Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency
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Tarih
Yazarlar
Cakiroglu, Yigit
Saltik, Ayse
Yuceturk, Aysen
Karaosmanoglu, Ozge
Kopuk, Sule Yildirim
Scott Jr., Richard T.
Tiras, Bulent
Seli, Emre
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
ISSN
DOI No
10.18632/aging.103403
Diğer Tanımlayıcı No
Cilt
12
Sayı
11
JUN 15
JUN 15
Yayınevi
Özet
We aimed to determine whether intraovarian injection of autologous platelet rich plasma (PRP) improves response to ovarian stimulation and in vitro fertilization (IVF) outcome in women with primary ovarian insufficiency (PO1). Women (N=311
age 24-40) diagnosed with POI based on ESHRE criteria underwent intraovarian PRP injection. Markers of ovarian reserve, and IVF outcome parameters were followed. PRP treatment resulted in increased antral follicle count (AFC) and serum antimullerian hormone (AMH), while serum follicle stimulating hormone (FSH) did not change significantly. After PRP injection, 23 women (7.4\%) conceived spontaneously, 201 (64.8\%) developed antral follicle(s) and attempted IVF, and 87 (27.8\%) had no antral follicles and therefore did not receive additional treatment. Among the 201 women who attempted IVF, 82 (26.4\% of total) developed embryos
25 of these women preferred to cryopreserve embryos for transfer at a later stage, while 57 underwent embryo transfer resulting in 13 pregnancies (22.8\% per transfer, 4\% of total). In total, of the 311 women treated with PRP, 25 (8.0\%) achieved livebirth/sustained implantation (spontaneously or after IVF), while another 25 (8.0\%) cryopreserved embryos. Our findings suggest that in women with POI, intraovarian injection of autologous PRP might be considered as an alternative experimental treatment option.
age 24-40) diagnosed with POI based on ESHRE criteria underwent intraovarian PRP injection. Markers of ovarian reserve, and IVF outcome parameters were followed. PRP treatment resulted in increased antral follicle count (AFC) and serum antimullerian hormone (AMH), while serum follicle stimulating hormone (FSH) did not change significantly. After PRP injection, 23 women (7.4\%) conceived spontaneously, 201 (64.8\%) developed antral follicle(s) and attempted IVF, and 87 (27.8\%) had no antral follicles and therefore did not receive additional treatment. Among the 201 women who attempted IVF, 82 (26.4\% of total) developed embryos
25 of these women preferred to cryopreserve embryos for transfer at a later stage, while 57 underwent embryo transfer resulting in 13 pregnancies (22.8\% per transfer, 4\% of total). In total, of the 311 women treated with PRP, 25 (8.0\%) achieved livebirth/sustained implantation (spontaneously or after IVF), while another 25 (8.0\%) cryopreserved embryos. Our findings suggest that in women with POI, intraovarian injection of autologous PRP might be considered as an alternative experimental treatment option.