Comparison of paracetamol and diclofenac prescribing preferences for adults in primary care

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dc.contributor.authorBayram, Dilara
dc.contributor.authorAydin, Volkan
dc.contributor.authorSanli, Abdullah
dc.contributor.authorAbanoz, Mustafa Naci
dc.contributor.authorSibic, Busra
dc.contributor.authorPala, Sedat
dc.contributor.authorAtac, Omer
dc.contributor.authorAkici, Ahmet
dc.date.accessioned2023-02-21T12:36:00Z
dc.date.available2023-02-21T12:36:00Z
dc.date.issued2021-01-01
dc.description.abstractIntroduction: The most frequently prescribed analgesic drugs in primary care centers in Turkey are diclofenac and paracetamol, respectively. In this study, we aimed to compare paracetamol-included prescriptions (PIP) and diclofenac-included prescriptions (DIP) generated for adult patients in primary care. Methods: In this cross-sectional study, PIPs (n = 280 488) and DIPs (n = 337 935) created for adults by systematic sampling among primary care physicians working in Istanbul in 2016 (n = 1431) were examined. The demographic characteristics, diagnoses, and additional drugs in PIPs and DIPs were compared. Results: Women constituted the majority in both groups (69.8\% and 67.9\%, respectively
dc.description.abstractP < 0.05), and mean age at PIP (52.6 +/- 18.8 years) was lower compared to DIP (56.3 +/- 16.1 years), (P < 0.05). In single-diagnosis prescriptions, 11 of the 15 most common diagnoses in PIP were respiratory tract infections (47.9\%)
dc.description.abstractthree pain-related diagnoses formed 4.6\% of all these prescriptions. In DIP, the number of pain-related diagnoses, mostly of musculoskeletal origin, was eight (28.5\%)
dc.description.abstractfour diagnoses (7.8\%) were upper respiratory tract infections. While hypertension was the third most common diagnosis in PIP (6.1\%), it was ranked first in DIP (8.0\%). The percentage of prescriptions with additional analgesic (14.0\% versus 18.3\%, P < 0.001), proton-pump inhibitor (13.8\% versus 18.4\%
dc.description.abstractP < 0.001), and antihypertensive (22.0\% versus 24.8\%, P < 0.001) was lower in PIP compared to DIP. However, the percentage of prescriptions with antibiotics (31.3\% versus 14.7\%, P < 0.001) was higher in PIP. Conclusion: Paracetamol appears to be preferred mostly in upper respiratory tract infections compared to the preference of diclofenac rather in painful/inflammatory musculoskeletal conditions. The presence of hypertension among the most commonly encountered diagnoses for these analgesic drugs points to challenges in establishing the diagnosing-treatment match and indicates potential irrational prescribing practice, especially for interactions.
dc.description.issueDEC 2
dc.description.volume22
dc.identifier.doi10.1017/S1463423621000797
dc.identifier.urihttps://hdl.handle.net/11443/2032
dc.identifier.urihttp://dx.doi.org/10.1017/S1463423621000797
dc.identifier.wosWOS:000724546200001
dc.publisherCAMBRIDGE UNIV PRESS
dc.relation.ispartofPRIMARY HEALTH CARE RESEARCH AND DEVELOPMENT
dc.subjectanalgesic
dc.subjectdiclofenac
dc.subjectpain
dc.subjectparacetamol
dc.subjectprescribing
dc.subjectprimary care
dc.titleComparison of paracetamol and diclofenac prescribing preferences for adults in primary care
dc.typeArticle
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