Effects of Parenteral Nutritional Support with Fish-Oil Emulsion on Spinal Cord Recovery in Rats with Traumatic Spinal Cord Injury

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dc.contributor.authorEmon, Selin Tural
dc.contributor.authorIrban, Arzu Gercek
dc.contributor.authorBozkurt, Suheyla Uyar
dc.contributor.authorAkakin, Dilek
dc.contributor.authorKonya, Deniz
dc.contributor.authorOzgen, Serdar
dc.date.accessioned2023-02-21T12:35:03Z
dc.date.available2023-02-21T12:35:03Z
dc.date.issued2011-01-01
dc.description.abstractAIM: Aim of this study is to assess effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury. MATERIAL and METHODS: For 5 days after SCI rats were received saline in group C and Omegaven in group O. Locomotor strengths (BBB scale)of animals were rated at Day 0,7,14,21,28, and 35. At Day 35 spinal cord sampling was evaluated immunohistochemically. RESULTS: BBB scores were 0 in early period after SCI was inflicted in both groups. BBB scores were progressively increased after Day 7 in both groups (p <.005). BBB scores were significantly higher in group O when compared with control group after Day7 in all times (p <.005). Neuronal injury (p <.002) and edema was much more in control group when compared with in group O (p <.005). Scores for white mater cavitation, demyelinization and vessel in growth were similar in both groups. VEGF expression in control group was higher (p=.019). CONCLUSION: At the early period of SCI fish-oil emulsion treatment in rats, its anti-inflammatory effects leaded to decrease in edema and had positive effect at the prevention of neuronal injury. We believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.
dc.description.issue2
dc.description.issueAPR
dc.description.pages197-202
dc.description.volume21
dc.identifier.urihttps://hdl.handle.net/11443/1860
dc.identifier.wosWOS:000290371700013
dc.publisherTURKISH NEUROSURGICAL SOC
dc.relation.ispartofTURKISH NEUROSURGERY
dc.subjectOmega-3 fatty acids
dc.subjectOmega-6 fatty acids
dc.subjectNeuron recovery
dc.subjectNutrition
dc.subjectSpinal cord injury
dc.titleEffects of Parenteral Nutritional Support with Fish-Oil Emulsion on Spinal Cord Recovery in Rats with Traumatic Spinal Cord Injury
dc.typeArticle
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