The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses
The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses
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Tarih
2016-01-01
Yazarlar
Topdag, Murat
Kara, Ahmet
Konuk, Esma
Demir, Necdet
Ozturk, Murat
Caliskan, Sebla
Topdag, Deniz Ozlem
Ulubil, Arif
Keskin, Ibrahim Gurkan
Iseri, Mete
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
KOREAN SOC OTORHINOLARYNGOL
Dergi Adı
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
Özet
Objectives. Healing processes of the nose and paranasal sinuses are quite complex, and poorly understood. In this study, we aimed to compare the effect of mucosal autologous grafts on the degenerated rabbit maxillary sinus mucosa with spontaneous wound healing. It is hypothesized that mucosal grafts will enhance ciliogenesis and improve the morphology of regenerated cilia. Methods. Ten female New Zealand rabbits were included in the study. They underwent external maxillary sinus surgery through a transcutaneous approach. A total of 20 maxillary sinuses were randomly divided into 2 groups: `spontaneous healing group' and `autologous graft group.' The animals were sacrificed at the 14th day after the surgery. Scanning electron microscope (SEM), and light microscope were used for the evaluation. Results. Cellular composition of the graft group is better than the spontaneous healing group. The graft group had larger areas covered with ciliary epithelium than the spontaneous healing group, and the mean length of the cilias were also longer. Additionally, there were wider cilia with abnormal morphology areas in the spontaneous healing group. Conclusion. In our opinion, covering of the denuded areas with a graft improves re-epithelization, and may prevent the early complications after sinus surgeries.
Açıklama
Anahtar kelimeler
Nasal Mucosa, Maxillary Sinus, Rabbits