Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study

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dc.contributor.authorBellikci-Koyu, Ezgi
dc.contributor.authorSarer-Yurekli, Banu Pinar
dc.contributor.authorAkyon, Yakut
dc.contributor.authorAydin-Kose, Fadime
dc.contributor.authorKaragozlu, Cem
dc.contributor.authorOzgen, Ahmet Gokhan
dc.contributor.authorBrinkmann, Annika
dc.contributor.authorNitsche, Andreas
dc.contributor.authorErgunay, Koray
dc.contributor.authorYilmaz, Engin
dc.contributor.authorBuyuktuncer, Zehra
dc.date.accessioned2023-02-21T12:38:32Z
dc.date.available2023-02-21T12:38:32Z
dc.date.issued2019-01-01
dc.description.abstractSeveral health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. In a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-alpha, IFN-gamma, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p <= 0.05, for each). However, no significant difference was obtained between the kefir and unfermented milk groups (p > 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition.
dc.description.issue9
dc.description.issueSEP
dc.description.volume11
dc.identifier.doi10.3390/nu11092089
dc.identifier.urihttps://hdl.handle.net/11443/2395
dc.identifier.urihttp://dx.doi.org/10.3390/nu11092089
dc.identifier.wosWOS:000487964600296
dc.publisherMDPI
dc.relation.ispartofNUTRIENTS
dc.subjectkefir
dc.subjectgut microbiota
dc.subjectmetabolic syndrome
dc.titleEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study
dc.typeArticle
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