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Sulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy

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dc.contributor.authorRepetowski, Pawel
dc.contributor.authorWarszynska, Marta
dc.contributor.authorDumoulin, Fabienne
dc.contributor.authorDabrowski, Janusz M.
dc.date.accessioned2026-11-05T11:00:33Z
dc.date.issued2026
dc.description.abstractPluronic (R) P123 micelles stabilized a sulfonyl-substituted zinc(ii) phthalocyanine, prolonged its triplet-state lifetime, and preserved ROS photochemistry under biologically relevant conditions. Pharmacokinetic-guided C-PDT at a 24 h DLI remained insufficient as monotherapy, whereas combination with PD-L1 blockade produced durable tumor control. Rechallenge experiments after PDT additionally revealed complete long-term antitumor immune memory.
dc.description.issue18
dc.description.pages5102-5107
dc.description.sponsorshipThis research was funded by the National Science Center (NCN) within the framework of project no. 2020/37/B/NZ7/04157 awarded to JMD. Studies on triplet-state lifetimes and ROS detection in micellar formulations were additionally funded by the National Science Center (NCN) under project no. 2024/55/B/NZ7/03169, also awarded to JMD. The authors gratefully acknowledge Dr Micha & lstrok; Pacia for assistance with transmission electron microscopy (TEM) imaging, Dr Joanna Kuncewicz for support with transient absorption spectroscopy (TAS), Dr & Lstrok;ukasz Orze & lstrok; for fluorescence lifetime measurements and Ewa Werner, MSc, Eng. for her invaluable assistance with the in vivo experiments.
dc.description.volume8
dc.identifier.doi10.1039/d6na00602g
dc.identifier.issn2516-0230
dc.identifier.urihttps://doi.org/10.1039/d6na00602g
dc.identifier.urihttps://openaccess.acibadem.edu.tr/handle/11443/10475
dc.identifier.wosWOS:001851522900001
dc.language.isoen
dc.publisherROYAL SOC CHEMISTRY
dc.relation.fundingNarodowe Centrum Nauki
dc.relation.fundingNarodowe Centrum Nauki [2024/55/B/NZ7/03169, 2020/37/B/NZ7/04157]
dc.relation.hasversion10.1039/d6na00602g
dc.relation.ispartofNANOSCALE ADVANCES
dc.subjectIMMUNOGENIC CELL-DEATH
dc.subjectCANCER
dc.subjectTHERAPY
dc.subjectOXYGEN
dc.subjectChemistry, Multidisciplinary
dc.subjectNanoscience & Nanotechnology
dc.subjectMaterials Science, Multidisciplinary
dc.subjectChemistry
dc.subjectScience & Technology - Other Topics
dc.subjectMaterials Science
dc.titleSulfonyl-substituted zinc phthalocyanine micelles with long-lived triplet states enable durable photodynamic immunotherapy
dc.typeArticle
oaire.citation.editionScience Citation Index Expanded (SCI-EXPANDED)
oaire.citation.endPage5107
oaire.citation.issue18
oaire.citation.startPage5102
oaire.citation.volume8
person.identifier.ridGSO-3192-2022
person.identifier.ridAAA-9838-2019
person.identifier.ridE-7250-2015

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