Ovarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)

dc.contributor.authorCakiroglu, Yigit
dc.contributor.authorYuceturk, Aysen
dc.contributor.authorKaraosmanoglu, Ozge
dc.contributor.authorKopuk, Sule Yildirim
dc.contributor.authorKorun, Zeynep Ece Utkan
dc.contributor.authorHerlihy, Nola
dc.contributor.authorScott, Richard T.
dc.contributor.authorTiras, Bulent
dc.contributor.authorSeli, Emre
dc.date.accessioned2023-02-21T12:37:40Z
dc.date.available2023-02-21T12:37:40Z
dc.date.issued2022-01-01
dc.description.abstractThe aim of the current study was to characterize ovarian reserve parameters and IVF outcomes in women with a history of poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP). Reproductive age women (N=510
dc.description.abstractage range 30-45yo) diagnosed with POR based on Poseidon criteria were included in the study. PRP treatment resulted in higher AFC, higher serum AMH, lower serum FSH, and a higher number of mature oocytes and cleavage and blastocyst stage embryos. After PRP injection, 22 women (4.3\%) conceived spontaneously, 14 (2.7\%) were lost to follow up, and 474 (92.9\%) attempted IVF. Among women who attempted IVF, 312 (65.8\%) generated embryos and underwent embryo transfer, 83 (17.5\%) achieved a pregnancy, and 54 (11.4\%) achieved sustained implantation/live birth (SI/LB). In total, of the 510 women with POR and mean age of 40.3, PRP resulted in improvement of ovarian reserve parameters, a pregnancy rate of 20.5\% and SI/LB rate of 12.9\%. Our findings suggest that PRP treatment may be considered in women with POR. For wider clinical application, its clinical efficacy will need to be demonstrated in prospective randomized clinical trials.
dc.description.issue6
dc.description.issueMAR 31
dc.description.pages2513-2523
dc.description.volume14
dc.identifier.urihttps://hdl.handle.net/11443/2277
dc.identifier.wosWOS:000782645200008
dc.publisherIMPACT JOURNALS LLC
dc.relation.ispartofAGING-US
dc.subjectpoor ovarian response
dc.subjectplatelet rich plasma
dc.subjectin vitro fertilization
dc.titleOvarian reserve parameters and IVF outcomes in 510 women with poor ovarian response (POR) treated with intraovarian injection of autologous platelet rich plasma (PRP)
dc.typeArticle

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