Risk Factors of Patients with Prostate Cancer Upgrading for International Society of Urological Pathology Grade Group 1 After Radical Prostatectomy

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dc.contributor.authorOzgur, Abdurrahman
dc.contributor.authorOzgur, Gunal
dc.contributor.authorSahin, Bahadir
dc.contributor.authorFilinte, Deniz
dc.contributor.authorTinay, Ilker
dc.contributor.authorcam, Haydar Kamil
dc.contributor.authorTurkeri, Levent
dc.date.accessioned2023-02-21T12:34:00Z
dc.date.available2023-02-21T12:34:00Z
dc.date.issued2022-01-01
dc.description.abstractObjective: This study aimed to determine the predictive factors for patients whose International Society of Urological Pathology (ISUP) score was upgraded in radical prostatectomy (RP) pathologies with a prostate biopsy pathology of ISUP grade group 1. Materials and Methods: Among patients who underwent RP in our clinic within 10 years, 158 patients with prostate biopsy pathology of ISUP grade group 1 were examined retrospectively. Age, serum prostate-specific antigen (PSA) level, prostate biopsy ISUP grade group, number of cores taken in the prostate biopsy, number of tumor-positive cores, RP pathology ISUP grade group, and pathological stage were evaluated. Results: The mean age (+/- standard) of the 158 patients whose prostate biopsy pathology was ISUP grade group 1 were 64.07 (+/- 6.6). ISUP group upgrading was detected in 47 patients (29.7\%). The mean PSA value of these patients was 10.6 ng/mL (+/- 6.9). The mean PSA value of the other 111 patients without ISUP group upgrading was 7.98 ng/mL (+/- 4.9). The serum PSA level was significantly higher in patients with upgraded ISUP in the RP pathology (p=0.02). The percentage of tumor-positive cores in the group with ISUP group upgrading (37\%) was significantly higher than that in the group without ISUP group upgrading (27\%) (p=0.01). The detection rates of surgical margin positivity (42.6\% vs. 18\%), capsule invasion (55.3\% vs. 19.8\%), and seminal vesicle invasion (23.6\% vs. 3.6\%) were also significantly higher in the upgraded ISUP group after RP (p<0.05). Conclusion: The results of this trial suggest that active surveillance may not be an appropriate option for patients with biopsy ISUP grade group 1 with PSA level >10 ng/mL. Moreover, the presence of a higher number and percentage of tumor-positive cores constituted risks of ISUP group upgrading with concomitant poor pathological outcomes such as surgical margin positivity, capsule invasion, and seminal vesicle invasion.
dc.description.issue1
dc.description.issueMAR
dc.description.pages10-13
dc.description.volume21
dc.identifier.doi10.4274/uob.galenos.2021.2021.8.3
dc.identifier.urihttps://hdl.handle.net/11443/1641
dc.identifier.urihttp://dx.doi.org/10.4274/uob.galenos.2021.2021.8.3
dc.identifier.wosWOS:000752934900002
dc.publisherGALENOS YAYINCILIK
dc.relation.ispartofUROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY
dc.subjectProstate cancer
dc.subjectinternational society of urological pathology score
dc.subjectradical prostatectomy
dc.titleRisk Factors of Patients with Prostate Cancer Upgrading for International Society of Urological Pathology Grade Group 1 After Radical Prostatectomy
dc.typeArticle
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