The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress, and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease

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dc.contributor.authorBingul, Ilknur
dc.contributor.authorAydin, A. Fatih
dc.contributor.authorKucukgergin, Canan
dc.contributor.authorDogan-Ekici, Isin
dc.contributor.authorDogru-Abbasoglu, Semra
dc.contributor.authorUysal, Mujdat
dc.date.accessioned2023-02-21T12:33:42Z
dc.date.available2023-02-21T12:33:42Z
dc.date.issued2021-01-01
dc.description.abstractBackground/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)(2)D-3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)(2)D-3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30\%) or ethanol (5-20\%) in drinking water with and without 1,25(OH)(2)D-3 treatment (5 mu g/kg two times a week) for 8 weeks. Insulin resistance (IR), oxidative stress parameters, AGEs, triglyceride (TG), and hydroxyproline (Hyp) levels together with histopathology were investigated in the liver. Results: 1,25(OH)(2)D-3 decreased hepatic reactive oxygen species, lipid and protein oxidation products together with histopathological improvements in HFr- and EtOH-treated rats. 1,25(OH)(2)D-3 treatment was observed to decrease significantly serum and hepatic AGEs in HFr group, and hepatic AGEs in EtOH group. Conclusion: Our results clearly show that 1,25(OH)(2)D-3 treatment may be useful in the alleviation of hepatic lesions by decreasing glycooxidant stress in both NAFLD and ALD models created by HFr- and EtOH-treated rats, respectively.
dc.description.issue3
dc.description.pages1500-1511
dc.description.volume51
dc.identifier.doi10.3906/sag-2007-289
dc.identifier.urihttps://hdl.handle.net/11443/1563
dc.identifier.urihttp://dx.doi.org/10.3906/sag-2007-289
dc.identifier.wosWOS:000668257500012
dc.publisherSCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.subjectVitamin D
dc.subjectfructose
dc.subjectethanol
dc.subjectoxidative stress
dc.subjectglycation end products
dc.titleThe effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress, and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease
dc.typeArticle
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