Evaluation of the Relationships between Obesity and Central Retinal Thickness, Retinal Nerve Fiber Layer, Intraocular Pressure, and Central Corneal Thickness in Children
Evaluation of the Relationships between Obesity and Central Retinal Thickness, Retinal Nerve Fiber Layer, Intraocular Pressure, and Central Corneal Thickness in Children
Tarih
2022-01-01
Yazarlar
Olcaysü, Osman Okan
Karasu, Buğra
Olcaysü, Elif
Çayır, Atilla
Çelebi, Ali Rıza Cenk
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
Acıbadem Mehmet Ali Aydınlar Üniversitesi
Dergi Adı
Özet
ABSTRACT
Purpose: The purpose of this study was to investigate the effect of childhood obesity on the retinal nerve fiber layer (RNFL), retinal
thickness, central corneal thickness and intraocular pressure.
Method: Children with obesity (n:24) (Group 1; n:48 eyes) and healthy children (n:23) (Group 2; n:46 eyes) were included in the study.
Average RNFL thickness, central 1 mm diameter of foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) were measured using
the fourier domain - optical coherence tomography (FD-OCT). Central corneal thickness (CCT) was measured using contact ultrasonic
pachymetry and intraocular pressure (IOP) using Goldmann applanation tonometry.
Results: The mean IOP in Group 1 was found to be significantly higher (p=0.002) and 16.1 ± 3.1 mmHg in group 1 and 13.6 ± 3.2
mmHg in group 2, respectively. Mean RNFL, CFT and SFCT significantly were lower in group 1 (p < 0.05) than group 2. The average
RNFL was detected to 107.9 ± 10.5 µm in group 1 and 112.6±11.8 µm in group 2, respectively (p=0.001). Mean CFT was found to be
231.6±14.4 µm in group 1 and 245.9±19.98 µm in group 2, respectively (p=0.001). The average SFCT was observed to 193.3±15.3 µm in
group 1 and 221 ± 25.1 µm in group 2, respectively (p<0.001). Although CCT was relatively higher in group 1, no statistically significant
difference was observed among the groups (p=0.08). There was a positive correlation between the presence of obesity and mean IOP
measurements (r = 0.847, p = 0.011), and besides a negative correlation was detected between mean RNFL thickness and mean weight
of the patients (r = -0.749, p = 0.039).
Conclusion: In current study, it should be kept in mind that elevated IOP and decrement of RNFL thickness in children with obesity
increased the risk of developing glaucoma, as well as decreased CFT and SFCT may form the basis for the development of macular diseases
in future.