Potential role of Muller cells in the pathogenesis of macropsia associated with epiretinal membrane: a hypothesis revisited
Potential role of Muller cells in the pathogenesis of macropsia associated with epiretinal membrane: a hypothesis revisited
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Tarih
2017-01-01
Yazarlar
Colakoglu, Ahmet
Akar, Solmaz Balci
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
IJO PRESS
Dergi Adı
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
Özet
Pathophysiological explanations for metamorphopsia associated with retinal pathologies generally focus on photoreceptor organization disruption. However, the retinal microarchitecture is complicated, and we hypothesize that other retinal cells may also be involved. Metamorphopsia has been widely studied in eyes with epiretinal membranes and we revisit the idea that Muller cell displacement causes retinal macropsia. A PubMed query and related article search for the macula ultrastructure under normal and pathological conditions revealed an enormous amount of information, particularly ultrahigh definition optical coherence tomography and other retinal imaging modality studies. Findings of these imaging studies support our hypothesis that Muller cells, and not cone photoreceptors, are primarily responsible for macropsia in eyes with epiretinal membranes. More specifically, we conclude that displacement of Muller cell endfeet, and not photoreceptor cones, is a more likely the explanation for retinal macropsia associated with epiretinal membranes.
Açıklama
Anahtar kelimeler
macropsia, metamorphopsia, epiretinal membrane, Muller cells