Epidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society

dc.contributor.authorAkin, Ilke Mungan
dc.contributor.authorKanburoglu, Mehmet Kenan
dc.contributor.authorTayman, Cuneyt
dc.contributor.authorOncel, Mehmet Yekta
dc.contributor.authorImdadoglu, Timucin
dc.contributor.authorDilek, Mustafa
dc.contributor.authorYaman, Akan
dc.contributor.authorNarter, Fatma
dc.contributor.authorEr, Ilkay
dc.contributor.authorKahveci, Hasan
dc.contributor.authorErdeve, Omer
dc.contributor.authorKoc, Esin
dc.contributor.authorGrp, Neo-Covid Study
dc.date.accessioned2023-02-21T12:42:57Z
dc.date.available2023-02-21T12:42:57Z
dc.date.issued2022-01-01
dc.description.abstractThe literature on neonates with SARS-CoV-2 is mainly concerned with perinatal cases, and scanty data are available about environmentally infected neonates. To fill knowledge gaps on the course and prognosis of neonatal cases, we analyzed 1-year data from the Turkish Neonatal Society in this prospective cohort study of neonates with postnatal transmission. Data from 44 neonatal intensive care units (NICUs), of neonates with positive RT-PCR results at days 5-28 of life, were extracted from the online registry system and analyzed. Of 176 cases, most were term infants with normal birth weight. Fever was the most common symptom (64.2\%), followed by feeding intolerance (25.6\%), and cough (21.6\%). The median length of hospitalization was 9 days, with approximately one quarter of infants receiving some type of ventilatory support. Myocarditis (5.7\%) was the most common complication during follow-up. Among the clinical findings, cough (odds ratio {[}OR]: 9.52, 95\% confidence interval {[}CI]: 4.17-21.71), tachypnea (OR: 26.5, 95\% CI: 9.59-73.19), and chest retractions (OR: 27.5, 95\% CI: 5.96-126.96) were associated with more severe clinical disease. Also, there were significant differences in the C-reactive protein level, prothrombin time (PT), partial thromboplastin time, international normalized ratio, and days in the NICU (p = 0.002, p = 0.012, p = 0.034, p = 0.008, and p < 0.001, respectively) between patients with mild-moderate and severe-critical presentations. A PT above 14 s was a significant predictor of severe/critical cases, with a sensitivity of 64\% and specificity of 73\%. Conclusions: Our data showed that late-onset COVID-19 infection in neonates who need hospitalization can be severe, showing associations with high rates of ventilatory support and myocarditis. Cough, tachypnea, and retractions on admission suggest a severe disease course.
dc.description.issue5
dc.description.issueMAY
dc.description.pages1933-1942
dc.description.volume181
dc.identifier.doi10.1007/s00431-021-04358-8
dc.identifier.urihttps://hdl.handle.net/11443/2862
dc.identifier.urihttp://dx.doi.org/10.1007/s00431-021-04358-8
dc.identifier.wosWOS:000745396400001
dc.publisherSPRINGER
dc.relation.ispartofEUROPEAN JOURNAL OF PEDIATRICS
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectNewborn
dc.subjectPostnatal
dc.titleEpidemiologic and clinical characteristics of neonates with late-onset COVID-19: 1-year data of Turkish Neonatal Society
dc.typeArticle

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