Association of B7-H4 gene polymorphisms in urothelial bladder cancer
dc.contributor.author | Ozgoz, Asuman | |
dc.contributor.author | Samli, Murat | |
dc.contributor.author | Dincel, Deniz | |
dc.contributor.author | Sahin, Ahmet | |
dc.contributor.author | Ince, Umit | |
dc.contributor.author | Saglican, Yesim | |
dc.contributor.author | Balci, Faruk | |
dc.contributor.author | Samli, Hale | |
dc.date.accessioned | 2023-02-21T12:35:22Z | |
dc.date.available | 2023-02-21T12:35:22Z | |
dc.date.issued | 2017-01-01 | |
dc.description.abstract | Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma. | |
dc.description.issue | 2 | |
dc.description.pages | 443-446 | |
dc.description.volume | 47 | |
dc.identifier.doi | 10.3906/sag-1603-54 | |
dc.identifier.uri | https://hdl.handle.net/11443/1917 | |
dc.identifier.uri | http://dx.doi.org/10.3906/sag-1603-54 | |
dc.identifier.wos | WOS:000399829700012 | |
dc.publisher | TUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY | |
dc.relation.ispartof | TURKISH JOURNAL OF MEDICAL SCIENCES | |
dc.subject | Bladder cancer | |
dc.subject | polymorphism | |
dc.subject | B7-H4 gene | |
dc.title | Association of B7-H4 gene polymorphisms in urothelial bladder cancer | |
dc.type | Article |