The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris
dc.contributor.author | Pektas, Suzan Demir | |
dc.contributor.author | Cinar, Nese | |
dc.contributor.author | Duman, Deniz Demircioglu | |
dc.contributor.author | Kara, Ahmet | |
dc.contributor.author | Batu, Janserey | |
dc.contributor.author | Karakas-Celik, Sevim | |
dc.contributor.author | Aksoy, Duygu Yazgan | |
dc.date.accessioned | 2023-02-21T12:35:49Z | |
dc.date.available | 2023-02-21T12:35:49Z | |
dc.date.issued | 2020-01-01 | |
dc.description.abstract | Introduction: Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited. Aim: To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris. Material and methods: Thirty-five post-adolescent male patients with a mean age of 28.0 +/- 5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, insulin sensitivity parameters and ghrelin levels were determined. The PCR method was used for GHRL polymorphisms (rs27647, rs696217 and rs34911341 genotypes). Results: Patients had similar anthropometric measures to controls, except a significantly higher WHR in patients (0.92 +/- 0.06 vs. 0.86 +/- 0.08, p < 0.05). Also, FPG, HOMA-IR values, lipid profile and serum androgen levels were similar. Interestingly, patients had significantly lower ghrelin levels than controls (4.5 +/- 5.8 vs. 101.2 +/- 86.5 pg/ml, p < 0.001). The frequencies of rs696217 and rs34911341 genotypes were similar whereas the distribution of rs27647 alleles was significantly different between the groups (p < 0.05). GA and GG genotypes of GHRL rs27647 polymorphism indicated an increased risk of developing acne vulgaris (OR = 11.156, 95\% CI: 2.864-43.464, OR = 5.312, 95\% CI: 1.269-22.244, respectively | |
dc.description.abstract | p < 0.05). Patients with rs27647-AA polymorphism had significantly lower GAGS scores than other groups (AA genotype 6.7 +/- 14.1 vs. GA genotype 24.6 +/- 15.7 and GG genotype 19.4 +/- 17.9, p < 0.001). None of the polymorphisms had a significant effect on metabolic parameters, insulin sensitivity and serum ghrelin levels. Conclusions: Decreased ghrelin levels and GA and GG genotypes of GHRL gene rs27647 polymorphism may have a role in the pathogenesis of acne vulgaris. | |
dc.description.issue | 5 | |
dc.description.pages | 800-809 | |
dc.description.volume | 37 | |
dc.identifier.doi | 10.5114/ada.2020.100492 | |
dc.identifier.uri | https://hdl.handle.net/11443/2001 | |
dc.identifier.uri | http://dx.doi.org/10.5114/ada.2020.100492 | |
dc.identifier.wos | WOS:000615600500027 | |
dc.publisher | TERMEDIA PUBLISHING HOUSE LTD | |
dc.relation.ispartof | POSTEPY DERMATOLOGII I ALERGOLOGII | |
dc.subject | acne vulgaris | |
dc.subject | insulin resistance | |
dc.subject | ghrelin | |
dc.subject | ghrelin polymorphisms | |
dc.subject | post-adolescent | |
dc.title | The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris | |
dc.type | Article |