Comparison of TRUS and combined MRI-targeted plus systematic prostate biopsy for the concordance between biopsy and radical prostatectomy pathology
dc.contributor.author | Aslan, Guven | |
dc.contributor.author | Celik, Serdar | |
dc.contributor.author | Sozen, Sinan | |
dc.contributor.author | Akdogan, Bulent | |
dc.contributor.author | Izol, Volkan | |
dc.contributor.author | Bilen, Cenk Yucel | |
dc.contributor.author | Sahin, Bahadir | |
dc.contributor.author | Turkeri, Levent | |
dc.contributor.author | Assoc, Urooncology | |
dc.date.accessioned | 2023-02-21T12:39:42Z | |
dc.date.available | 2023-02-21T12:39:42Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | Aim: To evaluate the accuracy in histologic grading of MRI/US image fusion biopsy by comparing conventional 12-core TRUS-Bx at radical prostatectomy specimens (RP). Methods: Consecutive patients diagnosed prostate cancer (127 with combination of both targeted biopsy (TBx) plus systematic biopsies (SBx) and separate patient cohort of 330 conventional TRUS-Bx without mpMRI) with a PSA level of <20 ng/mL prior to RP were included. The primary end point was the grade group concordance between biopsy and RP pathology according to biopsy technique. Results: Clinically significant prostate cancer detection was 51.2\% for TRUS-Bx, 49.5\% for SBx, 67\% for TBx and 75.7\% for TBx + SBx. Upgrading and downgrading of at least one Gleason Grade Group (GGG) was recorded in 43.3\%/ 6.7\% patients of the TRUS-Bx and in 20.5\%/ 22\% of the TBX + SBx group, respectively (all P <.001). Concordance level was detected to be significantly higher for ISUP 1 in combined TBx + SBx method compared to conventional TRUS-Bx (61.3\% vs 37.9\%, P =.014). In ISUP 1 exclusively, significant upgrading was seen in TRUS-Bx (62.1\%) when compared to TBx (41.4\%) and TBx + SBx (38.7\%). Conclusions: MRI-targeted biopsies detected more significant PCa than TRUS-Bx but, superiority in significant cancer detection appears as a result of inadvertant selective sampling of small higher grade areas. Within an otherwise low grade cancer and does not reflect accurate GGG final surgical pathology. TBx + SBx has the greatest concordance in ISUP Grade 1 with less upgrading which is utmost important for active surveillance. | |
dc.description.issue | 3 | |
dc.description.issue | MAR | |
dc.description.volume | 75 | |
dc.identifier.doi | 10.1111/ijcp.13797 | |
dc.identifier.uri | https://hdl.handle.net/11443/2535 | |
dc.identifier.uri | http://dx.doi.org/10.1111/ijcp.13797 | |
dc.identifier.wos | WOS:000591447500001 | |
dc.publisher | WILEY | |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | |
dc.title | Comparison of TRUS and combined MRI-targeted plus systematic prostate biopsy for the concordance between biopsy and radical prostatectomy pathology | |
dc.type | Article |
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