Clinical significance of plasma tryptophan, kynurenine, and kynurenine/tryptophan ratio in rheumatoid arthritis patients
Clinical significance of plasma tryptophan, kynurenine, and kynurenine/tryptophan ratio in rheumatoid arthritis patients
Tarih
2022-01-01
Yazarlar
Kor, Ahmet
Erten, Sukran
Yurt, Emine F.
Dogan, Ismail
Apaydin, Hakan
Aserdar, Muhittin
Bicer, Cemile
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
ELSEVIER
Dergi Adı
EGYPTIAN RHEUMATOLOGIST
Özet
Background: The catabolism of tryptophan (Trp) in the kynurenine (Kyn) pathway is thought to have a critical immunosuppressive effect.Aim of the work: To evaluate plasma Trp and metabolite levels to identify their diagnostic potential in rheumatoid arthritis (RA).Patients and methods: 50 RA patients and 41 control were included in this study. The Trp and Kyn were analyzed and the Kyn\textbackslash{}Trp ratio was calculated to estimate Indolamine 2,3 dioxygenase (IDO) enzyme activity involved in Trp degradation.Results: The 50 patients had a mean age of 58.5 +/- 10.6 years
37 females and 13 males, F:M 2.8:1 and median disease duration was 10.1 (7-16) years. Rheumatoid factor was positive in 64 \%. The median Trp value was significantly lower in RA (11120.7
3259-16352 ng/ml) compared to control (12372.3
7217-31,936 ng/ml) (p = 0.001). Kyn/Trp was significantly higher in RA (4.04
2.5-12.3) compared to con-trol (3.2
2.1-4.7) (p < 0.0001). The median Kyn value was higher in RA (451.02
264-1292 ng/ml) than in control (391.4
236-1494 ng/ml) (p = 0.04). Trp significantly inversely correlated with the morning stiff-ness (r =-0.32, p = 0.025), Kyn significantly correlated with the C-reactive protein (CRP) (r = 0.31, p = 0.028) and erythrocyte sedimentation rate (ESR) (r = 0.41, p = 0.003) and the Kyn/Trp ratio correlated with the morning stiffness, CRP and ESR (r = 0.26, p = 0.045
r = 0.32, p = 0.025 and r = 0.32, p = 0.024 respectively). Kyn/Trp, Kyn and Trp significantly predicted RA at a cut-off value of 4.72, 589.1 ng/ml and 9921.1 ng/ml (p < 0.0001, p = 0.04 and p = 0.001 respectively).Conclusion: Our study showed that there is a significant relationship between RA and Kyn and Trp levels and IDO enzyme activity.(c) 2022 THE AUTHORS. Publishing services by ELSEVIER B.V. on behalf of The Egyptian Society of Rheu-matic Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
37 females and 13 males, F:M 2.8:1 and median disease duration was 10.1 (7-16) years. Rheumatoid factor was positive in 64 \%. The median Trp value was significantly lower in RA (11120.7
3259-16352 ng/ml) compared to control (12372.3
7217-31,936 ng/ml) (p = 0.001). Kyn/Trp was significantly higher in RA (4.04
2.5-12.3) compared to con-trol (3.2
2.1-4.7) (p < 0.0001). The median Kyn value was higher in RA (451.02
264-1292 ng/ml) than in control (391.4
236-1494 ng/ml) (p = 0.04). Trp significantly inversely correlated with the morning stiff-ness (r =-0.32, p = 0.025), Kyn significantly correlated with the C-reactive protein (CRP) (r = 0.31, p = 0.028) and erythrocyte sedimentation rate (ESR) (r = 0.41, p = 0.003) and the Kyn/Trp ratio correlated with the morning stiffness, CRP and ESR (r = 0.26, p = 0.045
r = 0.32, p = 0.025 and r = 0.32, p = 0.024 respectively). Kyn/Trp, Kyn and Trp significantly predicted RA at a cut-off value of 4.72, 589.1 ng/ml and 9921.1 ng/ml (p < 0.0001, p = 0.04 and p = 0.001 respectively).Conclusion: Our study showed that there is a significant relationship between RA and Kyn and Trp levels and IDO enzyme activity.(c) 2022 THE AUTHORS. Publishing services by ELSEVIER B.V. on behalf of The Egyptian Society of Rheu-matic Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
Açıklama
Anahtar kelimeler
Rheumatoid arthritis, Tryptophan catabolism, IDO activity