Association of B7-H4 gene polymorphisms in urothelial bladder cancer

dc.contributor.authorOzgoz, Asuman
dc.contributor.authorSamli, Murat
dc.contributor.authorDincel, Deniz
dc.contributor.authorSahin, Ahmet
dc.contributor.authorInce, Umit
dc.contributor.authorSaglican, Yesim
dc.contributor.authorBalci, Faruk
dc.contributor.authorSamli, Hale
dc.date.accessioned2023-02-21T12:35:22Z
dc.date.available2023-02-21T12:35:22Z
dc.date.issued2017-01-01
dc.description.abstractBackground/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
dc.description.issue2
dc.description.pages443-446
dc.description.volume47
dc.identifier.doi10.3906/sag-1603-54
dc.identifier.urihttps://hdl.handle.net/11443/1917
dc.identifier.urihttp://dx.doi.org/10.3906/sag-1603-54
dc.identifier.wosWOS:000399829700012
dc.publisherTUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY
dc.relation.ispartofTURKISH JOURNAL OF MEDICAL SCIENCES
dc.subjectBladder cancer
dc.subjectpolymorphism
dc.subjectB7-H4 gene
dc.titleAssociation of B7-H4 gene polymorphisms in urothelial bladder cancer
dc.typeArticle

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