The role of red cell distribution width in the locoregional recurrence of laryngeal cancer
The role of red cell distribution width in the locoregional recurrence of laryngeal cancer
thumbnail.default.placeholder
Tarih
2019-01-01
Yazarlar
Bozkurt, Gulpembe
Korkut, Arzu Yasemin
Soytas, Pinar
Dizdar, Senem Kurt
Erol, Zeynep Nur
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
ASSOC BRASILEIRA OTORRINOLARINGOLOGIA \& CIRURGIA CERVICOFACIAL
Dergi Adı
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
Özet
Introduction: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. Objective: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. Methods: All laryngeal cancer patients who underwent curative surgery (n= 132) over a 7 year study period were evaluated. Data on demographics, primary tumor site, T-stage, N-stage, histological features (differentiation
the presence of perineural/perivascular invasion), treatment group (total laryngectomy or partial laryngectomy) or adjuvant therapy (chemotherapy/radiotherapy)
laboratory parameters (complete blood count, including the pre-operative red cell distribution width), and disease-free survival rates were retrospectively reviewed. All cases were divided into three groups by the red cell distribution width tertile {[}<13\% (25th percentile) (n=31), 13-14.4\% (50th percentile) (n=72), and >14.4\% (75th percentile) (n=29)]. Results: High-red cell distribution width group included more patients of advanced age, and more of those with recurrent and metastatic tumors (p= 0.005, 0.048, and 0.043, respectively). Individuals with red cell distribution width >14.4\% (75th percentile) had lower disease free survival rates than did those with red cell distribution width <13\% (25th percentile) (p = 0.014). Patients with red cell distribution width >14.4\% at diagnosis were at a higher risk of locoregional recurrence (hazard ratio =5.818, 95\% confidence interval (95\% CI) 1.25-26.97
p= 0.024) than patients with a normal red cell distribution width (<13\%). Conclusion: We found that the pretreatment red cell distribution width was independently prognostic of disease free survival rate in patients with laryngeal cancer and may serve as a new, accurate, and reproducible means of identifying early-stage laryngeal cancer patients with poorer prognoses. (C) 2018 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
the presence of perineural/perivascular invasion), treatment group (total laryngectomy or partial laryngectomy) or adjuvant therapy (chemotherapy/radiotherapy)
laboratory parameters (complete blood count, including the pre-operative red cell distribution width), and disease-free survival rates were retrospectively reviewed. All cases were divided into three groups by the red cell distribution width tertile {[}<13\% (25th percentile) (n=31), 13-14.4\% (50th percentile) (n=72), and >14.4\% (75th percentile) (n=29)]. Results: High-red cell distribution width group included more patients of advanced age, and more of those with recurrent and metastatic tumors (p= 0.005, 0.048, and 0.043, respectively). Individuals with red cell distribution width >14.4\% (75th percentile) had lower disease free survival rates than did those with red cell distribution width <13\% (25th percentile) (p = 0.014). Patients with red cell distribution width >14.4\% at diagnosis were at a higher risk of locoregional recurrence (hazard ratio =5.818, 95\% confidence interval (95\% CI) 1.25-26.97
p= 0.024) than patients with a normal red cell distribution width (<13\%). Conclusion: We found that the pretreatment red cell distribution width was independently prognostic of disease free survival rate in patients with laryngeal cancer and may serve as a new, accurate, and reproducible means of identifying early-stage laryngeal cancer patients with poorer prognoses. (C) 2018 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.
Açıklama
Anahtar kelimeler
Red cell distribution width, Larynx cancer, Disease free survival