p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis
dc.contributor.author | Kolgazi, Meltem | |
dc.contributor.author | Oztosun, Gulsen | |
dc.contributor.author | Yalcin, Muge | |
dc.contributor.author | Unan, Zehra Neslisah | |
dc.contributor.author | Arsoy, Edanur | |
dc.contributor.author | Oral, Simge | |
dc.contributor.author | Cilingir, Sumeyye | |
dc.contributor.author | Acikel Elmas, Merve | |
dc.contributor.author | Arbak, Serap | |
dc.date.accessioned | 2023-02-21T12:33:27Z | |
dc.date.available | 2023-02-21T12:33:27Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | Objective: p-Coumaric acid is commonly found in edible plants in nature and is known to be an effective antioxidant. This study aimed to investigate the therapeutic effects of p-coumaric acid on ethanol-induced gastric ulcer model Materials and Methods: After an 18-hour starvation period, the ulcer was induced in male Sprague-Dawley (250-300) rats by intragastric administration of 75\% ethanol. An hour after ulcer induction, p-coumaric acid (250 mg/kg) suspended in 1 ml tween-80 was administered intragastrically. The control and ulcer groups received 1 ml tween-80, One hour later, all rats were euthanized and stomach samples were collected for macroscopic examination, histological evaluation, and measurement of myeloperoxidase (MPO) activity, malondialdehyde (MDA), and glutathione (GSH) levels. Results: Ethanol induction resulted in gastric epithelial and mucosa' injury, increased MPO activity and MDA levels | |
dc.description.abstract | and decreased GSH levels. Treatment with p-coumaric acid at a dose of 250 mg/kg markedly improved the gastric injury macroscopically, microscopically, and biochemically due to decreasing MPO activity and MDA levels while increasing GSH levels. Conclusion: p-Couniaric acid markedly ameliorated the gastric epithelial and mucosal injury induced by ethanol. The therapeutic effects of p-coumaric acid could be due to its antioxidant properties and protective role against GSH depletion and neutrophil accumulation. | |
dc.description.issue | 1 | |
dc.description.pages | 6-11 | |
dc.description.volume | 34 | |
dc.identifier.doi | 10.5472/marumj.859006 | |
dc.identifier.uri | https://hdl.handle.net/11443/1495 | |
dc.identifier.uri | http://dx.doi.org/10.5472/marumj.859006 | |
dc.identifier.wos | WOS:000614328300002 | |
dc.publisher | MARMARA UNIV, FAC MEDICINE | |
dc.relation.ispartof | MARMARA MEDICAL JOURNAL | |
dc.subject | p-Coumaric acid | |
dc.subject | Ulcer | |
dc.subject | Ethanol | |
dc.subject | Antioxidant | |
dc.subject | Neutrophil | |
dc.title | p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis | |
dc.type | Article |
Files
Original bundle
1 - 1 of 1
- Name:
- p-Coumaric acid has an ameliorative effect on peptic ulcer a macroscopic, microscopic and biochemical analysis.pdf
- Size:
- 761.59 KB
- Format:
- Adobe Portable Document Format