Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy

Repetowski, Pawel; Warszynska, Marta; Dumoulin, Fabienne; Dabrowski, Janusz M.

doi:10.1039/d6na00602g

Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy

Date

2026

Authors

dc.identifier.issn

2516-0230

dc.identifier.doi

10.1039/d6na00602g

dc.description.volume

8

dc.description.issue

18

Publisher

ROYAL SOC CHEMISTRY

DOI

10.1039/d6na00602g
10.1039/d6na00602g

Abstract

Pluronic (R) P123 micelles stabilized a sulfonyl-substituted zinc(ii) phthalocyanine, prolonged its triplet-state lifetime, and preserved ROS photochemistry under biologically relevant conditions. Pharmacokinetic-guided C-PDT at a 24 h DLI remained insufficient as monotherapy, whereas combination with PD-L1 blockade produced durable tumor control. Rechallenge experiments after PDT additionally revealed complete long-term antitumor immune memory.

Keywords

IMMUNOGENIC CELL-DEATH , CANCER , THERAPY , OXYGEN , Chemistry, Multidisciplinary , Nanoscience & Nanotechnology , Materials Science, Multidisciplinary , Chemistry , Science & Technology - Other Topics , Materials Science

URI

https://doi.org/10.1039/d6na00602g
https://openaccess.acibadem.edu.tr/handle/11443/10475

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Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy

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