Mid-term implant survival, functional and radiological results and mechanical complications of mega-prosthetic reconstruction around the knee with the PENTA (R) system

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dc.contributor.authorOzger, Harzem
dc.contributor.authorAlpan, Bugra
dc.contributor.authorSalduz, Ahmet
dc.contributor.authorGurkan, Volkan
dc.contributor.authorSungur, Mustafa
dc.contributor.authorValiyev, Natig
dc.contributor.authorEralp, Levent
dc.date.accessioned2023-02-21T12:37:24Z
dc.date.available2023-02-21T12:37:24Z
dc.date.issued2022-01-01
dc.description.abstractAim Mega-prosthetic reconstruction is the most common treatment method for massive osteoarticular defects caused by tumor resection around the knee. The new implant is a highly modular rotational-hinged megaprosthesis system with a distinct pentagonal stem geometry and variable implantation options. The aim of this study is to present the mid-term implant survival characteristics, functional and radiological results and mechanical complication profile of the new megaprosthesis. Methods One hundred and one mega-prosthetic knee reconstruction procedures in 90 patients (M/F: 51/39) utilizing the new implant system were retrospectively analyzed. In 68 patients, the megaprosthesis was used for primary reconstruction following tumor resection while it was used for revision of other implants in 22. The mean age was 28.5 (7-66) years and the mean follow-up was 59.2 (24-124) months. The most common primary pathology was osteosarcoma with 63-70\% patients, the most common anatomical site of involvement was the distal femur with 56-62\% patients. Results Henderson Type 2 failure (aseptic loosening) was seen in only 2-2.2\% patients while Type 3 (structural failure) was seen in 29-32.2\% Although the 5-year anchorage survival rate was 94.3\%, overall mechanical implant survival was 76.1\% at 5 years due to a relatively high failure rate in the first-generation hinge mechanism of the implant. The 5-year hinge survival rate demonstrated a significant improvement rate from 61.7\% to 87.2\% between the first and second generations of the implant (p = 0.027). The mean MSTS score was 24 out of 30 (14-29). The mean cumulative ISOLS radiographic score for index megaprosthesis operations was 19.7 (12-24), which corresponded to excellent outcome. Conclusion The new megaprosthesis system is a reliable choice for the reconstruction of tumor-related massive osteoarticular defects around the knee. Although long-term follow-up is necessary for a definitive evaluation of the implant's survival characteristics, midterm follow-up yields exceptional anchorage properties related to pentagonal stem geometry with very good functional outcomes.
dc.description.issue9
dc.description.issueSEP
dc.description.pages2323-2333
dc.description.volume142
dc.identifier.doi10.1007/s00402-021-04108-3
dc.identifier.urihttps://hdl.handle.net/11443/2241
dc.identifier.urihttp://dx.doi.org/10.1007/s00402-021-04108-3
dc.identifier.wosWOS:000686989600001
dc.publisherSPRINGER
dc.relation.ispartofARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
dc.subjectLimb salvage
dc.subjectBone neoplasms
dc.subjectSurgical oncology
dc.subjectKnee prosthesis
dc.subjectReconstructive surgical procedure
dc.subjectProsthesis failure
dc.subjectProsthesis survival
dc.subjectKnee joint
dc.titleMid-term implant survival, functional and radiological results and mechanical complications of mega-prosthetic reconstruction around the knee with the PENTA (R) system
dc.typeArticle
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