Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia
dc.contributor.author | Slotman, Berend J. | |
dc.contributor.author | Clark, Mary Ann | |
dc.contributor.author | Ozyar, Enis | |
dc.contributor.author | Kim, Myungsoo | |
dc.contributor.author | Itami, Jun | |
dc.contributor.author | Tallet, Agnes | |
dc.contributor.author | Debus, Juergen | |
dc.contributor.author | Pfeffer, Raphael | |
dc.contributor.author | Gentile, PierCarlo | |
dc.contributor.author | Hama, Yukihiro | |
dc.contributor.author | Andratschke, Nicolaus | |
dc.contributor.author | Riou, Olivier | |
dc.contributor.author | Camilleri, Philip | |
dc.contributor.author | Belka, Claus | |
dc.contributor.author | Quivrin, Magali | |
dc.contributor.author | Kim, BoKyong | |
dc.contributor.author | Pedersen, Anders | |
dc.contributor.author | Felter, Mette van Overeem | |
dc.contributor.author | Kim, Young Il | |
dc.contributor.author | Kim, Jin Ho | |
dc.contributor.author | Fuss, Martin | |
dc.contributor.author | Valentini, Vincenzo | |
dc.date.accessioned | 2023-02-21T12:42:15Z | |
dc.date.available | 2023-02-21T12:42:15Z | |
dc.date.issued | 2022-01-01 | |
dc.description.abstract | Background Magnetic resonance-guided radiotherapy (MRgRT) utilization is rapidly expanding, driven by advanced capabilities including better soft tissue imaging, continuous intrafraction target visualization, automatic triggered beam delivery, and the availability of on-table adaptive replanning. Our objective was to describe patterns of 0.35 Tesla (T)-MRgRT utilization in Europe and Asia among early adopters of this novel technology. Methods Anonymized administrative data from all 0.35T-MRgRT treatment systems in Europe and Asia were extracted for patients who completed treatment from 2015 to 2020. Detailed treatment information was analyzed for all MR-linear accelerators (linac) and -cobalt systems. Results From 2015 through the end of 2020, there were 5796 completed treatment courses delivered in 46,389 individual fractions. 23.5\% of fractions were adapted. Ultra-hypofractionated (UHfx) dose schedules (1-5 fractions) were delivered for 63.5\% of courses, with 57.8\% of UHfx fractions adapted on-table. The most commonly treated tumor types were prostate (23.5\%), liver (14.5\%), lung (12.3\%), pancreas (11.2\%), and breast (8.0\%), with increasing compound annual growth rates (CAGRs) in numbers of courses from 2015 through 2020 (pancreas: 157.1\% | |
dc.description.abstract | prostate: 120.9\% | |
dc.description.abstract | lung: 136.0\% | |
dc.description.abstract | liver: 134.2\%). Conclusions This is the first comprehensive study reporting patterns of utilization among early adopters of a 0.35T-MRgRT system in Europe and Asia. Intrafraction MR image-guidance, advanced motion management, and increasing adoption of on-table adaptive RT have accelerated a transition to UHfx regimens. MRgRT has been predominantly used to treat tumors in the upper abdomen, pelvis and lungs, and increasingly with adaptive replanning, which is a radical departure from legacy radiotherapy practices. | |
dc.description.issue | 1 | |
dc.description.issue | AUG 22 | |
dc.description.volume | 17 | |
dc.identifier.doi | 10.1186/s13014-022-02114-2 | |
dc.identifier.uri | https://hdl.handle.net/11443/2799 | |
dc.identifier.uri | http://dx.doi.org/10.1186/s13014-022-02114-2 | |
dc.identifier.wos | WOS:000843128200002 | |
dc.publisher | BMC | |
dc.relation.ispartof | RADIATION ONCOLOGY | |
dc.subject | MRI-guided radiotherapy | |
dc.subject | MR-IGRT | |
dc.subject | Stereotactic body radiotherapy | |
dc.subject | SBRT | |
dc.subject | Stereotactic ablative radiation therapy | |
dc.subject | SABR | |
dc.subject | ART | |
dc.subject | oART | |
dc.subject | On-table adaptive radiation therapy | |
dc.subject | Care patterns | |
dc.title | Clinical adoption patterns of 0.35 Tesla MR-guided radiation therapy in Europe and Asia | |
dc.type | Article |
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