http://dx.doi.org/10.4328/ACAM.20645 | |
dc.identifier.wos | WOS:000731638200023 | |
dc.publisher | BAYRAKOL MEDICAL PUBLISHER | |
dc.relation.ispartof | ANNALS OF CLINICAL AND ANALYTICAL MEDICINE | |
dc.subject | Acute Pulmonary Embolism | |
dc.subject | Copeptin | |
dc.subject | Emergency Department | |
dc.subject | N-Terminal Probrain Natriuretic Peptide | |
dc.subject | Troponin | |
dc.title | Correlation of Copeptin with N-terminal pro-brain natriuretic peptide in predicting the severity and prognosis of acute pulmonary embolism Copeptin in acute pulmonary embolism | |
dc.type | Article |