p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis

dc.contributor.authorKolgazi, Meltem
dc.contributor.authorOztosun, Gulsen
dc.contributor.authorYalcin, Muge
dc.contributor.authorUnan, Zehra Neslisah
dc.contributor.authorArsoy, Edanur
dc.contributor.authorOral, Simge
dc.contributor.authorCilingir, Sumeyye
dc.contributor.authorAcikel Elmas, Merve
dc.contributor.authorArbak, Serap
dc.date.accessioned2023-02-21T12:33:27Z
dc.date.available2023-02-21T12:33:27Z
dc.date.issued2021-01-01
dc.description.abstractObjective: p-Coumaric acid is commonly found in edible plants in nature and is known to be an effective antioxidant. This study aimed to investigate the therapeutic effects of p-coumaric acid on ethanol-induced gastric ulcer model Materials and Methods: After an 18-hour starvation period, the ulcer was induced in male Sprague-Dawley (250-300) rats by intragastric administration of 75\% ethanol. An hour after ulcer induction, p-coumaric acid (250 mg/kg) suspended in 1 ml tween-80 was administered intragastrically. The control and ulcer groups received 1 ml tween-80, One hour later, all rats were euthanized and stomach samples were collected for macroscopic examination, histological evaluation, and measurement of myeloperoxidase (MPO) activity, malondialdehyde (MDA), and glutathione (GSH) levels. Results: Ethanol induction resulted in gastric epithelial and mucosa' injury, increased MPO activity and MDA levels
dc.description.abstractand decreased GSH levels. Treatment with p-coumaric acid at a dose of 250 mg/kg markedly improved the gastric injury macroscopically, microscopically, and biochemically due to decreasing MPO activity and MDA levels while increasing GSH levels. Conclusion: p-Couniaric acid markedly ameliorated the gastric epithelial and mucosal injury induced by ethanol. The therapeutic effects of p-coumaric acid could be due to its antioxidant properties and protective role against GSH depletion and neutrophil accumulation.
dc.description.issue1
dc.description.pages6-11
dc.description.volume34
dc.identifier.doi10.5472/marumj.859006
dc.identifier.urihttps://hdl.handle.net/11443/1495
dc.identifier.urihttp://dx.doi.org/10.5472/marumj.859006
dc.identifier.wosWOS:000614328300002
dc.publisherMARMARA UNIV, FAC MEDICINE
dc.relation.ispartofMARMARA MEDICAL JOURNAL
dc.subjectp-Coumaric acid
dc.subjectUlcer
dc.subjectEthanol
dc.subjectAntioxidant
dc.subjectNeutrophil
dc.titlep-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
p-Coumaric acid has an ameliorative effect on peptic ulcer a macroscopic, microscopic and biochemical analysis.pdf
Size:
761.59 KB
Format:
Adobe Portable Document Format

Collections