The Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses

dc.contributor.authorTopdag, Murat
dc.contributor.authorKara, Ahmet
dc.contributor.authorKonuk, Esma
dc.contributor.authorDemir, Necdet
dc.contributor.authorOzturk, Murat
dc.contributor.authorCaliskan, Sebla
dc.contributor.authorTopdag, Deniz Ozlem
dc.contributor.authorUlubil, Arif
dc.contributor.authorKeskin, Ibrahim Gurkan
dc.contributor.authorIseri, Mete
dc.date.accessioned2023-02-21T12:34:51Z
dc.date.available2023-02-21T12:34:51Z
dc.date.issued2016-01-01
dc.description.abstractObjectives. Healing processes of the nose and paranasal sinuses are quite complex, and poorly understood. In this study, we aimed to compare the effect of mucosal autologous grafts on the degenerated rabbit maxillary sinus mucosa with spontaneous wound healing. It is hypothesized that mucosal grafts will enhance ciliogenesis and improve the morphology of regenerated cilia. Methods. Ten female New Zealand rabbits were included in the study. They underwent external maxillary sinus surgery through a transcutaneous approach. A total of 20 maxillary sinuses were randomly divided into 2 groups: `spontaneous healing group' and `autologous graft group.' The animals were sacrificed at the 14th day after the surgery. Scanning electron microscope (SEM), and light microscope were used for the evaluation. Results. Cellular composition of the graft group is better than the spontaneous healing group. The graft group had larger areas covered with ciliary epithelium than the spontaneous healing group, and the mean length of the cilias were also longer. Additionally, there were wider cilia with abnormal morphology areas in the spontaneous healing group. Conclusion. In our opinion, covering of the denuded areas with a graft improves re-epithelization, and may prevent the early complications after sinus surgeries.
dc.description.issue1
dc.description.issueMAR
dc.description.pages44-50
dc.description.volume9
dc.identifier.doi10.21053/ceo.2016.9.1.44
dc.identifier.urihttps://hdl.handle.net/11443/1825
dc.identifier.urihttp://dx.doi.org/10.21053/ceo.2016.9.1.44
dc.identifier.wosWOS:000372773000008
dc.publisherKOREAN SOC OTORHINOLARYNGOL
dc.relation.ispartofCLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
dc.subjectNasal Mucosa
dc.subjectMaxillary Sinus
dc.subjectRabbits
dc.titleThe Healing Effects of Autologous Mucosal Grafts in Experimentally Injured Rabbit Maxillary Sinuses
dc.typeArticle
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